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Winkelmann RR, Nikolaidis G, Rigel DS, et al. Comparison of the Distribution of Morphological Disorganization of Pigmented Lesions in a Community-based Practice versus a University-based Clinical Setting as Measured by a Multispectral Digital Skin Lesion Analysis Device: Impact on Diagnosis. J Clin Aesthet Dermatol. 2015;8(2):16-8
Winkelmann, R. R., Nikolaidis, G., Rigel, D. S., Tucker, N., & Speck, L. (2015). Comparison of the Distribution of Morphological Disorganization of Pigmented Lesions in a Community-based Practice versus a University-based Clinical Setting as Measured by a Multispectral Digital Skin Lesion Analysis Device: Impact on Diagnosis. The Journal of clinical and aesthetic dermatology, 8(2), 16-8.
Winkelmann, Richard R, et al. "Comparison of the Distribution of Morphological Disorganization of Pigmented Lesions in a Community-based Practice versus a University-based Clinical Setting as Measured by a Multispectral Digital Skin Lesion Analysis Device: Impact on Diagnosis." The Journal of clinical and aesthetic dermatology vol. 8,2 (2015): 16-8.
Winkelmann RR, Nikolaidis G, Rigel DS, Tucker N, Speck L. Comparison of the Distribution of Morphological Disorganization of Pigmented Lesions in a Community-based Practice versus a University-based Clinical Setting as Measured by a Multispectral Digital Skin Lesion Analysis Device: Impact on Diagnosis. J Clin Aesthet Dermatol. 2015 Feb;8(2):16-8. PMID: 25741398; PMCID: PMC4345928.
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J Clin Aesthet Dermatol. 2015 Feb;8(2):16-8.

Comparison of the Distribution of Morphological Disorganization of Pigmented Lesions in a Community-based Practice versus a University-based Clinical Setting as Measured by a Multispectral Digital Skin Lesion Analysis Device: Impact on Diagnosis.

The Journal of clinical and aesthetic dermatology

Richard R Winkelmann, Gregory Nikolaidis, Darrell S Rigel, Natalie Tucker, Laura Speck

Affiliations

  1. Rigel Dermatology, New York, New York;
  2. Westlake Dermatology, Austin, Texas;
  3. Department of Dermatology, New York University School of Medicine, New York, New York;
  4. MELA Sciences Inc., Irvington, New York.

PMID: 25741398 PMCID: PMC4345928

Abstract

OBJECTIVE: To observe how a multispectral digital skin lesion analysis device was used by dermatologists in a community-based clinical setting and determine differences from a university-based environment.

DESIGN: Use of multispectral digital skin lesion analysis was incorporated into a community-based practice by 12 dermatologists across six clinics over seven consecutive days with the data provided by the device integrated as an adjuvant to their clinical evaluation for their pigmented lesion management decisions. Multispectral digital skin lesion analysis results were collected electronically for lesions prior to biopsy, and histopathological evaluation was performed for the biopsied lesions. Multispectral digital skin lesion analysis and pathology results were then compared to assess the degree of morphological disorganization.

SETTING/PARTICIPANTS: Study of 160 consecutive patients in community-based clinical setting.

MEASUREMENTS: Proportion of "low" and "high" disorganization lesions identified by multispectral digital skin lesion analysis.

RESULTS: Of the 344 pigmented skin lesions analyzed by multispectral digital skin lesion analysis, 255 were high disorganization, 113 of which were biopsied. Of the 89 lesions evaluated by multispectral digital skin lesion analysis to be low disorganization, seven were biopsied and all pathology was benign. Data demonstrate a higher rate of multispectral digital skin lesion analysis low disorganization readings for pigmented skin lesions (32% for single use per patient lesions, p<0.0001; 26% for all lesions, p<0.0001) than observed in the pigmented lesions clinics providing data for the university-based clinical study (10%).

CONCLUSION: Multispectral digital skin lesion analysis in the community-based clinical setting may outperform specificity results from the university-based clinical trial study, perhaps because of a higher proportion of subtle lesions encountered at high-risk pigmented lesion clinics of participating major academic centers as compared with those in a community-based practice setting.

References

  1. J Clin Aesthet Dermatol. 2015 Mar;8(3):20-2 - PubMed
  2. Arch Dermatol. 2011 Feb;147(2):188-94 - PubMed
  3. J Clin Aesthet Dermatol. 2014 Dec;7(12):16-8 - PubMed
  4. Melanoma Res. 2000 Dec;10(6):563-70 - PubMed
  5. Dermatol Clin. 2012 Jul;30(3):535-45 - PubMed

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