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Yano Y, Azuma T, Hayashi Y. Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics. World J Hepatol. 2015;7(3):583-92doi: 10.4254/wjh.v7.i3.583.
Yano, Y., Azuma, T., & Hayashi, Y. (2015). Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics. World journal of hepatology, 7(3), 583-92. https://doi.org/10.4254/wjh.v7.i3.583
Yano, Yoshihiko, et al. "Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics." World journal of hepatology vol. 7,3 (2015): 583-92. doi: https://doi.org/10.4254/wjh.v7.i3.583
Yano Y, Azuma T, Hayashi Y. Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics. World J Hepatol. 2015 Mar 27;7(3):583-92. doi: 10.4254/wjh.v7.i3.583. PMID: 25848482; PMCID: PMC4381181.
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World J Hepatol. 2015 Mar 27;7(3):583-92. doi: 10.4254/wjh.v7.i3.583.

Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics.

World journal of hepatology

Yoshihiko Yano, Takeshi Azuma, Yoshitake Hayashi

Affiliations

  1. Yoshihiko Yano, Takeshi Azuma, Department of Gastroenterology, Kobe University Graduate School of Medicine, Kusunoki-cho, Kobe 650-0017, Japan.

PMID: 25848482 PMCID: PMC4381181 DOI: 10.4254/wjh.v7.i3.583

Abstract

Hepatitis B virus (HBV) infection is major global issue, because chronic HBV infection is strongly associated with liver cancer. HBV spread worldwide with various mutations and variations. This variability, called quasispecies, is derived from no proof-reading capacity of viral reverse transcriptase. So far, thousands of studies reported that the variety of genome is closely related to the geographic distribution and clinical characteristics. Recent technological advances including capillary sequencer and next generation sequencer have made in easier to analyze mutations. The variety of HBV genome is related to not only antigenicity of HBs-antigen but also resistance to antiviral therapies. Understanding of these variations is important for the development of diagnostic tools and the appropriate therapy for chronic hepatitis B. In this review, recent publications in relation to HBV mutations and variations are updated and summarized.

Keywords: Hepatitis B virus; Mutation; Quasispecies

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