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Nogami T, Taira N, Toyooka S, et al. A case of carcinoma showing thymus-like differentiation with a rapidly lethal course. Case Rep Oncol. 2014;7(3):840-4doi: 10.1159/000370306.
Nogami, T., Taira, N., Toyooka, S., Tanaka, T., Mizoo, T., Iwamoto, T., Shien, T., Soh, J., Miyoshi, S., & Doihara, H. (2014). A case of carcinoma showing thymus-like differentiation with a rapidly lethal course. Case reports in oncology, 7(3), 840-4. https://doi.org/10.1159/000370306
Nogami, Tomohiro, et al. "A case of carcinoma showing thymus-like differentiation with a rapidly lethal course." Case reports in oncology vol. 7,3 (2014): 840-4. doi: https://doi.org/10.1159/000370306
Nogami T, Taira N, Toyooka S, Tanaka T, Mizoo T, Iwamoto T, Shien T, Soh J, Miyoshi S, Doihara H. A case of carcinoma showing thymus-like differentiation with a rapidly lethal course. Case Rep Oncol. 2014 Dec 20;7(3):840-4. doi: 10.1159/000370306. eCollection 2014. PMID: 25685135; PMCID: PMC4307009.
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Case Rep Oncol. 2014 Dec 20;7(3):840-4. doi: 10.1159/000370306. eCollection 2014.

A case of carcinoma showing thymus-like differentiation with a rapidly lethal course.

Case reports in oncology

Tomohiro Nogami, Naruto Taira, Shinichi Toyooka, Takehiro Tanaka, Taeko Mizoo, Takayuki Iwamoto, Tadahiko Shien, Junichi Soh, Shinichiro Miyoshi, Hiroyoshi Doihara

Affiliations

  1. Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
  2. Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan.
  3. Department of Pathology, Okayama University Hospital, Okayama, Japan.

PMID: 25685135 PMCID: PMC4307009 DOI: 10.1159/000370306

Abstract

A 55-year-old woman underwent a total thyroidectomy for carcinoma showing thymus-like differentiation (CASTLE). The patient was referred to our hospital after the tumor was found to have directly invaded the cervical esophagus and the entire circumference of the trachea. A total thyroidectomy was performed, followed by end-to-end anastomosis of the trachea, suprahyoid release and dissection of bilateral pulmonary ligaments. No major complications, including anastomotic dehiscence or stenosis, were observed. The patient experienced some swallowing disturbances and hoarseness during the perioperative period but fully recovered. Radiotherapy to the neck was performed as an adjuvant therapy. Eleven months after surgery, lower back pain and right leg numbness developed and led to gait inability. Multiple lung and bone recurrences were observed, but no local recurrence. Palliative radiotherapy to the bone metastasis was performed. The patient died of pleural metastasis 14 months after the initial diagnosis of CASTLE.

Keywords: Carcinoma showing thymus-like differentiation; Infiltrating trachea; Reconstruction

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