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Fjeldstad C, Fjeldstad AS, Weir JP, et al. Association of vitamin D deficiency with RNFL thickness in MS individuals without history of optic neuritis. Mult Scler Relat Disord. 2014;3(4):489-93doi: 10.1016/j.msard.2014.03.001.
Fjeldstad, C., Fjeldstad, A. S., Weir, J. P., & Pardo, G. (2014). Association of vitamin D deficiency with RNFL thickness in MS individuals without history of optic neuritis. Multiple sclerosis and related disorders, 3(4), 489-93. https://doi.org/10.1016/j.msard.2014.03.001
Fjeldstad, Cecilie, et al. "Association of vitamin D deficiency with RNFL thickness in MS individuals without history of optic neuritis." Multiple sclerosis and related disorders vol. 3,4 (2014): 489-93. doi: https://doi.org/10.1016/j.msard.2014.03.001
Fjeldstad C, Fjeldstad AS, Weir JP, Pardo G. Association of vitamin D deficiency with RNFL thickness in MS individuals without history of optic neuritis. Mult Scler Relat Disord. 2014 Jul;3(4):489-93. doi: 10.1016/j.msard.2014.03.001. Epub 2014 Mar 25. PMID: 25877061.
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Mult Scler Relat Disord. 2014 Jul;3(4):489-93. doi: 10.1016/j.msard.2014.03.001. Epub 2014 Mar 25.

Association of vitamin D deficiency with RNFL thickness in MS individuals without history of optic neuritis.

Multiple sclerosis and related disorders

Cecilie Fjeldstad, Anette S Fjeldstad, Joseph P Weir, Gabriel Pardo

Affiliations

  1. OMRF Multiple Sclerosis Center of Excellence, 820 NE 15th Street, Oklahoma City, OK 73104, USA. Electronic address: [email protected].
  2. Department of Neurology, University of Utah, Imaging & Neurosciences Center at Research Park, 729 Arapeen Drive Rm 1172, Salt Lake City, UT 84108, USA. Electronic address: [email protected].
  3. Department of Health, Sport, and Exercise Sciences, 1301 Sunnyside Avenue, Robinson center 104D, University of Kansas, Lawrence, KS 66045, USA. Electronic address: [email protected].
  4. OMRF Multiple Sclerosis Center of Excellence, 820 NE 15th Street, Oklahoma City, OK 73104, USA.

PMID: 25877061 DOI: 10.1016/j.msard.2014.03.001

Abstract

UNLABELLED: Vitamin D deficiency has been associated with both increased risk and severity of Multiple Sclerosis (MS) as it has a modulating effect on the immune process that causes inflammation/demyelination and axonal damage. Optical Coherence Tomography (OCT) offers a quick, reliable and non-invasive way to assess the Retinal Nerve Fiber Layer (RNFL) and identifies axonal loss generated by either direct inflammation or from neurodegeneration.

OBJECTIVE: To determine the association of vitamin D and RNFL in MS patients without a history of Optic Neuritis (ON) by comparing RNFL thickness in patients that are vitamin D deficient with those having normal serum levels.

METHOD: The cohort of 76 MS patients underwent OCT testing to assess the RNFL thickness and macular volume, and measurement of serum 25-OH Vitamin D level. Vitamin D deficiency was defined as <30ng/ml and sufficiency as ≥30ng/ml.

RESULTS: A total of 131 eyes were divided in two groups: vitamin D deficient (n=86 eyes, mean=17.7ng/ml) and vitamin D sufficient (n=45 eyes, mean=40.3ng/ml). Twenty one eyes had previous ON and were excluded from this analysis. Vitamin D deficiency was identified in 66% of the participants. RNFL thickness was similar for the vitamin D deficient and sufficient groups (85.5 vs 86μm respectively, p=0.89). Significant differences were present for age with the deficient group being younger (42 years vs 51 years, p=0.005) and having shorter disease duration (7.5 years vs 11.4 years, p=0.006).

CONCLUSION: Vitamin D deficiency is not associated with thinning of RNFL or macular volume in MS eyes unaffected by ON. This finding suggests the role of vitamin D in modulating the severity of MS is not exerted through an influence on neurodegeneration.

Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

Keywords: Multiple sclerosis; Optic neuritis; Optical coherence tomography; Retinal nerve fiber layer; Vitamin D

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