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Li XS, Yang WL, Shen FZ, et al. Short-term therapeutic effects of low-dose cytarabine plus surgical resection on elderly patients with trigeminal nerve tumor and safety observation. Pak J Med Sci. 2015;31(1):178-82doi: 10.12669/pjms.311.6440.
Li, X. S., Yang, W. L., Shen, F. Z., Gao, G. J., Ma, J. W., & Jin, B. Z. (2015). Short-term therapeutic effects of low-dose cytarabine plus surgical resection on elderly patients with trigeminal nerve tumor and safety observation. Pakistan journal of medical sciences, 31(1), 178-82. https://doi.org/10.12669/pjms.311.6440
Li, Xiang-Sheng, et al. "Short-term therapeutic effects of low-dose cytarabine plus surgical resection on elderly patients with trigeminal nerve tumor and safety observation." Pakistan journal of medical sciences vol. 31,1 (2015): 178-82. doi: https://doi.org/10.12669/pjms.311.6440
Li XS, Yang WL, Shen FZ, Gao GJ, Ma JW, Jin BZ. Short-term therapeutic effects of low-dose cytarabine plus surgical resection on elderly patients with trigeminal nerve tumor and safety observation. Pak J Med Sci. 2015 Jan-Feb;31(1):178-82. doi: 10.12669/pjms.311.6440. PMID: 25878639; PMCID: PMC4386182.
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Pak J Med Sci. 2015 Jan-Feb;31(1):178-82. doi: 10.12669/pjms.311.6440.

Short-term therapeutic effects of low-dose cytarabine plus surgical resection on elderly patients with trigeminal nerve tumor and safety observation.

Pakistan journal of medical sciences

Xiang-Sheng Li, Wei-Long Yang, Fa-Zheng Shen, Guo-Jun Gao, Ji-Wei Ma, Bao-Zhe Jin

Affiliations

  1. Xiang-Sheng Li, Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, PR China.
  2. Wei-Long Yang, Department of Neurosurgery, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, PR China.
  3. Fa-Zheng Shen, Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, PR China.
  4. Guo-Jun Gao, Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, PR China.
  5. Ji-Wei Ma, Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, PR China.
  6. Bao-Zhe Jin, Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, PR China.

PMID: 25878639 PMCID: PMC4386182 DOI: 10.12669/pjms.311.6440

Abstract

OBJECTIVE: To evaluate the short-term therapeutic effects of low-dose cytarabine plus surgical resection on elderly patients with trigeminal nerve tumor and to observe the safety.

METHODS: A total of 120 elderly patients with trigeminal nerve tumor were divided into a treatment group and a control group by random draw (n=60), and both groups were subjected to resection by stereotactic image-guided endoscopic nasal surgery. Afterwards, the control group was administered with high-dose cytarabine while the treatment group was given low-dose cytarabine for 14 days.

RESULTS: Both groups completed treatment, but the effective rate of the treatment group (96.7%) was significantly higher than that of the control group (83.3%) (P < 0.05). The pain scores of the two groups were similar at T0, T1 and T2, but the score of the treatment group at T2 was significantly different from those at T0 and T1 (P < 0.05). During treatment, the treatment group was significantly less prone to complications such as headache, vomiting, vision impairment, nausea and local swelling than the control group (P < 0.05). During three months of follow-up, the appetite, sleep and daily living scores were significantly higher than those of the control group (P < 0.05).

CONCLUSION: Stereotactic image-guided surgery was able to treat trigeminal nerve tumor well, and the effect was enhanced by low-dose cytarabine that improved postoperative outcomes and quality of life by dramatically decreasing complications.

Keywords: Cytarabine; Dose; Safety; Surgical resection; Trigeminal nerve tumor

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