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Barry G, Guennewig B, Fung S, et al. Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone. Front Neurol. 2015;6:45doi: 10.3389/fneur.2015.00045.
Barry, G., Guennewig, B., Fung, S., Kaczorowski, D., & Weickert, C. S. (2015). Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone. Frontiers in neurology, 645. https://doi.org/10.3389/fneur.2015.00045
Barry, Guy, et al. "Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone." Frontiers in neurology vol. 6 (2015): 45. doi: https://doi.org/10.3389/fneur.2015.00045
Barry G, Guennewig B, Fung S, Kaczorowski D, Weickert CS. Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone. Front Neurol. 2015 Mar 09;6:45. doi: 10.3389/fneur.2015.00045. eCollection 2015. PMID: 25806019; PMCID: PMC4353253.
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Front Neurol. 2015 Mar 09;6:45. doi: 10.3389/fneur.2015.00045. eCollection 2015.

Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone.

Frontiers in neurology

Guy Barry, Boris Guennewig, Samantha Fung, Dominik Kaczorowski, Cynthia Shannon Weickert

Affiliations

  1. Garvan Institute of Medical Research , Sydney, NSW , Australia ; St Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales , Sydney, NSW , Australia.
  2. Schizophrenia Research Institute , Sydney, NSW , Australia ; Schizophrenia Research Laboratory, Neuroscience Research Australia , Sydney, NSW , Australia ; School of Psychiatry, University of New South Wales , Sydney, NSW , Australia.
  3. Garvan Institute of Medical Research , Sydney, NSW , Australia.

PMID: 25806019 PMCID: PMC4353253 DOI: 10.3389/fneur.2015.00045

Abstract

The human subependymal zone (SEZ) is debatably a source of newly born neurons throughout life and neurogenesis is a multi-step process requiring distinct transcripts during cell proliferation and early neuronal maturation, along with orchestrated changes in gene expression during cell state/fate transitions. Furthermore, it is becoming increasingly clear that the majority of our genome that results in production of non-protein-coding RNAs plays vital roles in the evolution, development, adaptation, and region-specific function of the human brain. We predicted that some transcripts expressed in the SEZ may be unique to this specialized brain region, and that a comprehensive transcriptomic analysis of this region would aid in defining expression changes during neuronal birth and growth in adult humans. Here, we used deep RNA sequencing of human SEZ tissue during adulthood and aging to characterize the transcriptional landscape with a particular emphasis on long non-coding RNAs (lncRNAs). The data show predicted age-related changes in mRNAs encoding proliferation, progenitor, and inflammatory proteins as well as a unique subset of lncRNAs that are highly expressed in the human SEZ, many of which have unknown functions. Our results suggest the existence of robust proliferative and neuronal differentiation potential in the adult human SEZ and lay the foundation for understanding the involvement of lncRNAs in postnatal neurogenesis and potentially associated neurodevelopmental diseases that emerge after birth.

Keywords: aging; interneuron; long non-coding RNA; neurodevelopmental disease; neurogenesis; subependymal zone

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