Iran J Child Neurol. 2015;9(1):49-55.
Comparative efficacy of zonisamide and pregabalin as an adjunctive therapy in children with refractory epilepsy.
Iranian journal of child neurology
Mohammad Mahdi Taghdiri, Mohammad Kazem Bakhshandeh Bali, Parvaneh Karimzadeh, Mohammad Reza Ashrafi, Seyed Hassan Tonekaboni, Mohammad Ghofrani
Affiliations
Affiliations
- Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; Pediatric Neurology Center of Excellence, Department of Pediatric Neurology, Mofid Children Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- Pediatric Neurology Center of Excellence, Department of Pediatric Neurology, Mofid Children Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- Pediatrics Center of Excellence, Department of Pediatric Neurology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
PMID: 25767539
PMCID: PMC4322499
Abstract
OBJECTIVE: Approximately one third of epileptic children are resistant to anticonvulsant drugs. This study evaluates the effectiveness, safety, and tolerability of pregabalin as adjunctive therapy in epileptic children relative to Zonisamide.
MATERIALS & METHODS: From April 2012 to November 2012,121 children were referred to Mofid Children's Hospital with intractable epilepsy and enrolled in the study. The patients were divided into two groups (A and B) randomly. Group A was treated with Zonisamide and group B was treated with Pregabalin in addition to prior medication. We assessed seizure frequency and severity during a 4-week interval from the beginning of the drug treatment and compared the efficacy of each in these two groups.
RESULTS: Group A consists of 61 patients, 26 (42.6%) girls, and35 (57.4%) boys with an age range from 1.5 months-14 years (mean, 73.9± 44.04 months). Group B consists of 60 patients, 31(51.7%) girls, 29 (48.3%) boys with an age range from 6 months-16 years (mean, 71±42.9 months). Age, gender, seizure onset, seizure frequency, seizure type, and previous antiepileptic medications showed that there was no significant difference between the groups (P>0.05). Zonisamide and pregabalin reduced more than 50% of seizure intensity in 40.2%; 45.8% of patients also had a seizure frequency decline between35.8-44.4%, respectively and there was no significant superiority between these two novel anticonvulsants (P>0.05).
CONCLUSION: In this survey both pregabalin and Zonisamide were impressive for seizure control in children with intractable epilepsy and well sustained with mild complications that were completely reversible.
Keywords: Antiepileptic drugs; Epileptic children; Intractable Epilepsy; Pregabalin; Zonisamide
References
- Neurology. 2003 Jun 10;60(11 Suppl 4):S2-12 - PubMed
- Pain. 2003 Sep;105(1-2):133-41 - PubMed
- Epilepsia. 2009 Mar;50(3):464-74 - PubMed
- Epilepsia. 2005 Dec;46(12):1926-36 - PubMed
- Seizure. 2010 Jan;19(1):31-5 - PubMed
- Epilepsy Res. 2007 Jul;75(2-3):75-83 - PubMed
- Epilepsy Res. 2010 May;89(2-3):163-75 - PubMed
- Seizure. 2004 Dec;13 Suppl 1:S5-9; discussion S10 - PubMed
- Epilepsy Behav. 2010 Apr;17(4):455-60 - PubMed
- Epilepsy Res. 2006 Feb;68 Suppl 2:S3-9 - PubMed
- Epilepsy Res. 2006 Feb;68 Suppl 2:S25-33 - PubMed
- Epilepsy Res. 2010 Sep;91(1):10-9 - PubMed
- Epilepsy Res. 2011 Sep;96(1-2):39-44 - PubMed
- Epilepsia. 2006 Aug;47(8):1253-84 - PubMed
- N Engl J Med. 2000 Feb 3;342(5):314-9 - PubMed
- Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17537-42 - PubMed
- Epilepsy Res. 2007 Feb;73(2):137-50 - PubMed
- Epilepsy Behav. 2008 Oct;13(3):554-6 - PubMed
- Epilepsia. 2004;45 Suppl 6:13-8 - PubMed
- Seizure. 2012 Apr;21(3):188-93 - PubMed
- Epilepsy Res. 2009 Feb;83(2-3):112-6 - PubMed
- Epilepsia. 2004 Jan;45(1):20-7 - PubMed
- Neurology. 2003 May 27;60(10):1631-7 - PubMed
- Brain Dev. 2008 Oct;30(9):549-55 - PubMed
- Neurology. 2001 Jun 12;56(11):1445-52 - PubMed
- Pol J Pharmacol. 2003 Sep-Oct;55(5):683-9 - PubMed
Publication Types