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Fawwad A, Siddiqui IA, Zeeshan NF, et al. Association of SNP rs9939609 in FTO gene with metabolic syndrome in type 2 diabetic subjects, rectruited from a tertiary care unit of Karachi, Pakistan. Pak J Med Sci. 2015;31(1):140-5doi: 10.12669/pjms.311.6524.
Fawwad, A., Siddiqui, I. A., Zeeshan, N. F., Shahid, S. M., & Basit, A. (2015). Association of SNP rs9939609 in FTO gene with metabolic syndrome in type 2 diabetic subjects, rectruited from a tertiary care unit of Karachi, Pakistan. Pakistan journal of medical sciences, 31(1), 140-5. https://doi.org/10.12669/pjms.311.6524
Fawwad, Asher, et al. "Association of SNP rs9939609 in FTO gene with metabolic syndrome in type 2 diabetic subjects, rectruited from a tertiary care unit of Karachi, Pakistan." Pakistan journal of medical sciences vol. 31,1 (2015): 140-5. doi: https://doi.org/10.12669/pjms.311.6524
Fawwad A, Siddiqui IA, Zeeshan NF, Shahid SM, Basit A. Association of SNP rs9939609 in FTO gene with metabolic syndrome in type 2 diabetic subjects, rectruited from a tertiary care unit of Karachi, Pakistan. Pak J Med Sci. 2015 Jan-Feb;31(1):140-5. doi: 10.12669/pjms.311.6524. PMID: 25878631; PMCID: PMC4386174.
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Pak J Med Sci. 2015 Jan-Feb;31(1):140-5. doi: 10.12669/pjms.311.6524.

Association of SNP rs9939609 in FTO gene with metabolic syndrome in type 2 diabetic subjects, rectruited from a tertiary care unit of Karachi, Pakistan.

Pakistan journal of medical sciences

Asher Fawwad, Iftikhar Ahmed Siddiqui, Nimra Fatima Zeeshan, Syed Muhammad Shahid, Abdul Basit

Affiliations

  1. Asher Fawwad, M.Phil. Assistant Professor, Senior Research Scientist, Research Department, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Plot No. 1-2, II-B, Nazimabad No2, Karachi-74600, Pakistan.
  2. Iftikhar Ahmed Siddiqui, PhD. Chairman& Professor of Biochemistry, Department of Biochemistry, Baqai Medical University, Pakistan.
  3. Nimra Fatima Zeeshan, B.E (Bio Engineering). Research Officer, Research Department, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Plot No. 1-2, II-B, Nazimabad No2, Karachi-74600, Pakistan.
  4. Syed Muhammad Shahid, Assistant Professor,The Karachi Institute of Biotechnology & Genetic Engineering (KIBGE), University of Karachi, Karachi-75270, Pakistan.
  5. Abdul Basit, FRCP. Professor of Medicine, Department of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Plot No. 1-2, II-B, Nazimabad No2, Karachi-74600, Pakistan.

PMID: 25878631 PMCID: PMC4386174 DOI: 10.12669/pjms.311.6524

Abstract

OBJECTIVE: To determine the association of SNP in FTO gene, rs9939609, with Metabolic Syndrome (MS) in type 2 diabetic subjects at a tertiary care unit of Karachi, Pakistan.

METHODS: We genotyped FTO rs9939609 SNP in 296 patients with type 2 diabetes from the Out Patient Department (OPD) of Baqai Institute of Diabetology and Endocrinology (BIDE). MS was defined on the basis of International Diabetes Federation (IDF) and National Cholesterol Education program (NCEP) criterion. Association between the rs9939609 SNP and MS was tested through chi-square and Z-tests by using odds ratio (OR) with 95% confidence intervals.

RESULTS: The frequency of MS as defined by IDF criterion was significantly higher in female subjects as compared to male subjects (p= 0.006). Carriers of ≥ 1 copy of the rs9939609 A allele were significantly more likely to had MS (69.6%) than non-carriers (30.4%), corresponding to a carrier odds ratio (OR) of 0.52 (95% confidence interval [CI] (0.29-0.93), with a similar trend for the ATP III-defined MS."A" allele carriers under dominant model, carry all the criterion of MS more significantly as compared to non-carriers.

CONCLUSION: The FTO rs9939609 SNP was associated with an increased risk for Metabolic Syndrome in type 2 diabetic populations at a tertiary care unit of Karachi, Pakistan.

Keywords: Association study; FTO-rs9939609; Metabolic Syndrome; type 2 diabetes

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