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Gokavarapu S, Rao S LM, Tantravahi US, et al. Oral hybrid verrucous carcinoma: a clinical study. Indian J Surg Oncol. 2014;5(4):257-62doi: 10.1007/s13193-014-0345-0.
Gokavarapu, S., Rao S, L. M., Tantravahi, U. S., Gundimeda, S. D., Rao, T. S., & Murthy, S. (2014). Oral hybrid verrucous carcinoma: a clinical study. Indian journal of surgical oncology, 5(4), 257-62. https://doi.org/10.1007/s13193-014-0345-0
Gokavarapu, Sandhya, et al. "Oral hybrid verrucous carcinoma: a clinical study." Indian journal of surgical oncology vol. 5,4 (2014): 257-62. doi: https://doi.org/10.1007/s13193-014-0345-0
Gokavarapu S, Rao S LM, Tantravahi US, Gundimeda SD, Rao TS, Murthy S. Oral hybrid verrucous carcinoma: a clinical study. Indian J Surg Oncol. 2014 Dec;5(4):257-62. doi: 10.1007/s13193-014-0345-0. Epub 2014 Aug 28. PMID: 25767335; PMCID: PMC4354831.
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Indian J Surg Oncol. 2014 Dec;5(4):257-62. doi: 10.1007/s13193-014-0345-0. Epub 2014 Aug 28.

Oral hybrid verrucous carcinoma: a clinical study.

Indian journal of surgical oncology

Sandhya Gokavarapu, L M Chandrasekhara Rao S, Uma Sankar Tantravahi, Sandhya Devi Gundimeda, T Subramaneshwar Rao, Sudha Murthy

Affiliations

  1. Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh pin - 500034 India.

PMID: 25767335 PMCID: PMC4354831 DOI: 10.1007/s13193-014-0345-0

Abstract

Hybrid Verrucous Carcinoma is an uncommon tumour wherein Verrucous Carcinoma (VC) is coexisting with conventional Squamous Cell Carcinoma (SCC) within same maternal field. The heterogeneous nature, infrequency of occurrence and the difficulties associated with diagnosis and management of this tumor is discussed through a retrospective study. Patients of primary hybrid VC treated from Jan 2010 to May 2013 at a tertiary institute were analyzed on multivariate cox regression model. During the above mentioned period; 37 patients of hybrid VC were reported; 18(48.6 %) were male and 19(51.3 %) were female. Age ranged between 33 years to 78 years. Median follow up period was 32 months. T stage status and Stage grouping was not statistically significant for mortality (p value: 0.338). In the multivariate cox-regression model, the presence of second primary oral cancer was significantly associated with mortality, adjusted HR; 23.10 (95 % CI: 1.73, 307.65) (p = 0.017). Tumour staging is often unreliable in predicting prognosis of hybrid VC, occurrence of second primary oral cancer and recurrence appears to be significant factors effecting prognosis.

Keywords: Hybrid verrucous carcinoma; Oral cancer; Verrucous carcinoma

References

  1. Cancer Res. 1996 Jun 1;56(11):2484-7 - PubMed
  2. Arch Otolaryngol. 1984 Jul;110(7):437-40 - PubMed
  3. Ear Nose Throat J. 1997 Nov;76(11):818-23 - PubMed
  4. Int J Radiat Oncol Biol Phys. 1989 Sep;17(3):449-56 - PubMed
  5. Oral Oncol. 2009 Apr-May;45(4-5):361-85 - PubMed
  6. Curr Med Res Opin. 2012 Dec;28(12):1899-909 - PubMed
  7. Head Neck Surg. 1982 Sep-Oct;5(1):29-38 - PubMed
  8. Int J Radiat Oncol Biol Phys. 1992;24(1):59-64 - PubMed
  9. J Laryngol Otol. 1983 Jul;97(7):619-21 - PubMed
  10. Head Neck. 1998 Mar;20(2):138-44 - PubMed
  11. Oral Oncol. 2009 Jan;45(1):47-51 - PubMed
  12. Head Neck. 1998 May;20(3):197-203 - PubMed
  13. Oral Oncol. 2011 May;47(5):320-4 - PubMed
  14. Cancer. 1980 Oct 15;46(8):1855-62 - PubMed
  15. Head Neck. 2002 Jun;24(6):513-20 - PubMed
  16. Cancer. 1995 Mar 15;75(6):1343-53 - PubMed
  17. Hum Pathol. 1995 Mar;26(3):251-61 - PubMed
  18. Lab Invest. 1995 Oct;73(4):503-10 - PubMed
  19. J Proteomics. 2012 Apr 18;75(8):2404-16 - PubMed
  20. Clin Oral Investig. 2006 Sep;10(3):205-9 - PubMed
  21. Ann Otol Rhinol Laryngol. 1992 Feb;101(2 Pt 1):105-12 - PubMed
  22. Laryngoscope. 1995 Apr;105(4 Pt 1):391-6 - PubMed
  23. Cancer Res. 1996 Jun 1;56(11):2488-92 - PubMed
  24. Cancer. 1953 Sep;6(5):963-8 - PubMed

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