Display options
Share it on

World J Hepatol. 2015 Mar 27;7(3):406-24. doi: 10.4254/wjh.v7.i3.406.

Staging systems for hepatocellular carcinoma: Current status and future perspectives.

World journal of hepatology

Akiyoshi Kinoshita, Hiroshi Onoda, Nao Fushiya, Kazuhiko Koike, Hirokazu Nishino, Hisao Tajiri

Affiliations

  1. Akiyoshi Kinoshita, Hiroshi Onoda, Nao Fushiya, Kazuhiko Koike, Hirokazu Nishino, Division of Gastroenterology and Hepatology, the Jikei University Daisan Hospital, Tokyo 201-8601, Japan.

PMID: 25848467 PMCID: PMC4381166 DOI: 10.4254/wjh.v7.i3.406

Abstract

Hepatocellular carcinoma (HCC) is a major health concern worldwide and the third cause of cancer-related death. Despite advances in treatment as well as careful surveillance programs, the mortality rates in most countries are very high. In contrast to other cancers, the prognosis and treatment of HCC depend on the tumor burden in addition to patient's underlying liver disease and liver functional reserve. Moreover, there is considerable geographic and institutional variation in both risk factors attributable to the underlying liver diseases and the management of HCC. Therefore, although many staging and/or scoring systems have been proposed, there is currently no globally accepted system for HCC due to the extreme heterogeneity of the disease. The aim of this review is to focus on currently available staging systems as well as those newly reported in the literatures since 2012. Moreover, we describe problems with currently available staging systems and attempts to modify and/or add variables to existing staging systems.

Keywords: Hepatocellular carcinoma; Prognosis; Scoring system; Staging system

References

  1. Gut. 2014 May;63(5):844-55 - PubMed
  2. Oncology. 2014;86(2):63-71 - PubMed
  3. Hepatology. 2004 Dec;40(6):1396-405 - PubMed
  4. Hepatology. 2011 Mar;53(3):1020-2 - PubMed
  5. Gastroenterology. 2014 Jun;146(7):1599-602 - PubMed
  6. World J Surg. 2012 Aug;36(8):1824-31 - PubMed
  7. Gut. 2002 Jun;50(6):881-5 - PubMed
  8. J Clin Oncol. 2011 Oct 10;29(29):3892-9 - PubMed
  9. Lancet. 2012 Mar 31;379(9822):1245-55 - PubMed
  10. Hepatology. 1999 Jan;29(1):62-7 - PubMed
  11. Semin Liver Dis. 1999;19(3):329-38 - PubMed
  12. J Hepatol. 1999 Jul;31(1):133-41 - PubMed
  13. Liver Int. 2006 Aug;26(6):673-9 - PubMed
  14. Intervirology. 2008;51 Suppl 1:86-94 - PubMed
  15. Liver Int. 2009 Jan;29(1):74-81 - PubMed
  16. Gastroenterology. 1996 Oct;111(4):1018-22 - PubMed
  17. Liver Int. 2012 Aug;32(7):1120-7 - PubMed
  18. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1528-36 - PubMed
  19. Aliment Pharmacol Ther. 2008 Jul;28(1):62-75 - PubMed
  20. J Clin Oncol. 2003 Feb 1;21(3):441-6 - PubMed
  21. World J Gastroenterol. 2014 Apr 21;20(15):4141-50 - PubMed
  22. J Hepatol. 2004 Jan;40(1):124-31 - PubMed
  23. J Hepatobiliary Pancreat Sci. 2011 Jan;18(1):74-80 - PubMed
  24. J Vasc Interv Radiol. 2014 Jul;25(7):1056-66 - PubMed
  25. J Am Coll Surg. 2008 Feb;206(2):281-91 - PubMed
  26. Eur J Surg Oncol. 2010 Aug;36(8):718-24 - PubMed
  27. Semin Liver Dis. 2012 Nov;32(4):348-59 - PubMed
  28. J Gastroenterol. 2003;38(3):207-15 - PubMed
  29. Am J Gastroenterol. 2005 Aug;100(8):1764-71 - PubMed
  30. J Hepatol. 2010 Jul;53(1):108-17 - PubMed
  31. J Gastroenterol Hepatol. 2008 Mar;23(3):445-52 - PubMed
  32. Ann Oncol. 2008 Jun;19(6):1117-26 - PubMed
  33. Tumori. 2007 May-Jun;93(3):264-8 - PubMed
  34. Aliment Pharmacol Ther. 2012 Sep;36(6):551-9 - PubMed
  35. Gut. 2005 Mar;54(3):411-8 - PubMed
  36. Br J Cancer. 2012 Nov 6;107(10):1672-7 - PubMed
  37. Eur J Surg Oncol. 2007 May;33(4):480-7 - PubMed
  38. Surg Oncol Clin N Am. 2014 Apr;23(2):313-22 - PubMed
  39. Hepatology. 2000 Sep;32(3):679-80 - PubMed
  40. Asia Pac J Clin Oncol. 2013 Mar;9(1):86-92 - PubMed
  41. Eur J Surg Oncol. 2005 Oct;31(8):882-90 - PubMed
  42. Liver Int. 2014 Aug;34(7):e317-23 - PubMed
  43. Hepatology. 2012 Jun;55(6):1809-19 - PubMed
  44. Oncology. 2008;75 Suppl 1:83-90 - PubMed
  45. Clin Liver Dis. 2011 May;15(2):323-34, vii-x - PubMed
  46. Liver Int. 2015 Jan;35(1):223-31 - PubMed
  47. Cancer. 2010 Jun 15;116(12):3006-14 - PubMed
  48. Lancet Oncol. 2011 Jul;12(7):654-62 - PubMed
  49. Transplant Proc. 2009 May;41(4):1260-3 - PubMed
  50. J Clin Oncol. 2002 Mar 15;20(6):1527-36 - PubMed
  51. J Hepatol. 2011 Jan;54(1):108-14 - PubMed
  52. Eur J Cancer. 2008 May;44(7):1000-6 - PubMed
  53. Med Oncol. 2012 Dec;29(4):2800-8 - PubMed
  54. J Clin Oncol. 2010 Jun 10;28(17):2889-95 - PubMed
  55. Liver Transpl. 2011 Oct;17 Suppl 2:S26-33 - PubMed
  56. PLoS One. 2014 Mar 07;9(3):e88182 - PubMed
  57. Ann Oncol. 2013 Apr;24 Suppl 2:ii24-9 - PubMed
  58. Eur J Surg Oncol. 2013 Aug;39(8):850-7 - PubMed
  59. Hepatology. 2012 Aug;56(2):614-21 - PubMed
  60. J Cancer Res Clin Oncol. 2010 Jun;136(6):821-7 - PubMed
  61. Oncology. 2011;80(5-6):373-81 - PubMed
  62. J Cancer Res Clin Oncol. 2013 Oct;139(10):1709-19 - PubMed
  63. J Gastroenterol Hepatol. 2004 Jul;19(7):805-11 - PubMed
  64. Am J Gastroenterol. 2008 Mar;103(3):597-604 - PubMed
  65. Gut. 2005 Mar;54(3):419-25 - PubMed
  66. Lancet. 2003 Dec 6;362(9399):1907-17 - PubMed
  67. Am Surg. 2013 Jul;79(7):716-22 - PubMed
  68. J Gastroenterol Hepatol. 2015 Feb;30(2):358-63 - PubMed
  69. Oncology. 2014;86(5-6):308-17 - PubMed
  70. Hepatology. 1998 Jun;27(6):1572-7 - PubMed
  71. Cancer. 2008 Jan 15;112(2):352-61 - PubMed
  72. Am J Gastroenterol. 2007 Sep;102(9):1920-30 - PubMed
  73. Hepatology. 2013 Jan;57(1):112-9 - PubMed
  74. Hepatogastroenterology. 2007 Jul-Aug;54(77):1534-8 - PubMed
  75. Hepatology. 1984 Jan-Feb;4(1 Suppl):3S-6S - PubMed
  76. Cancer. 2011 Jun 1;117(11):2478-88 - PubMed
  77. J Clin Gastroenterol. 2009 Sep;43(8):773-81 - PubMed
  78. J Hepatol. 2013 Mar;58(3):509-21 - PubMed
  79. Hepatology. 2001 Sep;34(3):529-34 - PubMed
  80. J Gastroenterol Hepatol. 2011 Feb;26(2):340-7 - PubMed
  81. PLoS One. 2014 Mar 06;9(3):e90929 - PubMed
  82. PLoS One. 2012;7(10):e45066 - PubMed
  83. Tumour Biol. 2013 Apr;34(2):1061-70 - PubMed
  84. Hepatogastroenterology. 2013 Jul-Aug;60(125):1142-7 - PubMed
  85. Hepatogastroenterology. 2009 Jul-Aug;56(93):1137-40 - PubMed
  86. Lancet Oncol. 2009 Jan;10(1):35-43 - PubMed
  87. HPB (Oxford). 2013 Jun;15(6):439-48 - PubMed
  88. Cancer. 2008 Nov 15;113(10):2742-51 - PubMed
  89. Dig Dis Sci. 2013 Sep;58(9):2721-8 - PubMed
  90. Eur J Cancer. 2011 Nov;47(17):2568-75 - PubMed
  91. Hepatology. 1998 Sep;28(3):751-5 - PubMed
  92. Liver Int. 2005 Apr;25(2):236-41 - PubMed
  93. Oncologist. 2010;15 Suppl 4:23-33 - PubMed
  94. Hepatology. 2000 Apr;31(4):840-5 - PubMed
  95. J Hepatol. 2006 Apr;44(4):723-31 - PubMed
  96. Cancer. 2002 Mar 15;94(6):1760-9 - PubMed
  97. Cancer. 1985 Aug 15;56(4):918-28 - PubMed
  98. Gastroenterology. 2013 Jul;145(1):176-87 - PubMed
  99. Eur J Cancer. 2009 Jun;45(9):1630-9 - PubMed
  100. J Natl Cancer Inst. 2008 May 21;100(10):698-711 - PubMed
  101. J Hepatol. 2012 Apr;56(4):908-43 - PubMed
  102. J Gastroenterol Hepatol. 2014 Apr;29(4):787-93 - PubMed
  103. J Cancer Res Clin Oncol. 2011 May;137(5):739-50 - PubMed
  104. Gastroenterology. 2014 Jun;146(7):1691-700.e3 - PubMed
  105. Hepatology. 2005 Apr;41(4):707-16 - PubMed
  106. Ann Oncol. 2013 Oct;24(10):2565-70 - PubMed
  107. Chin Clin Oncol. 2013 Dec;2(4):33 - PubMed

Publication Types