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Castro-Villabón D, Barrera-Herrera LE, Rodríguez-Urrego PA, et al. Hepatocellular carcinoma with both fibrolamellar and classical components: an unusual morphological pattern. Case Rep Pathol. 2015;2015:609780doi: 10.1155/2015/609780.
Castro-Villabón, D., Barrera-Herrera, L. E., Rodríguez-Urrego, P. A., Hudacko, R., Vera, A., Álvarez, J., Andrade, R., & López, R. (2015). Hepatocellular carcinoma with both fibrolamellar and classical components: an unusual morphological pattern. Case reports in pathology, 2015609780. https://doi.org/10.1155/2015/609780
Castro-Villabón, Diana, et al. "Hepatocellular carcinoma with both fibrolamellar and classical components: an unusual morphological pattern." Case reports in pathology vol. 2015 (2015): 609780. doi: https://doi.org/10.1155/2015/609780
Castro-Villabón D, Barrera-Herrera LE, Rodríguez-Urrego PA, Hudacko R, Vera A, Álvarez J, Andrade R, López R. Hepatocellular carcinoma with both fibrolamellar and classical components: an unusual morphological pattern. Case Rep Pathol. 2015;2015:609780. doi: 10.1155/2015/609780. Epub 2015 Feb 26. PMID: 25815229; PMCID: PMC4357041.
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Case Rep Pathol. 2015;2015:609780. doi: 10.1155/2015/609780. Epub 2015 Feb 26.

Hepatocellular carcinoma with both fibrolamellar and classical components: an unusual morphological pattern.

Case reports in pathology

Diana Castro-Villabón, Luis E Barrera-Herrera, Paula A Rodríguez-Urrego, Rachel Hudacko, Alonso Vera, Johanna Álvarez, Rafael Andrade, Rocío López

Affiliations

  1. Department of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7-75, Bogotá 110111, Colombia.
  2. Department of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7-75, Bogotá 110111, Colombia ; School of Medicine, University of Los Andes, Carrera 1 No. 18A-12, Bogotá 111711, Colombia.
  3. Department of Pathology, Good Samaritan Regional Medical Center, 255 Lafayette Avenue, Suffern, NY 10901, USA.
  4. Transplant and Hepatobiliary Surgical Service, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7-75, Bogotá 110111, Colombia.
  5. Department of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Calle 119 No. 7-75, Bogotá 110111, Colombia ; School of Medicine, University of Los Andes, Carrera 1 No. 18A-12, Bogotá 111711, Colombia ; School of Medicine, National University of Colombia, Carrera 45 No. 26-85, Bogotá 111711, Colombia.

PMID: 25815229 PMCID: PMC4357041 DOI: 10.1155/2015/609780

Abstract

Fibrolamellar carcinoma (FLC) is an uncommon form of primary liver malignancy with unique clinical, histological, and biological characteristics. It is usually seen in young adults without underlying liver disease. Histologically, it shows large cells with abundant eosinophilic cytoplasm, large vesicular nuclei, prominent nucleoli, and lamellar type fibrosis. In contrast, classical hepatocellular carcinoma (HCC) is typically present in elderly male patients with cirrhosis. It is the most common histological subtype, and it is characterized by its resemblance to the normal liver, both in its growth pattern and its cytology. The unusual case of a liver carcinoma that presented with histological features of both FLC and classical HCC is herein reported. This was the case of a 37-year-old female complaining of diffuse abdominal discomfort and epigastric pain for two months. She was referred to us for further management after she was diagnosed with HCC in a noncirrhotic liver. She underwent a left-sided hepatectomy. A yellow nodular mass with well-defined borders and a necrotic center was present in the resection specimen. The morphological features and immunohistochemical studies were consistent with a diagnosis of FLC mixed with classical HCC. The patient was followed up for five months, and no signs of recurrence were evident.

References

  1. Case Reports Hepatol. 2013;2013:101862 - PubMed
  2. Science. 2014 Feb 28;343(6174):1010-4 - PubMed
  3. Am J Gastroenterol. 1998 Jul;93(7):1144-5 - PubMed
  4. Cancer. 1980 Jul 15;46(2):372-9 - PubMed
  5. Pathol Oncol Res. 2013 Jan;19(1):63-70 - PubMed
  6. Histopathology. 2006 Aug;49(2):138-51 - PubMed
  7. Surg Today. 1993;23(7):626-31 - PubMed
  8. Virchows Arch. 2011 Jun;458(6):679-88 - PubMed
  9. Hum Pathol. 2002 Jul;33(7):765-9 - PubMed
  10. Recent Results Cancer Res. 2013;190:21-32 - PubMed
  11. J Clin Gastroenterol. 2013 Jul;47 Suppl:S20-6 - PubMed
  12. J Nucl Med. 1994 Aug;35(8):1342-6 - PubMed
  13. Scientifica (Cairo). 2012;2012:743790 - PubMed
  14. Cancer Res. 2006 Sep 15;66(18):8971-4 - PubMed
  15. AMA J Dis Child. 1956 Feb;91(2):168-86 - PubMed
  16. Mod Pathol. 2011 Mar;24(3):390-5 - PubMed

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