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Karampelas M, Pefkianaki M, Rees A, et al. Missed Hospital Appointments of Patients Receiving Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration. Ophthalmol Ther. 2015;4(1):43-9doi: 10.1007/s40123-015-0031-5.
Karampelas, M., Pefkianaki, M., Rees, A., Gill, N., Kotecha, A., Hamilton, R., Nikita, E., & Patel, P. J. (2015). Missed Hospital Appointments of Patients Receiving Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration. Ophthalmology and therapy, 4(1), 43-9. https://doi.org/10.1007/s40123-015-0031-5
Karampelas, Michael, et al. "Missed Hospital Appointments of Patients Receiving Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration." Ophthalmology and therapy vol. 4,1 (2015): 43-9. doi: https://doi.org/10.1007/s40123-015-0031-5
Karampelas M, Pefkianaki M, Rees A, Gill N, Kotecha A, Hamilton R, Nikita E, Patel PJ. Missed Hospital Appointments of Patients Receiving Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration. Ophthalmol Ther. 2015 Jun;4(1):43-9. doi: 10.1007/s40123-015-0031-5. Epub 2015 Mar 14. PMID: 25769782; PMCID: PMC4470979.
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Ophthalmol Ther. 2015 Jun;4(1):43-9. doi: 10.1007/s40123-015-0031-5. Epub 2015 Mar 14.

Missed Hospital Appointments of Patients Receiving Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration.

Ophthalmology and therapy

Michael Karampelas, Maria Pefkianaki, Angela Rees, Navdeep Gill, Aachal Kotecha, Robin Hamilton, Eleni Nikita, Praveen J Patel

Affiliations

  1. NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, UK, [email protected].

PMID: 25769782 PMCID: PMC4470979 DOI: 10.1007/s40123-015-0031-5

Abstract

INTRODUCTION: The aim of this study was to investigate the frequency and duration of missed hospital appointments (MHAs) in a consecutive cohort of patients treated with ranibizumab for neovascular age-related macular degeneration (nAMD) and to assess their impact on outcomes of therapy in a real-world clinical setting.

METHODS: Retrospective, cross-sectional study of consecutive patients attending medical retina clinics for nAMD treatment with ranibizumab.

RESULTS: Seventy-eight eyes of 78 patients met the inclusion criteria for data analysis. Mean age was 78 years with mean follow-up of 27 months. Mean visual acuity (VA) was 52 ± 16 letters at baseline, 56 ± 17 letters at year 1 and 58 ± 16 letters at year 2. At the end of the second year, 90% of the patients had lost <15 letters, 26% had gained ≥15 letters and 10% had lost ≥15 letters. Nineteen patients had at least one MHA (24%) over 2 years. There were 26 MHA episodes in total leading to a median duration of 79 days (range 35-159) between attended hospital visits. None of these MHAs occurred during the first 3 months after treatment initiation. Mean VA and central retinal thickness difference between 2 years and baseline for the MHA group was not statistically different compared with the non-MHA group.

CONCLUSIONS: Our data suggest that MHA may be a relatively common occurrence in AMD treatment clinics, but good outcomes of treatment can be achieved over 2 years despite missed hospital visits if patients are reviewed on average six times in the first year after an initial loading phase of three injections and nine times in the second year of treatment.

References

  1. Ophthalmology. 2012 Jul;119(7):1399-411 - PubMed
  2. Am J Ophthalmol. 2009 Sep;148(3):409-13 - PubMed
  3. Ophthalmology. 2008 Jan;115(1):116-26 - PubMed
  4. Am J Ophthalmol. 2010 Sep;150(3):315-324.e1 - PubMed
  5. Arch Ophthalmol. 2000 Jun;118(6):819-25 - PubMed
  6. Am J Ophthalmol. 2009 Jul;148(1):43-58.e1 - PubMed
  7. Retina. 2012 Sep;32(8):1480-5 - PubMed
  8. Br J Ophthalmol. 2008 Dec;92(12):1636-41 - PubMed
  9. Ophthalmology. 2011 May;118(5):831-9 - PubMed
  10. Ophthalmology. 2009 Sep;116(9):1740-7 - PubMed
  11. Arch Ophthalmol. 2000 Feb;118(2):264-9 - PubMed
  12. Arch Ophthalmol. 2004 Apr;122(4):564-72 - PubMed
  13. BMJ. 2010 Jun 09;340:c2459 - PubMed
  14. N Engl J Med. 2011 May 19;364(20):1897-908 - PubMed
  15. Ophthalmology. 2009 Jan;116(1):57-65.e5 - PubMed
  16. N Engl J Med. 2006 Oct 5;355(14):1419-31 - PubMed
  17. Ophthalmology. 1995 Feb;102(2):205-10 - PubMed

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