Display options
Cite
Umamageswari MS, Maniyar YA. Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals. J Clin Diagn Res. 2015;9(1):FF01-3doi: 10.7860/JCDR/2015/10777.5428.
Umamageswari, M. S., & Maniyar, Y. A. (2015). Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals. Journal of clinical and diagnostic research : JCDR, 9(1), FF01-3. https://doi.org/10.7860/JCDR/2015/10777.5428
Umamageswari, M S, and Maniyar, Yasmeen A. "Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals." Journal of clinical and diagnostic research : JCDR vol. 9,1 (2015): FF01-3. doi: https://doi.org/10.7860/JCDR/2015/10777.5428
Umamageswari MS, Maniyar YA. Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals. J Clin Diagn Res. 2015 Jan;9(1):FF01-3. doi: 10.7860/JCDR/2015/10777.5428. Epub 2015 Jan 01. PMID: 25738003; PMCID: PMC4347094.
Copy Download .nbib Format: NLM
Share it on

J Clin Diagn Res. 2015 Jan;9(1):FF01-3. doi: 10.7860/JCDR/2015/10777.5428. Epub 2015 Jan 01.

Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals.

Journal of clinical and diagnostic research : JCDR

M S Umamageswari, Yasmeen A Maniyar

Affiliations

  1. Assistant Professor, Department of Pharmacology, Karpagam Faculty of Medical Sciences and Research , Coimbatore, India .
  2. Professor & HOD, Department of Pharmacology, S Nigalingappa Medical College , Bagalkot, Karnataka, India .

PMID: 25738003 PMCID: PMC4347094 DOI: 10.7860/JCDR/2015/10777.5428

Abstract

INTRODUCTION: Aqueous extract of leaves of Solanum melongena Linn was investigated for its anti-inflammatory activity.

MATERIALS AND METHODS: Acute oral toxicity study according to OECD425 guidelines was done to find out the LD50 of test drug. Carrageenan induced paw oedema method in Wistar Albino rats were used in this study. Aspirin in the dose of 300mg/kg was used as the standard drug and three doses of aqueous extract of leaves of Solanum melongena L. (100mg/kg, 200mg/kg, 400mg/kg b.w.) was used as the test drug. The results were measured at 1(st) h, 3(rd) h, and 5(th) h after the carrageenan injection.

RESULTS: In acute oral toxicity study none of the animals died at the dose of 2000mg/kg. Aqueous extract of Solanum melongena Linn leaf in the dose of 200mg/kg showed significant anti-inflammatory activity (p <0.05) at 3(rd) hr and highly significant anti-inflammatory activity (p<0.001) at 5(th) hr; in the dose of 400 mg/kg, test drug showed p<0.01 at 3(rd) and p<0.001 at 5(th) hr and in the dose of 100mg/kg it showed significant (p<0.05) anti-inflammatory activity at 5(th) hr. In doses of 200mg/kg and 400 mg/kg of aqueous extract of S. melongena L showed the percentage of inhibition of 42.62% which is less than the standard drug aspirin which showed 64.5% inhibition.

CONCLUSION: Aqueous extract of leaves of Solanum melongena Linn has anti-inflammatory activity.

Keywords: Anti-inflammatory activity; LD 50; Solanum melongena

References

  1. ScientificWorldJournal. 2014 Feb 09;2014:719486 - PubMed
  2. J Pharmacol Exp Ther. 1969 Mar;166(1):96-103 - PubMed
  3. J Ayurveda Integr Med. 2012 Apr;3(2):70-4 - PubMed
  4. J Ethnopharmacol. 2003 Jun;86(2-3):135-8 - PubMed
  5. Proc Soc Exp Biol Med. 1962 Dec;111:544-7 - PubMed
  6. Clin Chim Acta. 2003 Feb;328(1-2):39-44 - PubMed
  7. J Ethnopharmacol. 2007 May 4;111(2):335-40 - PubMed
  8. J Ethnopharmacol. 2005 Aug 22;100(1-2):80-4 - PubMed

Publication Types