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Hori T, Kuribayashi K, Saito K, et al. Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity. World J Transplant. 2015;5(1):11-8doi: 10.5500/wjt.v5.i1.11.
Hori, T., Kuribayashi, K., Saito, K., Wang, L., Torii, M., Uemoto, S., Iida, T., Yagi, S., & Kato, T. (2015). Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity. World journal of transplantation, 5(1), 11-8. https://doi.org/10.5500/wjt.v5.i1.11
Hori, Tomohide, et al. "Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity." World journal of transplantation vol. 5,1 (2015): 11-8. doi: https://doi.org/10.5500/wjt.v5.i1.11
Hori T, Kuribayashi K, Saito K, Wang L, Torii M, Uemoto S, Iida T, Yagi S, Kato T. Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity. World J Transplant. 2015 Mar 24;5(1):11-8. doi: 10.5500/wjt.v5.i1.11. PMID: 25815267; PMCID: PMC4371157.
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World J Transplant. 2015 Mar 24;5(1):11-8. doi: 10.5500/wjt.v5.i1.11.

Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity.

World journal of transplantation

Tomohide Hori, Kagemasa Kuribayashi, Kanako Saito, Linan Wang, Mie Torii, Shinji Uemoto, Taku Iida, Shintaro Yagi, Takuma Kato

Affiliations

  1. Tomohide Hori, Shinji Uemoto, Taku Iida, Shintaro Yagi, Department of Hepato-Pancreato-Biliary and Transplant Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

PMID: 25815267 PMCID: PMC4371157 DOI: 10.5500/wjt.v5.i1.11

Abstract

After the first observation of the immunosuppressive effects of ultraviolet (UV) irradiation was reported in 1974, therapeutic modification of immune responses by UV irradiation began to be investigated in the context immunization. UV-induced immunosuppression is via the action of regulatory T cells (Tregs). Antigen-specific Tregs were induced by high-dose UV-B irradiation before antigen immunization in many studies, as it was considered that functional alteration and/or modulation of antigen-presenting cells by UV irradiation was required for the induction of antigen-specific immunosuppression. However, it is also reported that UV irradiation after immunization induces antigen-specific Tregs. UV-induced Tregs are also dominantly transferable, with interleukin-10 being important for UV-induced immunosuppression. Currently, various possible mechanisms involving Treg phenotype and cytokine profile have been suggested. UV irradiation accompanied by alloantigen immunization induces alloantigen-specific transferable Tregs, which have potential therapeutic applications in the transplantation field. Here we review the current status of UV-induced antigen-specific immunosuppression on the 40(th) anniversary of its discovery.

Keywords: Alloantigen; Donor-specific immunosuppression; Interleukin-10; Regulatory T cells; Ultraviolet irradiation

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