Display options
Cite
Yilmaz VT, Dincer D, Avci AB, et al. Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis. Eurasian J Med. 2015;47(1):21-5doi: 10.5152/eajm.2014.0016.
Yilmaz, V. T., Dincer, D., Avci, A. B., & Cetinkaya, R. (2015). Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis. The Eurasian journal of medicine, 47(1), 21-5. https://doi.org/10.5152/eajm.2014.0016
Yilmaz, Vural Taner, et al. "Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis." The Eurasian journal of medicine vol. 47,1 (2015): 21-5. doi: https://doi.org/10.5152/eajm.2014.0016
Yilmaz VT, Dincer D, Avci AB, Cetinkaya R. Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis. Eurasian J Med. 2015 Feb;47(1):21-5. doi: 10.5152/eajm.2014.0016. PMID: 25745341; PMCID: PMC4341924.
Copy Download .nbib Format: NLM
Share it on

Eurasian J Med. 2015 Feb;47(1):21-5. doi: 10.5152/eajm.2014.0016.

Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis.

The Eurasian journal of medicine

Vural Taner Yilmaz, Dinc Dincer, Ali Berkant Avci, Ramazan Cetinkaya

Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Akdeniz University Medical School, Antalya, Turkey.
  2. Division of Gastroenterology, Department of Internal Medicine, Akdeniz University Medical School, Antalya, Turkey.
  3. Division of Rheumatology, Department of Internal Medicine, Akdeniz University Medical School, Antalya, Turkey.

PMID: 25745341 PMCID: PMC4341924 DOI: 10.5152/eajm.2014.0016

Abstract

OBJECTIVE: Von Willebrand factor (vWF) is a mediator that increases endotoxemic medium like in cirrhosis. In this study we evaluated the association of serum VWF antigen (Ag) level with the stage of cirrhosis (according to Child-Pugh classification).

MATERIALS AND METHODS: We included 82 cirrhotic patients (Female/Male (F/M): 26/56) and 86 healthy subjects (F/M: 44/42) in the study. Ages of the both groups of patients were not different (P= 0.095). We excluded possible other reasons that may cause VWF level increase. Diagnosis of cirrhosis was made on the basis of biopsy in 7 patients and with clinical and laboratory parameters in 75 patients. VWF Ag level was determined by immunoturbidimetric test. The stage of cirrhosis was defined with Child-Pugh classification. Data were analysed by using Statistical Package for the Social Sciences (SPSS) 10.0 software program.

RESULTS: VWF Ag level was significantly higher in cirrhotic patients compared to control group (220±90 and 87±38, P<0.001, respectively). We observed significant increase of VWF Ag level with the increasing stages of cirrhosis according to Child-Pugh score (VWF Ag level for Child A-B-C 156.4±54/215±45/284.8±93, respectively; P values for Child A-B/A-C/B-C; <0.001/<0.001/0.006, respectively).

CONCLUSION: Serum VWF Ag level increases in cirrhotic patients and this is more pronounced with higher stages of cirrhosis.

Keywords: Child Pugh classification; Cirrhosis; von Willebrand factor

References

  1. Eur J Gastroenterol Hepatol. 1999 Jul;11(7):755-9 - PubMed
  2. Hepatology. 1986 Sep-Oct;6(5):1036-7 - PubMed
  3. Scand J Gastroenterol. 1989 Apr;24(3):269-76 - PubMed
  4. J Hepatol. 2001 Jan;34(1):32-7 - PubMed
  5. J Clin Invest. 1986 Dec;78(6):1456-61 - PubMed
  6. Haematologica. 2001 Nov;86(11):1180-5 - PubMed
  7. J Hepatol. 1998 Feb;28(2):307-13 - PubMed
  8. Am J Med. 1997 Dec;103(6):536-40 - PubMed
  9. Hepatology. 1994 Nov;20(5):1343-50 - PubMed
  10. J Hepatol. 1999 Mar;30(3):451-5 - PubMed
  11. Hepatology. 1996 Jun;23(6):1377-83 - PubMed
  12. Hepatology. 2012 Oct;56(4):1439-47 - PubMed
  13. Hepatology. 1988 Mar-Apr;8(2):232-6 - PubMed
  14. Blood. 1995 Jun 1;85(11):3164-72 - PubMed
  15. Gut. 2011 Aug;60(8):1133-8 - PubMed
  16. Lancet. 1991 Mar 30;337(8744):776-8 - PubMed

Publication Types