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Wong D, Carson J, Johnson A. Subacute bacterial endocarditis caused by Cardiobacterium hominis: A case report. Can J Infect Dis Med Microbiol. 2015;26(1):41-3doi: 10.1155/2015/568750.
Wong, D., Carson, J., & Johnson, A. (2015). Subacute bacterial endocarditis caused by Cardiobacterium hominis: A case report. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 26(1), 41-3. https://doi.org/10.1155/2015/568750
Wong, Davie, et al. "Subacute bacterial endocarditis caused by Cardiobacterium hominis: A case report." The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale vol. 26,1 (2015): 41-3. doi: https://doi.org/10.1155/2015/568750
Wong D, Carson J, Johnson A. Subacute bacterial endocarditis caused by Cardiobacterium hominis: A case report. Can J Infect Dis Med Microbiol. 2015 Jan-Feb;26(1):41-3. doi: 10.1155/2015/568750. PMID: 25798154; PMCID: PMC4353269.
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Can J Infect Dis Med Microbiol. 2015 Jan-Feb;26(1):41-3. doi: 10.1155/2015/568750.

Subacute bacterial endocarditis caused by Cardiobacterium hominis: A case report.

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

Davie Wong, Julie Carson, Andrew Johnson

Affiliations

  1. Internal Medicine, University of Manitoba, Winnipeg, Manitoba;
  2. Section of Microbiology, Department of Pathology and Laboratory Medicine, University of Calgary; ; Calgary Laboratory Services;
  3. Section of Infectious Diseases, Department of Medicine, University of Calgary, Calgary, Alberta.

PMID: 25798154 PMCID: PMC4353269 DOI: 10.1155/2015/568750

Abstract

Cardiobacterium hominis, a member of the HACEK group of organisms, is an uncommon but important cause of subacute bacterial endocarditis. First-line therapy is a third-generation cephalosporin due to rare beta-lactamase production. The authors report a case involving endovascular infection due to C hominis that initially tested resistant to third-generation cephalosporins using an antibiotic gradient strip susceptibility method (nitrocephin negative), but later proved to be susceptible using broth microdilution reference methods (a 'major' error). There are limited studies to guide susceptibility testing and interpretive breakpoints for C hominis in the medical literature, and the present case illustrates some of the issues that may arise when performing susceptibility testing for fastidious organisms in the clinical microbiology laboratory.

Keywords: Cardiobacterium hominis; Etest; Infective endocarditis

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