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Sarfraz RM, Khan HU, Mahmood A, et al. Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin. Indian J Pharm Sci. 2015;77(1):83-90doi: 10.4103/0250-474x.151602.
Sarfraz, R. M., Khan, H. U., Mahmood, A., Ahmad, M., Maheen, S., & Sher, M. (2015). Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin. Indian journal of pharmaceutical sciences, 77(1), 83-90. https://doi.org/10.4103/0250-474x.151602
Sarfraz, R M, et al. "Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin." Indian journal of pharmaceutical sciences vol. 77,1 (2015): 83-90. doi: https://doi.org/10.4103/0250-474x.151602
Sarfraz RM, Khan HU, Mahmood A, Ahmad M, Maheen S, Sher M. Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin. Indian J Pharm Sci. 2015 Jan-Feb;77(1):83-90. doi: 10.4103/0250-474x.151602. PMID: 25767322; PMCID: PMC4355887.
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Indian J Pharm Sci. 2015 Jan-Feb;77(1):83-90. doi: 10.4103/0250-474x.151602.

Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin.

Indian journal of pharmaceutical sciences

R M Sarfraz, H U Khan, A Mahmood, M Ahmad, S Maheen, M Sher

Affiliations

  1. Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.
  2. Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Punjab, Pakistan.
  3. Department of Chemistry, University of Sargodha, Sargodha, 40100, Punjab, Pakistan.

PMID: 25767322 PMCID: PMC4355887 DOI: 10.4103/0250-474x.151602

Abstract

In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used.

Keywords: Atenolol; Kyron-T134; atorvastatin; croscarmellose sodium; mouth-disintegrating tablets

References

  1. J Pharm Pharmacol. 1998 Apr;50(4):375-82 - PubMed
  2. Drug Dev Ind Pharm. 2007 Nov;33(11):1225-32 - PubMed
  3. Chem Pharm Bull (Tokyo). 1996 Nov;44(11):2121-7 - PubMed
  4. AAPS PharmSci. 2004 Mar 22;6(1):E12 - PubMed
  5. J Mater Sci Mater Med. 2010 May;21(5):1621-30 - PubMed
  6. Indian J Pharm Sci. 2008 Jan;70(1):71-6 - PubMed
  7. Drug Dev Ind Pharm. 1999 May;25(5):571-81 - PubMed
  8. Clin Ther. 1998 Jul-Aug;20(4):764-71 - PubMed

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