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Eurasian J Med. 2015 Feb;47(1):62-5. doi: 10.5152/eajm.2014.57. Epub 2014 Dec 05.

Growth hormone therapy in children with chronic renal failure.

The Eurasian journal of medicine

Atilla Cayir, Celalettin Kosan

Affiliations

  1. Department of Pediatric Endocrinology, Regional Training and Research Hospital, Erzurum, Turkey.
  2. Department of Pediatric Nephrology, Ataturk University Faculty of Medicine, Erzurum, Turkey.

PMID: 25745347 PMCID: PMC4341930 DOI: 10.5152/eajm.2014.57

Abstract

Growth is impaired in a chronic renal failure. Anemia, acidosis, reduced intake of calories and protein, decreased synthesis of vitamin D and increased parathyroid hormone levels, hyperphosphatemia, renal osteodystrophy and changes in growth hormone-insulin-like growth factor and the gonadotropin-gonadal axis are implicated in this study. Growth is adversely affected by immunosuppressives and corticosteroids after kidney transplantation. Treating metabolic disorders using the recombinant human growth hormone is an effective option for patients with inadequate growth rates.

Keywords: Child; chronic renal failure; growth hormone; therapy

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