Display options
Cite
Townsend JR, Hoffman JR, Gonzalez AM, et al. Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response. Int J Endocrinol. 2015;2015:856708doi: 10.1155/2015/856708.
Townsend, J. R., Hoffman, J. R., Gonzalez, A. M., Jajtner, A. R., Boone, C. H., Robinson, E. H., Mangine, G. T., Wells, A. J., Fragala, M. S., Fukuda, D. H., & Stout, J. R. (2015). Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response. International journal of endocrinology, 2015856708. https://doi.org/10.1155/2015/856708
Townsend, Jeremy R, et al. "Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response." International journal of endocrinology vol. 2015 (2015): 856708. doi: https://doi.org/10.1155/2015/856708
Townsend JR, Hoffman JR, Gonzalez AM, Jajtner AR, Boone CH, Robinson EH, Mangine GT, Wells AJ, Fragala MS, Fukuda DH, Stout JR. Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response. Int J Endocrinol. 2015;2015:856708. doi: 10.1155/2015/856708. Epub 2015 Feb 22. PMID: 25792982; PMCID: PMC4352513.
Copy Download .nbib Format: NLM
Share it on

Int J Endocrinol. 2015;2015:856708. doi: 10.1155/2015/856708. Epub 2015 Feb 22.

Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response.

International journal of endocrinology

Jeremy R Townsend, Jay R Hoffman, Adam M Gonzalez, Adam R Jajtner, Carleigh H Boone, Edward H Robinson, Gerald T Mangine, Adam J Wells, Maren S Fragala, David H Fukuda, Jeffrey R Stout

Affiliations

  1. Institute of Exercise Science and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL 32816, USA.

PMID: 25792982 PMCID: PMC4352513 DOI: 10.1155/2015/856708

Abstract

Objective. To examine the endocrine response to a bout of heavy resistance exercise following acute β-hydroxy-β-methylbutyrate free acid (HMB-FA) ingestion. Design. Twenty resistance trained men were randomized and consumed either 1 g of HMB-FA (BetaTor) or placebo (PL) 30 min prior to performing an acute heavy resistance exercise protocol. Blood was obtained before (PRE), immediately after (IP), and 30 min after exercise (30P). Circulating concentrations of testosterone, growth hormone (GH), insulin-like growth factor (IGF-1), and insulin were assayed. Data were analyzed with a repeated measures ANOVA and area under the curve (AUC) was analyzed by the trapezoidal rule. Results. The resistance exercise protocol resulted in significant elevations from PRE in testosterone (P < 0.01), GH (P < 0.01), and insulin (P = 0.05) at IP, with GH (P < 0.01) and insulin (P < 0.01) remaining elevated at 30P. A significant interaction was noted between groups in the plasma GH response at IP, which was significantly higher following HMB-FA compared to PL (P < 0.01). AUC analysis revealed an elevated GH and IGF-1 response in the HMB-FA group compared to PL. Conclusion. HMB-FA prior to resistance exercise augments the GH response to high volume resistance exercise compared to PL. These findings provide further support for the potential anabolic benefits associated with HMB supplementation.

References

  1. Med Sci Sports Exerc. 1992 Dec;24(12):1346-52 - PubMed
  2. Eur J Appl Physiol. 2011 Sep;111(9):2261-9 - PubMed
  3. J Nutr. 2014 Oct;144(10):1549-55 - PubMed
  4. Growth Horm IGF Res. 2011 Apr;21(2):57-62 - PubMed
  5. Nutr Metab (Lond). 2011 Feb 23;8(1):11 - PubMed
  6. J Strength Cond Res. 2016 Jul;30(7):1843-54 - PubMed
  7. Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E923-31 - PubMed
  8. Amino Acids. 2014 Jun;46(6):1501-11 - PubMed
  9. Br J Nutr. 2013 Aug 28;110(3):538-44 - PubMed
  10. J Appl Physiol (1985). 1999 Aug;87(2):498-504 - PubMed
  11. J Physiol. 2013 Jun 1;591(11):2911-23 - PubMed
  12. J Appl Physiol (1985). 2013 Oct 15;115(8):1173-82 - PubMed
  13. J Am Coll Nutr. 2014;33(4):247-55 - PubMed
  14. Eur J Appl Physiol. 2014 Jun;114(6):1217-27 - PubMed
  15. Am J Physiol Regul Integr Comp Physiol. 2014 Apr 1;306(7):R483-9 - PubMed
  16. Nutrition. 2000 Sep;16(9):734-9 - PubMed
  17. Acta Endocrinol (Copenh). 1979 Mar;90(3):403-8 - PubMed
  18. Growth Horm IGF Res. 2005 Apr;15(2):136-9 - PubMed
  19. Curr Med Res Opin. 1981;7(7):475-81 - PubMed
  20. Int J Sport Nutr. 1993 Sep;3(3):306-22 - PubMed
  21. J Strength Cond Res. 2004 Nov;18(4):747-52 - PubMed
  22. Amino Acids. 2011 Apr;40(4):1015-25 - PubMed
  23. Br J Nutr. 2011 Feb;105(3):367-72 - PubMed
  24. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1409-16 - PubMed
  25. J Appl Physiol (1985). 1996 Nov;81(5):2095-104 - PubMed
  26. Phys Sportsmed. 1985 May;13(5):76-90 - PubMed
  27. Int J Sport Nutr. 1993 Sep;3(3):290-7 - PubMed
  28. Anal Biochem. 1990 Jul;188(1):17-9 - PubMed
  29. J Int Soc Sports Nutr. 2013 Feb 02;10(1):6 - PubMed
  30. Growth Horm IGF Res. 2010 Feb;20(1):1-7 - PubMed
  31. J Appl Physiol. 1976 Oct;41(4):523-7 - PubMed
  32. Int J Sport Nutr. 1997 Mar;7(1):48-60 - PubMed
  33. Med Sci Sports Exerc. 2003 Nov;35(11):1929-34 - PubMed
  34. Med Sci Sports Exerc. 2009 May;41(5):1111-21 - PubMed

Publication Types