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Clin Kidney J. 2015 Apr;8(2):191-8. doi: 10.1093/ckj/sfv003. Epub 2015 Feb 16.

Optimization of the convection volume in online post-dilution haemodiafiltration: practical and technical issues.

Clinical kidney journal

Isabelle Chapdelaine, Camiel L M de Roij van Zuijdewijn, Ira M Mostovaya, Renée Lévesque, Andrew Davenport, Peter J Blankestijn, Christoph Wanner, Menso J Nubé, Muriel P C Grooteman, P J Blankestijn, A Davenport, C Basile, F Locatelli, F Maduell, S Mitra, C Ronco, R Shroff, J Tattersall, C Wanner

Affiliations

  1. Department of Nephrology , VU University Medical Center , Amsterdam , The Netherlands.
  2. Department of Nephrology , University Medical Center Utrecht , Utrecht , The Netherlands.
  3. Department of Nephrology , Centre Hospitalier de l'Université de Montréal, St. Luc Hospital , Montréal , Canada.
  4. UCL Centre for Nephrology , Royal Free Hospital , London , UK.
  5. Division of Nephrology, Department of Medicine , University of Würzburg , Würzburg , Germany.
  6. Department of Nephrology , VU University Medical Center , Amsterdam , The Netherlands ; Institute for Cardiovascular Research VU University Medical Center (ICaR-VU), VU University Medical Center , Amsterdam , The Netherlands.

PMID: 25815176 PMCID: PMC4370303 DOI: 10.1093/ckj/sfv003

Abstract

In post-dilution online haemodiafiltration (ol-HDF), a relationship has been demonstrated between the magnitude of the convection volume and survival. However, to achieve high convection volumes (>22 L per session) detailed notion of its determining factors is highly desirable. This manuscript summarizes practical problems and pitfalls that were encountered during the quest for high convection volumes. Specifically, it addresses issues such as type of vascular access, needles, blood flow rate, recirculation, filtration fraction, anticoagulation and dialysers. Finally, five of the main HDF systems in Europe are briefly described as far as HDF prescription and optimization of the convection volume is concerned.

Keywords: convection volume; haemodiafiltration

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