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Sivva D, Mateti UV, Neerati VM, et al. Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital. Avicenna J Med. 2015;5(2):29-35doi: 10.4103/2231-0770.154194.
Sivva, D., Mateti, U. V., Neerati, V. M., Thiruthopu, N. S., & Martha, S. (2015). Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital. Avicenna journal of medicine, 5(2), 29-35. https://doi.org/10.4103/2231-0770.154194
Sivva, Divya, et al. "Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital." Avicenna journal of medicine vol. 5,2 (2015): 29-35. doi: https://doi.org/10.4103/2231-0770.154194
Sivva D, Mateti UV, Neerati VM, Thiruthopu NS, Martha S. Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital. Avicenna J Med. 2015 Apr-Jun;5(2):29-35. doi: 10.4103/2231-0770.154194. PMID: 25878964; PMCID: PMC4394569.
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Avicenna J Med. 2015 Apr-Jun;5(2):29-35. doi: 10.4103/2231-0770.154194.

Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital.

Avicenna journal of medicine

Divya Sivva, Uday Venkat Mateti, Venu Madhav Neerati, Nimbagiri Swamy Thiruthopu, Srinivas Martha

Affiliations

  1. Department of Pharmacy Practice, St. Peter's Institute of Pharmaceutical Sciences, Kakatiya University, Hanamkonda, Warangal, Andhra Pradesh, India.
  2. Department of Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.
  3. Department of Pharmaceutical Analysis, St. Peter's Institute of Pharmaceutical Sciences, Kakatiya University, Hanamkonda, Warangal, Andhra Pradesh, India.
  4. Department of Pharmacology, Balaji Institute of Pharmacy, Laknepally, Narsampet, Warangal, Telangana, India.

PMID: 25878964 PMCID: PMC4394569 DOI: 10.4103/2231-0770.154194

Abstract

OBJECTIVE: The objective of the study was to assess the incidence and pattern of drug-drug interactions (DDIs) in hypertensive patients by using Micromedex and Medscape databases.

MATERIALS AND METHODS: A prospective observational study was carried out in a superspeciality hospital setting in South India for period of 9 months. Hypertensive patients who admitted into the hospital with the age more than 18 years, received more than 3 drugs per prescription and length of hospital stay for more than 24 hours were included in the study. An appropriate data was collected and assessed for DDIs with the help of Micromedex and Medscape databases.

RESULTS: A total of 227 patients were enrolled during the study period. Among the 227 patients, 48 of them developed 53 clinically significant DDIs. Out of 48 patients, most of them were in the age-group of 50-60 years [18 (37.49%)]. The percentage of DDIs were higher in males [30 (62.5%)] compared to females [18 (37.5%)]. The most common drugs responsible for DDIs in the present study were Insulin [18 (33.96%)] followed by Metoprolol [10 (18.86%)], Torsemide [8 (15.09%)], and Hydrochlorothiazide [8 (15.09%)]. The most commonly interacting pairs were Ciprofloxacin-Insulin [6 (11.32%)], followed by Metoprolol-Insulin [4 (7.54%)] and Atenolol-Insulin [4 (7.54%)]. The most common consequences of interacting pairs were reduced serum potassium levels and hyperglycemia.

CONCLUSION: The overall incidence rate of DDIs was found to be 21.14% and the increasing number of co-morbidities (P ≤ 0.003) and polypharmacy (P ≤ 0.002) were the risk factor for the development of significant number of DDIs.

Keywords: Drug-drug interactions; hypertension; incidence; medscape; micromedex

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