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Ribeiro RM, Pinheiro Neto VF, Ribeiro KS, et al. Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats. Evid Based Complement Alternat Med. 2014;2014:605452doi: 10.1155/2014/605452.
Ribeiro, R. M., Pinheiro Neto, V. F., Ribeiro, K. S., Vieira, D. A., Abreu, I. C., Silva, S. d. o. . N., Cartágenes, M. d. o. . S., Freire, S. M., Borges, A. C., & Borges, M. O. (2014). Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats. Evidence-based complementary and alternative medicine : eCAM, 2014605452. https://doi.org/10.1155/2014/605452
Ribeiro, Rachel Melo, et al. "Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats." Evidence-based complementary and alternative medicine : eCAM vol. 2014 (2014): 605452. doi: https://doi.org/10.1155/2014/605452
Ribeiro RM, Pinheiro Neto VF, Ribeiro KS, Vieira DA, Abreu IC, Silva Sdo N, Cartágenes Mdo S, Freire SM, Borges AC, Borges MO. Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats. Evid Based Complement Alternat Med. 2014;2014:605452. doi: 10.1155/2014/605452. Epub 2014 Dec 28. PMID: 25614751; PMCID: PMC4295347.
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Evid Based Complement Alternat Med. 2014;2014:605452. doi: 10.1155/2014/605452. Epub 2014 Dec 28.

Antihypertensive Effect of Syzygium cumini in Spontaneously Hypertensive Rats.

Evidence-based complementary and alternative medicine : eCAM

Rachel Melo Ribeiro, Vicente Férrer Pinheiro Neto, Kllysmann Santos Ribeiro, Denilson Amorim Vieira, Iracelle Carvalho Abreu, Selma do Nascimento Silva, Maria do Socorro de Sousa Cartágenes, Sônia Maria de Farias Freire, Antonio Carlos Romão Borges, Marilene Oliveira da Rocha Borges

Affiliations

  1. Laboratory of Pharmacology, Department of Physiological Science, Federal University of Maranhão (UFMA), Avenida dos Portugueses 1966, Bacanga, 65080-805 São Luís, MA, Brazil.
  2. Department of Veterinary Medicine, State University of Maranhão (UEMA), 65055-970 São Luís, MA, Brazil.

PMID: 25614751 PMCID: PMC4295347 DOI: 10.1155/2014/605452

Abstract

This study evaluated the in vivo potential antihypertensive effect of hydroalcoholic extract of Syzygium cumini leaves (HESC) in normotensive Wistar rats and in spontaneously hypertensive rats (SHR), as well as its in vitro effect on the vascular reactivity of resistance arteries. The hypotensive effect caused by intravenous infusion of HESC (0.01-4.0 mg/kg) in anesthetized Wistar rats was dose-dependent and was partially inhibited by pretreatment with atropine sulfate. SHR received HESC (0.5 g/kg/day), orally, for 8 weeks and mean arterial pressure, heart rate, and vascular reactivity were evaluated. Daily oral administration of HESC resulted in a time-dependent blood pressure reduction in SHR, with a maximum reduction of 62%. In the endothelium-deprived superior mesenteric arteries rings the treatment with HESC reduced by 40% the maximum effect (E max⁡) of contraction induced by NE. The contractile response to calcium and NE of endothelium-deprived mesenteric rings isolated from untreated SHR was reduced in a concentration-dependent manner by HESC (0.1, 0.25, and 0.5 mg/mL). This study demonstrated that Syzygium cumini reduces the blood pressure and heart rate of SHR and that this antihypertensive effect is probably due to the inhibition of arterial tone and extracellular calcium influx.

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