Indian J Dermatol. 2015 Mar-Apr;60(2):147-52. doi: 10.4103/0019-5154.152510.
Glycolic Acid peels/azelaic Acid 20% cream combination and low potency triple combination lead to similar reduction in melasma severity in ethnic skin: results of a randomized controlled study.
Indian journal of dermatology
Rahul Mahajan, Amrinder Jit Kanwar, Davinder Parsad, Muthu Sendhil Kumaran, Reena Sharma
Affiliations
Affiliations
- Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
PMID: 25814702
PMCID: PMC4372906 DOI: 10.4103/0019-5154.152510
Abstract
BACKGROUND: Numerous therapeutic options have been tried in the management of melasma.
AIMS AND OBJECTIVES: This prospective randomized study was planned to assess the efficacy of low potency triple combination (TC) cream (TC-hydroquinone 2%/tretinoin 0.05%/fluocinolone 0.01%) versus glycolic acid (GA) peels/azelaic acid (AA) 20% cream (GA/AA) combination in melasma.
MATERIALS AND METHODS: Forty patients with melasma were recruited into this study and randomized into two groups. Group A consisting 20 patients received TC cream once a day for night time application for 3 months. Group B comprising of 20 patients received GA/AA 20% cream combination for 3 months. The disease severity was monitored with digital photography, melasma area and severity index (MASI) score, which was calculated at baseline, 6 weeks and 12 weeks, and visual analog scale (VAS) score, which was calculated at baseline and 12 weeks.
RESULTS: Of 40 patients, 38 were completed the study. A significant reduction in MASI and VAS was recorded after 6 weeks and 12 weeks of treatment in both groups A and B (P = 0.001). However, there was no significant difference in the mean MASI scores between the two groups at baseline, 6 weeks and 12 weeks. Similarly, there was no difference in the mean VAS scores between the two groups at baseline and 12 weeks. Four patients in group A and 3 in group B experienced adverse effects such as irritation, dryness, and photosensitivity.
CONCLUSION: Both low potency TC cream and GA/AA 20% cream combination are effective in treating melasma among Indian patients.
Keywords: Glycolic peels; melasma; triple combination
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