Display options
Cite
Musavi Z, Azarpira N, Sangtarash MH, et al. Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation. Int J Organ Transplant Med. 2015;6(1):14-22
Musavi, Z., Azarpira, N., Sangtarash, M. H., Kordi, M., Kazemi, K., Geramizadeh, B., & Malek-Hosseini, S. A. (2015). Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation. International journal of organ transplantation medicine, 6(1), 14-22.
Musavi, Z, et al. "Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation." International journal of organ transplantation medicine vol. 6,1 (2015): 14-22.
Musavi Z, Azarpira N, Sangtarash MH, Kordi M, Kazemi K, Geramizadeh B, Malek-Hosseini SA. Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation. Int J Organ Transplant Med. 2015;6(1):14-22. PMID: 25737773; PMCID: PMC4346459.
Copy Download .nbib Format: NLM
Share it on

Int J Organ Transplant Med. 2015;6(1):14-22.

Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation.

International journal of organ transplantation medicine

Z Musavi, N Azarpira, M H Sangtarash, M Kordi, K Kazemi, B Geramizadeh, S A Malek-Hosseini

Affiliations

  1. Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ; Department of Genetic, Sistan and Baluchestan University of Sciences, Zahedan, Iran.
  2. Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  3. Department of Genetic, Sistan and Baluchestan University of Sciences, Zahedan, Iran.

PMID: 25737773 PMCID: PMC4346459

Abstract

BACKGROUND: New-onset diabetes after transplantation (NODAT) is a serious complication in transplant recipients. Transcription factor-7-like 2 (TCF7L2) is a Wnt signaling-associated transcription factor that plays an important role in β-cell proliferation and insulin secretion. The association between TCF7L2 SNP rs7903146 and NODAT was documented in renal transplant patients.

OBJECTIVE: To determine the association between TCF7L2 rs7903146 variants and the risk of NODAT after liver transplantation.

METHODS: This study was conducted on 140 liver transplant recipients who had received tacrolimus-based immunosuppressive drugs. The patients were divided into NODAT (n=70) and non-NODAT (n=70) groups and were genotyped using PCR-RFLP. In addition, 100 normal subjects were considered as the comparison group.

RESULTS: There was a significant difference (p<0.05) between the two study groups regarding donor and recipient age, recipient body mass index, and recipient fasting plasma glucose before the transplantation. No significant relationship was observed between TCF7L2 rs7903146 genotypes and development of NODAT. No significant difference was also found between the two groups in terms of the tacrolimus and mycophenolate mofetil daily dosage as well as tacrolimus blood level. However, the prednisolone daily dosage was significantly (p=0.01) higher in the NODAT group compared to those without NODAT. The majority of the patients in the NODAT group also had an episode of acute rejection. Furthermore, a significant difference was found between the transplant recipients and the comparison subjects regarding T allele (p<0.001, OR=1.96) and TT genotype (p<0.001, OR=3.47) frequencies.

CONCLUSION: No correlation was found between TCF7L2 genotypes and development of NODAT. Acute rejection and prednisolone pulse therapy predisposed the susceptible patients to NODAT.

Keywords: Diabetes mellitus; Liver transplantation; Polymorphism; Transcription factor 7-like 2 protein; Transcription factors; genetic

References

  1. Diabetes. 2006 Sep;55(9):2654-9 - PubMed
  2. Diabetes Care. 2004 Mar;27(3):805-12 - PubMed
  3. Eur J Hum Genet. 2013 Oct;21(10):1146-51 - PubMed
  4. J Hepatol. 2013 Feb;58(2):271-7 - PubMed
  5. Nat Genet. 2006 Mar;38(3):320-3 - PubMed
  6. Am J Epidemiol. 2012 Dec 1;176(11):995-1001 - PubMed
  7. Nat Genet. 2007 Feb;39(2):218-25 - PubMed
  8. Mol Biol Rep. 2014 Sep;41(9):6063-9 - PubMed
  9. Diabetologia. 2007 Dec;50(12):2443-50 - PubMed
  10. Eur J Clin Pharmacol. 2012 Dec;68(12):1587-94 - PubMed
  11. PLoS One. 2013;8(4):e60212 - PubMed
  12. Hepatology. 2009 Feb;49(2):426-35 - PubMed
  13. J Am Soc Nephrol. 2009 Nov;20(11):2459-67 - PubMed
  14. Transplantation. 2001 Sep 27;72(6):1066-72 - PubMed
  15. Am J Transplant. 2012 Mar;12(3):531-8 - PubMed
  16. Genet Mol Biol. 2010 Jul;33(3):449-51 - PubMed
  17. Nat Genet. 2010 Jul;42(7):579-89 - PubMed
  18. Biochem Soc Trans. 2008 Jun;36(Pt 3):357-9 - PubMed
  19. Transpl Int. 2009 May;22(5):519-30 - PubMed
  20. Transplantation. 2005 Jun 15;79(11):1465-9 - PubMed
  21. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6247-52 - PubMed
  22. Nature. 2007 Feb 22;445(7130):881-5 - PubMed
  23. Diabetes. 2009 Apr;58(4):894-905 - PubMed
  24. Arq Bras Endocrinol Metabol. 2012 Nov;56(8):479-84 - PubMed
  25. Transplant Proc. 2009 Dec;41(10):4172-7 - PubMed
  26. Am J Transplant. 2003 Feb;3(2):178-85 - PubMed
  27. Transplantation. 2003 May 27;75(10 Suppl):SS3-24 - PubMed
  28. Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):391-6 - PubMed
  29. J Mol Med (Berl). 2007 Jul;85(7):777-82 - PubMed
  30. Clin Transplant. 2011 Nov-Dec;25(6):885-91 - PubMed

Publication Types