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Lehr M, Fabian J, Hanekamp W. Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones. Biopharm Drug Dispos. 2015;36(6):398-404doi: 10.1002/bdd.1946.
Lehr, M., Fabian, J., & Hanekamp, W. (2015). Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones. Biopharmaceutics & drug disposition, 36(6), 398-404. https://doi.org/10.1002/bdd.1946
Lehr, Matthias, et al. "Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones." Biopharmaceutics & drug disposition vol. 36,6 (2015): 398-404. doi: https://doi.org/10.1002/bdd.1946
Lehr M, Fabian J, Hanekamp W. Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones. Biopharm Drug Dispos. 2015 Sep;36(6):398-404. doi: 10.1002/bdd.1946. Epub 2015 Apr 14. PMID: 25765813.
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Biopharm Drug Dispos. 2015 Sep;36(6):398-404. doi: 10.1002/bdd.1946. Epub 2015 Apr 14.

Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones.

Biopharmaceutics & drug disposition

Matthias Lehr, Jörg Fabian, Walburga Hanekamp

Affiliations

  1. Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Germany.

PMID: 25765813 DOI: 10.1002/bdd.1946

Abstract

Recently, it was found that the carbonyl group of 1-[3-(4-phenoxyphenoxy)-2-oxopropyl]indole-5-carboxylic acid (5), an inhibitor of the pro-inflammatory enzyme cytosolic phospholipase A

Copyright © 2015 John Wiley & Sons, Ltd.

Keywords: NADPH-cytochrome P450 reductase; carbonyl reductase-1; daunorubicin; haloperidol; keto-reduction

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