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Sandhiya S, Dkhar SA, Pillai AA, et al. Comparison of ranolazine and trimetazidine on glycemic status in diabetic patients with coronary artery disease - a randomized controlled trial. J Clin Diagn Res. 2015;9(1):OC01-5doi: 10.7860/JCDR/2015/10594.5448.
Sandhiya, S., Dkhar, S. A., Pillai, A. A., George, M., Jayaraman, B., & Chandrasekaran, A. (2015). Comparison of ranolazine and trimetazidine on glycemic status in diabetic patients with coronary artery disease - a randomized controlled trial. Journal of clinical and diagnostic research : JCDR, 9(1), OC01-5. https://doi.org/10.7860/JCDR/2015/10594.5448
Sandhiya, Selvarajan, et al. "Comparison of ranolazine and trimetazidine on glycemic status in diabetic patients with coronary artery disease - a randomized controlled trial." Journal of clinical and diagnostic research : JCDR vol. 9,1 (2015): OC01-5. doi: https://doi.org/10.7860/JCDR/2015/10594.5448
Sandhiya S, Dkhar SA, Pillai AA, George M, Jayaraman B, Chandrasekaran A. Comparison of ranolazine and trimetazidine on glycemic status in diabetic patients with coronary artery disease - a randomized controlled trial. J Clin Diagn Res. 2015 Jan;9(1):OC01-5. doi: 10.7860/JCDR/2015/10594.5448. Epub 2015 Jan 01. PMID: 25738014; PMCID: PMC4347105.
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J Clin Diagn Res. 2015 Jan;9(1):OC01-5. doi: 10.7860/JCDR/2015/10594.5448. Epub 2015 Jan 01.

Comparison of ranolazine and trimetazidine on glycemic status in diabetic patients with coronary artery disease - a randomized controlled trial.

Journal of clinical and diagnostic research : JCDR

Selvarajan Sandhiya, Steven Aibor Dkhar, Ajith Ananthakrishna Pillai, Melvin George, Balachander Jayaraman, Adithan Chandrasekaran

Affiliations

  1. Assistant Professor, Department of Clinical Pharmacology, JIPMER , Puducherry, India .
  2. Professor, Department of Pharmacology, JIPMER , Puducherry, India .
  3. Associate Professor, Department of Cardiology, JIPMER , Puducherry, India .
  4. Assistant Professor, Cardiac Clinical Trials, Department of Cardiology, SRM Medical College Hospital & Research Centre , Kattankulathur, Chennai, India .
  5. Professor, Department of Cardiology, JIPMER , Puducherry, India .
  6. Senior Professor & Head, Department of Clinical Pharmacology, JIPMER , Puducherry, India .

PMID: 25738014 PMCID: PMC4347105 DOI: 10.7860/JCDR/2015/10594.5448

Abstract

INTRODUCTION: Cardiovascular diseases have become the leading cause of death around the globe and diabetes mellitus (DM) is considered to be a coronary artery disease (CAD) risk equivalent. Ranolazine, an anti anginal drug has been found to reduce Glycated haemoglobin (HbA1c) in diabetes patients with chronic angina. However the effect of another antianginal drug trimetazidine, on glycemic status is not clear.

AIM: To compare the effect of ranolazine and trimetazidine on glycemic status in diabetic patients with CAD.

SETTINGS AND DESIGN: Patients diagnosed with CAD and diabetes mellitus attending Cardiology Out Patient Department (OPD), Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India were recruited for this randomized open label parallel arm trial.

MATERIALS AND METHODS: The study conducted from January-2012 to April-2013 had 47 eligible patients diagnosed with CAD and diabetes mellitus. They were randomized to receive either ranolazine 500 mg BD or trimetazidine 35 mg BD for 12 weeks. HbA1c levels, fasting blood glucose (FBG), lipid profile, QT and QTc intervals were measured at baseline and after 12 weeks.

STATISTICAL ANALYSIS: Unpaired t-test was used to compare the baseline characteristics of between the groups while comparison within the groups were done using Paired t-test. Wilcoxon and Mann Whitney U-tests were used for non parametric data. Graph pad instat version-3 was used for statistical analysis. Values were expressed as mean ± SD. A p < 0.05 was considered statistically significant.

RESULTS: The study could not find any change in HbA1c levels in both ranolazine and trimetazidine groups. The adverse effects reported from patients on ranolazine include angina, constipation, postural hypotension, headache, dizziness, nausea and weakness while patients on trimetazidine complained of constipation, weakness, palpitations, angina, dizziness, nausea, dyspepsia, headache, gastric discomfort, joint pain, etc.

CONCLUSION: In patients with chronic angina and diabetes mellitus Ranolazine 500mg BD and Trimetazidine 35mg BD did not show any effect on HbA1c and fasting blood glucose lebel.

Keywords: Glycemic status; HbA1c; QTc; Ranolazine; Trimetazidine

References

  1. J Am Coll Cardiol. 2006 Aug 1;48(3):566-75 - PubMed
  2. J Pharmacol Exp Ther. 2011 Apr;337(1):50-8 - PubMed
  3. Am J Ther. 2005 Jan-Feb;12(1):35-42 - PubMed
  4. Clin Trials Metaanal. 1994 Apr;29(1):49-56 - PubMed
  5. Eur Heart J. 2006 Jan;27(1):42-8 - PubMed
  6. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):31-6 - PubMed
  7. Br J Clin Pharmacol. 1994 Mar;37(3):279-88 - PubMed
  8. J Diabetes Sci Technol. 2010 Jan 01;4(1):158-70 - PubMed
  9. N Engl J Med. 1998 Jul 23;339(4):229-34 - PubMed
  10. Am J Cardiol. 2012 Nov 6;110(9 Suppl):58B-68B - PubMed
  11. Circulation. 1998 Feb 17;97(6):596-601 - PubMed
  12. J Am Coll Cardiol. 2004 Apr 21;43(8):1375-82 - PubMed
  13. Eur Heart J. 2001 Dec;22(24):2267-74 - PubMed
  14. Diabetes Care. 2010 Jun;33(6):1163-8 - PubMed
  15. JAMA. 2007 Apr 25;297(16):1775-83 - PubMed
  16. J Cardiovasc Pharmacol Ther. 2004 Sep;9 Suppl 1:S47-64 - PubMed
  17. Am Heart J. 2007 Jul;154(1):78.e1-7 - PubMed
  18. J Am Coll Cardiol. 2013 May 21;61(20):2038-45 - PubMed
  19. Circulation. 2009 Apr 21;119(15):2032-9 - PubMed
  20. Am J Ther. 2003 Nov-Dec;10(6):444-6 - PubMed
  21. Vasc Health Risk Manag. 2008;4(4):819-24 - PubMed
  22. Int J Hypertens. 2012;2012:697240 - PubMed
  23. Cardiovasc Drugs Ther. 1999 May;13(3):217-22 - PubMed
  24. Wien Med Wochenschr. 2010 Jan;160(1-2):8-19 - PubMed
  25. Am J Cardiol. 2008 Dec 22;102(12A):5L-9L - PubMed
  26. Coron Artery Dis. 2003 Apr;14(2):171-9 - PubMed
  27. JAMA. 2004 Jan 21;291(3):309-16 - PubMed
  28. Diabetes. 2006 Jun;55(6):1695-704 - PubMed
  29. J Am Coll Cardiol. 2007 Mar 13;49(10):1027-34 - PubMed
  30. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):24-30 - PubMed

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