50 yr at the time of diagnosis were categorized as the "typical-onset" (TOPD) patients (n = 95). Different questionnaires and scales were used for between-group comparisons including PDQ39, HADS (hospital anxiety and depression scale), FSS (fatigue severity scale), MNA (mininutritional assessment), and the UPDRS. Depression score was significantly higher in EOPD group (6.3 (SD = 4.5) versus 4.5 (SD = 4.2), P = 0.02). Among different domains of QoL, emotion score was also significantly higher in the EOPD group (32.3 (SD = 21.6) versus 24.4 (SD = 22.7), P = 0.05). Our findings showed more severe depression and more impaired emotional domain of QoL in early-onset PD patients. Depression and anxiety play an important role to worsen QoL among both EOPD and TOPD patients, while no interaction was observed in the efficacy of these two psychiatric symptoms and the onset age of PD patients. " />
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Fereshtehnejad SM, Hadizadeh H, Farhadi F, et al. Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson's Disease Patients. Parkinsons Dis. 2014;2014:819260doi: 10.1155/2014/819260.
Fereshtehnejad, S. M., Hadizadeh, H., Farhadi, F., Shahidi, G. A., Delbari, A., & Lökk, J. (2014). Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson's Disease Patients. Parkinson's disease, 2014819260. https://doi.org/10.1155/2014/819260
Fereshtehnejad, Seyed-Mohammad, et al. "Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson's Disease Patients." Parkinson's disease vol. 2014 (2014): 819260. doi: https://doi.org/10.1155/2014/819260
Fereshtehnejad SM, Hadizadeh H, Farhadi F, Shahidi GA, Delbari A, Lökk J. Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson's Disease Patients. Parkinsons Dis. 2014;2014:819260. doi: 10.1155/2014/819260. Epub 2014 Dec 29. PMID: 25614849; PMCID: PMC4295150.
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Parkinsons Dis. 2014;2014:819260. doi: 10.1155/2014/819260. Epub 2014 Dec 29.

Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson's Disease Patients.

Parkinson's disease

Seyed-Mohammad Fereshtehnejad, Hasti Hadizadeh, Farzaneh Farhadi, Gholam Ali Shahidi, Ahmad Delbari, Johan Lökk

Affiliations

  1. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Novum 5th Floor, 14186 Stockholm, Sweden ; Firoozgar Clinical Research Development Center (FCRDC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran 15937-48711, Iran.
  2. Medical Student Research Committee (MSRC), Faculty of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
  3. Movement Disorders Clinic, Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
  4. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Novum 5th Floor, 14186 Stockholm, Sweden ; Iranian Research Center on Aging, University of Social Welfare and Rehabilitation, Tehran 19857-13834, Iran.
  5. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Novum 5th Floor, 14186 Stockholm, Sweden ; Department of Geriatric Medicine, Karolinska University Hospital, 14186 Stockholm, Sweden.

PMID: 25614849 PMCID: PMC4295150 DOI: 10.1155/2014/819260

Abstract

The impact of Parkinson's disease (PD) on psychological status and quality of life (QoL) may vary depending on age of disease onset. The aim of this study was to compare psychological symptoms and disease-specific QoL between early onset versus the rest of the PD patients. A total number of 140 PD patients with the mean current age of 61.3 (SD = 10.4) yr were recruited in this study. PD patients with the onset age of ≤50 yr were defined as "early-onset" (EOPD) group (n = 45), while the ones with >50 yr at the time of diagnosis were categorized as the "typical-onset" (TOPD) patients (n = 95). Different questionnaires and scales were used for between-group comparisons including PDQ39, HADS (hospital anxiety and depression scale), FSS (fatigue severity scale), MNA (mininutritional assessment), and the UPDRS. Depression score was significantly higher in EOPD group (6.3 (SD = 4.5) versus 4.5 (SD = 4.2), P = 0.02). Among different domains of QoL, emotion score was also significantly higher in the EOPD group (32.3 (SD = 21.6) versus 24.4 (SD = 22.7), P = 0.05). Our findings showed more severe depression and more impaired emotional domain of QoL in early-onset PD patients. Depression and anxiety play an important role to worsen QoL among both EOPD and TOPD patients, while no interaction was observed in the efficacy of these two psychiatric symptoms and the onset age of PD patients.

References

  1. J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4 - PubMed
  2. Neurology. 1967 May;17(5):427-42 - PubMed
  3. Mov Disord. 1998 Nov;13(6):885-94 - PubMed
  4. Age Ageing. 1999 Jul;28(4):341-6 - PubMed
  5. Qual Life Res. 2009 Sep;18(7):833-9 - PubMed
  6. Parkinsons Dis. 2013;2013:935429 - PubMed
  7. J Neurol Neurosurg Psychiatry. 2000 Sep;69(3):308-12 - PubMed
  8. J Neurol. 1998 May;245 Suppl 1:S10-4 - PubMed
  9. Health Qual Life Outcomes. 2014 May 20;12:78 - PubMed
  10. Synapse. 2003 Feb;47(2):152-8 - PubMed
  11. J Am Geriatr Soc. 2002 Dec;50(12):1996-2002 - PubMed
  12. Neurology. 2008 Jun 3;70(23):2241-7 - PubMed
  13. Health Qual Life Outcomes. 2003 Apr 28;1:14 - PubMed
  14. Parkinsonism Relat Disord. 2002 Jan;8(3):193-7 - PubMed
  15. Acta Psychiatr Scand. 1983 Jun;67(6):361-70 - PubMed
  16. J Neurol Neurosurg Psychiatry. 1999 Apr;66(4):431-5 - PubMed
  17. J Neurol Neurosurg Psychiatry. 1994 Oct;57(10):1265-7 - PubMed
  18. J Psychiatr Res. 1975 Nov;12(3):189-98 - PubMed
  19. J Psychosom Res. 1997 Jan;42(1):17-41 - PubMed
  20. Mov Disord. 2003 Jul;18(7):738-50 - PubMed
  21. Eur J Neurol. 2009 Apr;16(4):450-6 - PubMed
  22. Mov Disord. 2000 Mar;15(2):216-23 - PubMed
  23. J Res Med Sci. 2010 Mar;15(2):63-9 - PubMed
  24. Soc Sci Med. 1974 Mar;8(3):143-51 - PubMed
  25. Mov Disord. 2011 Sep;26(11):2011-8 - PubMed
  26. Arch Neurol. 1989 Oct;46(10):1121-3 - PubMed
  27. Neurology. 1989 Nov;39(11):1441-5 - PubMed
  28. Mov Disord. 2003 Nov;18(11):1250-6 - PubMed
  29. Neurology. 2002 Apr 23;58(8):1239-46 - PubMed
  30. Lancet Neurol. 2006 Apr;5(4):355-63 - PubMed

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