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Chen S, Wang S, Rong P, et al. Acupuncture for visceral pain: neural substrates and potential mechanisms. Evid Based Complement Alternat Med. 2014;2014:609594doi: 10.1155/2014/609594.
Chen, S., Wang, S., Rong, P., Wang, J., Qiao, L., Feng, X., Liu, J., & Zhang, J. (2014). Acupuncture for visceral pain: neural substrates and potential mechanisms. Evidence-based complementary and alternative medicine : eCAM, 2014609594. https://doi.org/10.1155/2014/609594
Chen, Shuping, et al. "Acupuncture for visceral pain: neural substrates and potential mechanisms." Evidence-based complementary and alternative medicine : eCAM vol. 2014 (2014): 609594. doi: https://doi.org/10.1155/2014/609594
Chen S, Wang S, Rong P, Wang J, Qiao L, Feng X, Liu J, Zhang J. Acupuncture for visceral pain: neural substrates and potential mechanisms. Evid Based Complement Alternat Med. 2014;2014:609594. doi: 10.1155/2014/609594. Epub 2014 Dec 29. PMID: 25614752; PMCID: PMC4295157.
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Evid Based Complement Alternat Med. 2014;2014:609594. doi: 10.1155/2014/609594. Epub 2014 Dec 29.

Acupuncture for visceral pain: neural substrates and potential mechanisms.

Evidence-based complementary and alternative medicine : eCAM

Shuping Chen, Shubin Wang, Peijing Rong, Junying Wang, Lina Qiao, Xiumei Feng, Junling Liu, Jianliang Zhang

Affiliations

  1. Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
  2. Department of Acupuncture, China General Meitan Hospital, Beijing 100028, China.

PMID: 25614752 PMCID: PMC4295157 DOI: 10.1155/2014/609594

Abstract

Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. Despite much advances, the pathophysiological mechanism is still poorly understood comparing with its somatic counterpart and, as a result, the therapeutic efficacy is usually unsatisfactory. Acupuncture has long been used for the management of numerous disorders in particular pain and visceral pain, characterized by the high therapeutic benefits and low adverse effects. Previous findings suggest that acupuncture depresses pain via activation of a number of neurotransmitters or modulators including opioid peptides, serotonin, norepinephrine, and adenosine centrally and peripherally. It endows us, by advancing the understanding of the role of ion channels and gut microbiota in pain process, with novel perspectives to probe the mechanisms underlying acupuncture analgesia. In this review, after describing the visceral innervation and the relevant afferent pathways, in particular the ion channels in visceral nociception, we propose three principal mechanisms responsible for acupuncture induced benefits on visceral pain. Finally, potential topics are highlighted regarding the future studies in this field.

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