Int J High Risk Behav Addict. 2014 Sep 17;3(4):e21076. doi: 10.5812/ijhrba.21076. eCollection 2014 Dec.

The effects of ecstasy on liver function tests, blood glucose, and lipids profile of male rats.

International journal of high risk behaviors & addiction

Mohammad Reza Shahraki, Mahdieh Irani

PMID: 25741481 PMCID: PMC4331654 DOI: 10.5812/ijhrba.21076

Abstract

BACKGROUND: Ecstasy is used to improve mood and cordiality; however, based on some reports, it is neurotoxic to human users.

OBJECTIVES: Because of the euphoria induced by MDMA (3,4-methylenedioxymethamphetamine) on the users, its consumption is increasing in almost all countries. This study was carried out to determine the effects of ecstasy administration in rats' blood sugar, lipids profile, and liver function tests.

MATERIALS AND METHODS: The experiment was performed using 50 mature Wistar-Albino male rats. The rats were divided into five groups (n = 10). Sham control group (A), received tap water and ordinary rodent diet. The control (B) was administered saline but tests group C, D1, and D2 received single dose and multiple doses of MDMA, respectively. After experimental period, animals were deeply anesthetized by diethyl ether, sacrificed and the blood samples were collected for the evaluation of blood glucose, serum lipid and aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALK-P). Data were expressed as mean ± SD and statistical difference was considered significant at P < 0.05.

RESULTS: In C group, the values of blood sugar (193.8 ± 11.6 mg/dL), low density lipoprotein (LDL) (19.2 ± 7.9 mg/dL), and cholesterol (76.1 ± 10.6 mg/dL), were significantly increased compared with those of control A and B (135 ± 12.7), (140 ± 18.8), and (45.4 ± 9.8), (49.8 ± 2.1) (49.4 ± 10.6) groups. However, aspartate transaminase (AST) and alanine transaminase (ALT) were significantly increased in groups D1 (145.8 ± 14.7 U/L), (91.1 ± 8.1 U/L), and D2 (159.4 ± 13.8 U/L) and (75.4 ± 7.8) compared with those of group A (107.2 ± 8.1), (45.4 ± 9.8), B (79.8 ± 12.1), (49.8 ± 2.1), and C (115.6 ± 17.5), (52.1 ± 7.6 U/L). Cholesterol and LDL increased in groups C and D compared with group A.

CONCLUSIONS: These results indicated that chronic administration of MDMA affects liver as well as lipoprotein profile in male rats. The exact mechanism of action needs further investigation.

Keywords: Alanine Transaminase; Aspartate Aminotransferases; Blood Glucose; N-Methyl-3, 4-methylenedioxyamphetamine; Rats

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