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Moura LF, Vidor SB, Trindade AB, et al. Meloxicam subaracnoide não inibe a hipernocicepção mecânica no teste da carragenina em ratos. [Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats]. Rev Bras Anestesiol. 2014;65(2):124-9doi: 10.1016/j.bjan.2013.10.018.
Moura, L. F., Vidor, S. B., Trindade, A. B., Mörschbächer, P. D., Oleskovicz, N., & Contesini, E. A. (2015). Meloxicam subaracnoide não inibe a hipernocicepção mecânica no teste da carragenina em ratos. [Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats]. Revista brasileira de anestesiologia, 65(2), 124-9. https://doi.org/10.1016/j.bjan.2013.10.018
Moura, Lanucha Fidelis da Luz, et al. "Meloxicam subaracnoide não inibe a hipernocicepção mecânica no teste da carragenina em ratos." [Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats]. Revista brasileira de anestesiologia vol. 65,2 (2015): 124-9. doi: https://doi.org/10.1016/j.bjan.2013.10.018
Moura LF, Vidor SB, Trindade AB, Mörschbächer PD, Oleskovicz N, Contesini EA. Meloxicam subaracnoide não inibe a hipernocicepção mecânica no teste da carragenina em ratos. [Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats]. Rev Bras Anestesiol. 2015 Mar-Apr;65(2):124-9. doi: 10.1016/j.bjan.2013.10.018. Epub 2014 Sep 26. Portuguese. PMID: 25740279.
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Rev Bras Anestesiol. 2015 Mar-Apr;65(2):124-9. doi: 10.1016/j.bjan.2013.10.018. Epub 2014 Sep 26.

[Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats].

Revista brasileira de anestesiologia

[Article in Portuguese]
Lanucha Fidelis da Luz Moura, Silvana Bellini Vidor, Anelise Bonilla Trindade, Priscilla Domingues Mörschbächer, Nilson Oleskovicz, Emerson Antonio Contesini

Affiliations

  1. Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil. Electronic address: [email protected].
  2. Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
  3. Universidade do Estado de Santa Catarina, Florianópolis, SC, Brasil.
  4. Faculdade de Veterinária da Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.

PMID: 25740279 DOI: 10.1016/j.bjan.2013.10.018

Abstract

BACKGROUND AND OBJECTIVE: Evaluate the antinociceptive effects of subarachnoid meloxicam on the mechanical hypernociception induced by carrageenan in rats.

METHODS: Randomized controlled trial. Eighteen adult male Wistar rats underwent a cannula implantation into the subarachnoid space and were randomly divided into two groups: Group I (GI) received saline solution 5μL, while Group II (GII) received meloxicam 30mg. The mechanical hypernociception was induced by intraplantar injection of carrageenan and evaluated using a digital analgesymeter every 30minutes during a 4 hour period. The results were recorded as the Δ withdrawal threshold (in g), calculated by subtracting the measurement value after

RESULTS: The Δ withdrawal threshold mean values were lower in the group of patients treated with meloxicam over all time points between 45 and 165minutes, however, there was no statistical significance, (p=0.835) for this difference.

CONCLUSION: Subarachnoid meloxicam at a dose of 30μg.animal(-1) did not suppress the mechanical hypernociception in a model of inflammatory pain induced by intraplantar administration of carrageenan in rats. The data suggest that other dosages should be investigated the drug effect is discarded.

Copyright © 2014 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

Keywords: AINE; Carrageenan; Carragenina; Dor; Medula espinhal; NSAIDs; Pain; Spinal cord

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