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Kiseleva E, Kirillin M, Feldchtein F, et al. Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography. Biomed Opt Express. 2015;6(4):1464-76doi: 10.1364/BOE.6.001464.
Kiseleva, E., Kirillin, M., Feldchtein, F., Vitkin, A., Sergeeva, E., Zagaynova, E., Streltzova, O., Shakhov, B., Gubarkova, E., & Gladkova, N. (2015). Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography. Biomedical optics express, 6(4), 1464-76. https://doi.org/10.1364/BOE.6.001464
Kiseleva, Elena, et al. "Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography." Biomedical optics express vol. 6,4 (2015): 1464-76. doi: https://doi.org/10.1364/BOE.6.001464
Kiseleva E, Kirillin M, Feldchtein F, Vitkin A, Sergeeva E, Zagaynova E, Streltzova O, Shakhov B, Gubarkova E, Gladkova N. Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography. Biomed Opt Express. 2015 Mar 24;6(4):1464-76. doi: 10.1364/BOE.6.001464. eCollection 2015 Apr 01. PMID: 25909028; PMCID: PMC4399683.
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Biomed Opt Express. 2015 Mar 24;6(4):1464-76. doi: 10.1364/BOE.6.001464. eCollection 2015 Apr 01.

Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography.

Biomedical optics express

Elena Kiseleva, Mikhail Kirillin, Felix Feldchtein, Alex Vitkin, Ekaterina Sergeeva, Elena Zagaynova, Olga Streltzova, Boris Shakhov, Ekaterina Gubarkova, Natalia Gladkova

Affiliations

  1. Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia.
  2. Institute of Applied Physics RAS, 603950, Ulyanov Street, 46, Nizhny Novgorod, Russia ; N.I. Lobachevsky State University of Nizhny Novgorod, 603950, 23 Gagarin St., Nizhny Novgorod, Russia.
  3. Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia ; Department of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario M5G 2M9, Canada ; Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2M9, Canada.

PMID: 25909028 PMCID: PMC4399683 DOI: 10.1364/BOE.6.001464

Abstract

Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is thus demonstrated in vivo.

Keywords: (100.2960) Image analysis; (110.4500) Optical coherence tomography; (170.1610) Clinical applications; (170.7230) Urology; (230.5440) Polarization-selective devices; (290.5855) Scattering, polarization

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