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Speed JS, D'Angelo G, Wach PA, et al. High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats. Physiol Rep. 2015;3(3)doi: 10.14814/phy2.12326.
Speed, J. S., D'Angelo, G., Wach, P. A., Sullivan, J. C., Pollock, J. S., & Pollock, D. M. (2015). High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats. Physiological reports, 3(3), . https://doi.org/10.14814/phy2.12326
Speed, Joshua S, et al. "High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats." Physiological reports vol. 3,3 (2015). doi: https://doi.org/10.14814/phy2.12326
Speed JS, D'Angelo G, Wach PA, Sullivan JC, Pollock JS, Pollock DM. High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats. Physiol Rep. 2015 Mar;3(3). doi: 10.14814/phy2.12326. Epub 2015 Mar 22. PMID: 25802361; PMCID: PMC4393160.
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Physiol Rep. 2015 Mar;3(3). doi: 10.14814/phy2.12326. Epub 2015 Mar 22.

High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats.

Physiological reports

Joshua S Speed, Gerard D'Angelo, Paul A Wach, Jennifer C Sullivan, Jennifer S Pollock, David M Pollock

Affiliations

  1. Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  2. Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA [email protected].

PMID: 25802361 PMCID: PMC4393160 DOI: 10.14814/phy2.12326

Abstract

Acute stress in both rodents and humans causes a transient rise in blood pressure associated with an increase in plasma endothelin-1 (ET-1). High salt (HS) intake also increases ET-1 production, and interestingly, blunts the pressor response to acute air jet stress in rats. We previously reported that female rats lacking functional ETB receptors everywhere except sympathetic nerves (ETB def) had a greater degree of hypertension in response to a HS diet compared to their male counterparts when measured by the tail cuff method. However, we now report that salt-induced hypertension is not different between sexes when measured by telemetry. Therefore, additional experiments were designed to test the hypothesis that female ETB def rats are more sensitive to acute stress when on a HS diet. The pressor response, measured by telemetry, to acute air jet stress was similar between male transgenic control (Tg control) and ETB def rats following chronic HS intake. In contrast, female ETB def rats had a significantly greater pressor response (about twofold higher) than female or male Tg control or male ETB def rats maintained on HS, a finding that cannot be explained by increased vascular reactivity to ET-1 in female rats as we observed that male ETB def rats had a greater pressor response to i.v. infusion of ET-1 compared to females. Furthermore, HS feeding exacerbated the pressor response to ET-1 in both male and female ETB def rats. Given our previous studies demonstrating that the ETA receptor functions to reduce the pressor response to acute stress, these findings further support a role for the ET receptor system in the pressor response to acute stress and that female rats have reduced ETA receptor activity when on a HS diet compared to males.

© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Keywords: Blood pressure; Endothelin‐1; Stress

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