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Amizadeh M, Shamsadini A, Arabzadeh A, et al. Association of cagA Positive Helicobacter pylori Infection and Laryngeal Squamous Cell Carcinoma: A PCR Approach. Indian J Otolaryngol Head Neck Surg. 2014;67:51-5doi: 10.1007/s12070-014-0750-2.
Amizadeh, M., Shamsadini, A., Arabzadeh, A., & Jazayeri, S. (2015). Association of cagA Positive Helicobacter pylori Infection and Laryngeal Squamous Cell Carcinoma: A PCR Approach. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 6751-5. https://doi.org/10.1007/s12070-014-0750-2
Amizadeh, Maryam, et al. "Association of cagA Positive Helicobacter pylori Infection and Laryngeal Squamous Cell Carcinoma: A PCR Approach." Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India vol. 67 (2015): 51-5. doi: https://doi.org/10.1007/s12070-014-0750-2
Amizadeh M, Shamsadini A, Arabzadeh A, Jazayeri S. Association of cagA Positive Helicobacter pylori Infection and Laryngeal Squamous Cell Carcinoma: A PCR Approach. Indian J Otolaryngol Head Neck Surg. 2015 Mar;67:51-5. doi: 10.1007/s12070-014-0750-2. Epub 2014 Aug 20. PMID: 25621254; PMCID: PMC4298619.
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Indian J Otolaryngol Head Neck Surg. 2015 Mar;67:51-5. doi: 10.1007/s12070-014-0750-2. Epub 2014 Aug 20.

Association of cagA Positive Helicobacter pylori Infection and Laryngeal Squamous Cell Carcinoma: A PCR Approach.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

Maryam Amizadeh, Ayeh Shamsadini, Aliakbar Arabzadeh, Seyedbehzad Jazayeri

Affiliations

  1. Department of Otorhinolaryngology, Kerman University of Medical Sciences, Kerman, Iran.
  2. Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran.
  3. Farzan Clinical Research Institute, Tehran, Iran.

PMID: 25621254 PMCID: PMC4298619 DOI: 10.1007/s12070-014-0750-2

Abstract

Helicobacter pylori is a gram-negative bacillus causing benign and malignant gastric diseases such as gastroesophageal reflux (GER). In larynx, H. pylori causes chronic inflammation and mucosal destruction that may lead to malignant changes. Although, H. pylori poses several virulence factors, cagA is probably the main factor in this regard. To evaluate the role of cagA gene in laryngeal squamous cell carcinoma (LSCC), a case-control study was conducted on patients with laryngeal complaints during 2010-2012. Seventy-two patients with LSCC (case group) and 72 patients without malignancy (control group) were included in the study. The H. pylori and cagA factor were assessed in laryngeal specimen of patients with PCR technique. 33 % of patients in case group (24 patients) and 45.8 % (33 patients) of control group were positive for H. pylori. CagA gene was present in 13.8 % (10 patients) of case group specimens and 31.9 % (23 patients) of control group. This difference was statistically significant with Mantel-Haenszel statistical test analyses. The results showed that patients with LSCC have significantly lower incidence of laryngeal H. pylori infection and cagA virulence factor than those without LSCC. Findings from this study support the protective effect of H. pylori infection against laryngeal cancer.

Keywords: Helicobacter pylori; Laryngeal cancer; SCC; cagA

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