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Liang K, Traverso G, Lee HC, et al. Ultrahigh speed en face OCT capsule for endoscopic imaging. Biomed Opt Express. 2015;6(4):1146-63doi: 10.1364/BOE.6.001146.
Liang, K., Traverso, G., Lee, H. C., Ahsen, O. O., Wang, Z., Potsaid, B., Giacomelli, M., Jayaraman, V., Barman, R., Cable, A., Mashimo, H., Langer, R., & Fujimoto, J. G. (2015). Ultrahigh speed en face OCT capsule for endoscopic imaging. Biomedical optics express, 6(4), 1146-63. https://doi.org/10.1364/BOE.6.001146
Liang, Kaicheng, et al. "Ultrahigh speed en face OCT capsule for endoscopic imaging." Biomedical optics express vol. 6,4 (2015): 1146-63. doi: https://doi.org/10.1364/BOE.6.001146
Liang K, Traverso G, Lee HC, Ahsen OO, Wang Z, Potsaid B, Giacomelli M, Jayaraman V, Barman R, Cable A, Mashimo H, Langer R, Fujimoto JG. Ultrahigh speed en face OCT capsule for endoscopic imaging. Biomed Opt Express. 2015 Mar 05;6(4):1146-63. doi: 10.1364/BOE.6.001146. eCollection 2015 Apr 01. PMID: 25909001; PMCID: PMC4399656.
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Biomed Opt Express. 2015 Mar 05;6(4):1146-63. doi: 10.1364/BOE.6.001146. eCollection 2015 Apr 01.

Ultrahigh speed en face OCT capsule for endoscopic imaging.

Biomedical optics express

Kaicheng Liang, Giovanni Traverso, Hsiang-Chieh Lee, Osman Oguz Ahsen, Zhao Wang, Benjamin Potsaid, Michael Giacomelli, Vijaysekhar Jayaraman, Ross Barman, Alex Cable, Hiroshi Mashimo, Robert Langer, James G Fujimoto

Affiliations

  1. Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
  2. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA ; Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA ; Harvard Medical School, Boston MA, USA.
  3. Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA ; Advanced Imaging Group, Thorlabs Inc., Newton NJ, USA.
  4. Praevium Research Inc., Santa Barbara CA, USA.
  5. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA.
  6. Advanced Imaging Group, Thorlabs Inc., Newton NJ, USA.
  7. Harvard Medical School, Boston MA, USA ; Veterans Affairs Boston Healthcare System, Boston MA, USA.
  8. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA ; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge MA, USA.

PMID: 25909001 PMCID: PMC4399656 DOI: 10.1364/BOE.6.001146

Abstract

Depth resolved and en face OCT visualization in vivo may have important clinical applications in endoscopy. We demonstrate a high speed, two-dimensional (2D) distal scanning capsule with a micromotor for fast rotary scanning and a pneumatic actuator for precision longitudinal scanning. Longitudinal position measurement and image registration were performed by optical tracking of the pneumatic scanner. The 2D scanning device enables high resolution imaging over a small field of view and is suitable for OCT as well as other scanning microscopies. Large field of view imaging for screening or surveillance applications can also be achieved by proximally pulling back or advancing the capsule while scanning the distal high-speed micromotor. Circumferential en face OCT was demonstrated in living swine at 250 Hz frame rate and 1 MHz A-scan rate using a MEMS tunable VCSEL light source at 1300 nm. Cross-sectional and en face OCT views of the upper and lower gastrointestinal tract were generated with precision distal pneumatic longitudinal actuation as well as proximal manual longitudinal actuation. These devices could enable clinical studies either as an adjunct to endoscopy, attached to an endoscope, or as a swallowed tethered capsule for non-endoscopic imaging without sedation. The combination of ultrahigh speed imaging and distal scanning capsule technology could enable both screening and surveillance applications.

Keywords: (170.2150) Endoscopic imaging; (170.2680) Gastrointestinal; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography

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