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Novick D, Montgomery W, Moneta V, et al. Antidepressant medication treatment patterns in Asian patients with major depressive disorder. Patient Prefer Adherence. 2015;9:421-8doi: 10.2147/PPA.S68432.
Novick, D., Montgomery, W., Moneta, V., Peng, X., Brugnoli, R., & Haro, J. M. (2015). Antidepressant medication treatment patterns in Asian patients with major depressive disorder. Patient preference and adherence, 9421-8. https://doi.org/10.2147/PPA.S68432
Novick, Diego, et al. "Antidepressant medication treatment patterns in Asian patients with major depressive disorder." Patient preference and adherence vol. 9 (2015): 421-8. doi: https://doi.org/10.2147/PPA.S68432
Novick D, Montgomery W, Moneta V, Peng X, Brugnoli R, Haro JM. Antidepressant medication treatment patterns in Asian patients with major depressive disorder. Patient Prefer Adherence. 2015 Mar 11;9:421-8. doi: 10.2147/PPA.S68432. eCollection 2015. PMID: 25792815; PMCID: PMC4362981.
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Patient Prefer Adherence. 2015 Mar 11;9:421-8. doi: 10.2147/PPA.S68432. eCollection 2015.

Antidepressant medication treatment patterns in Asian patients with major depressive disorder.

Patient preference and adherence

Diego Novick, William Montgomery, Victoria Moneta, Xiaomei Peng, Roberto Brugnoli, Josep Maria Haro

Affiliations

  1. Eli Lilly and Company, Windlesham, Surrey, UK.
  2. Eli Lilly Australia Pty Ltd, West Ryde, Australia.
  3. Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
  4. Eli Lilly and Company, Indianapolis, IN, USA.
  5. Department of Neuroscience, School of Medicine, Sapienza University of Rome, Rome, Italy.

PMID: 25792815 PMCID: PMC4362981 DOI: 10.2147/PPA.S68432

Abstract

PURPOSE: To describe pharmacological treatment patterns in Asian patients with major depressive disorder (MDD), including duration of treatment, reasons for medication discontinuation, rate of medication nonadherence, factors associated with medication nonadherence, and impact of medication nonadherence on depression outcomes.

PATIENTS AND METHODS: Data were from a prospective, observational 3-month study of East Asian MDD inpatients from 40 sites in six East Asian countries who initiated antidepressant treatment at baseline (n=569). Assessments included the Clinical Global Impression-Severity scale (CGI-S), 17-item Hamilton Depression Rating Scale (HAMD-17), painful physical symptoms, response and remission, employment status, quality of life (QoL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) and health state using the visual analog scale, adherence by clinician opinion, and patient self-report. Cox proportional hazards modeling, Kaplan-Meier survival analysis, and regression modeling were employed.

RESULTS: Median time to discontinuation for any reason was 70 days (95% confidence interval: 47; 95). Reasons for discontinuation were inadequate response in 64.1%, nonadherence in 6.2%, and adverse events in 4.1%; 25.6% who discontinued experienced an adequate response to treatment. In those patients who had an adequate response, age and country were significantly associated with time to medication discontinuation. Patient-reported nonadherence was 57.5% and clinician-reported nonadherence was 14.6% (62/426). At 3 months, nonadherent patients had significantly higher disease severity (CGI-S, P=0.0001; HAMD-17, P<0.0001), lower QoL ratings (EQ-5D tariff, P=0.0007; EQ-5D visual analog scale, P=0.0024), and lower response and remission rates (both P<0.0001) compared with adherent patients. The odds of response and remission were greater among adherent patients.

CONCLUSION: Early discontinuation of antidepressants among Asian MDD patients was high. A total of 25.6% who discontinued prematurely were experiencing an adequate response to treatment. Nonadherent patients had significantly higher disease severity, lower QoL ratings, and lower response and remission rates compared with adherent patients.

Keywords: Asian; adherence; major depressive disorder; treatment

References

  1. Psychiatry Investig. 2009 Dec;6(4):255-63 - PubMed
  2. Med Care. 2005 Dec;43(12):1203-7 - PubMed
  3. Patient Prefer Adherence. 2013;7:151-69 - PubMed
  4. Arch Gen Psychiatry. 1998 Dec;55(12):1128-32 - PubMed
  5. J Affect Disord. 2010 Jun;123(1-3):216-21 - PubMed
  6. BMC Psychiatry. 2009 Jun 16;9:38 - PubMed
  7. Issues Ment Health Nurs. 2008 Jul;29(7):701-17 - PubMed
  8. J Clin Psychopharmacol. 2010 Dec;30(6):716-9 - PubMed
  9. Int J Clin Pract. 2009 Jul;63(7):1041-9 - PubMed
  10. Arch Fam Med. 1994 Sep;3(9):774-9 - PubMed
  11. BMC Psychiatry. 2007 Aug 28;7:43 - PubMed
  12. Fam Pract. 2004 Dec;21(6):623-9 - PubMed
  13. Psychiatry Res. 2012 May 30;197(3):221-6 - PubMed
  14. Curr Med Res Opin. 2011 Oct;27(10):1849-58 - PubMed
  15. Am J Psychiatry. 2006 Jan;163(1):101-8 - PubMed
  16. Psychiatr Danub. 2010 Sep;22(3):413-7 - PubMed
  17. Ann Fam Med. 2005 Jan-Feb;3(1):23-30 - PubMed
  18. Psychiatry Clin Neurosci. 2010 Apr;64(2):179-86 - PubMed
  19. Int J Clin Pract. 2007 Aug;61(8):1283-93 - PubMed
  20. BMJ. 1999 Sep 4;319(7210):612-5 - PubMed
  21. Compr Psychiatry. 2011 Jul-Aug;52(4):370-7 - PubMed
  22. JAMA. 2002 Sep 18;288(11):1403-9 - PubMed
  23. Ann Pharmacother. 2002 Apr;36(4):578-84 - PubMed
  24. J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 - PubMed
  25. Psychiatry Clin Neurosci. 2011 Dec;65(7):630-7 - PubMed
  26. BMC Psychiatry. 2010 Aug 22;10:64 - PubMed
  27. Gen Hosp Psychiatry. 2013 May-Jun;35(3):279-85 - PubMed

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