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Huang Md H, Chan Md J, Wittner Md PhD M, et al. Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase. Cardiovasc Pathol. 1997;6(3):161-6doi: 10.1016/s1054-8807(96)00094-4.
Huang Md, H., Chan Md, J., Wittner Md PhD, M., Weiss Md Mph, L. M., Bacchi PhD, J., Yarlett PhD, N., Martinez Ba, M., Morris Md PhD, S. A., Braunstein Bs, V. L., Factor Md, S. M., & Tanowitz Md, H. B. (1997). Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 6(3), 161-6. https://doi.org/10.1016/s1054-8807(96)00094-4
Huang Md, H, et al. "Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase." Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology vol. 6,3 (1997): 161-6. doi: https://doi.org/10.1016/s1054-8807(96)00094-4
Huang Md H, Chan Md J, Wittner Md PhD M, Weiss Md Mph LM, Bacchi PhD J, Yarlett PhD N, Martinez Ba M, Morris Md PhD SA, Braunstein Bs VL, Factor Md SM, Tanowitz Md HB. Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase. Cardiovasc Pathol. 1997 May-Jun;6(3):161-6. doi: 10.1016/s1054-8807(96)00094-4. PMID: 25850327.
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Cardiovasc Pathol. 1997 May-Jun;6(3):161-6. doi: 10.1016/s1054-8807(96)00094-4.

Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

H Huang Md, J Chan Md, M Wittner Md PhD, L M Weiss Md Mph, J Bacchi PhD, N Yarlett PhD, M Martinez Ba, S A Morris Md PhD, V L Braunstein Bs, S M Factor Md, H B Tanowitz Md

Affiliations

  1. Pathology, Albert Einstein College of Medicine, Bronx, New York USA.
  2. Medicine, Albert Einstein College of Medicine, Bronx, New York USA.
  3. Pathology, Albert Einstein College of Medicine, Bronx, New York USA; Medicine, Albert Einstein College of Medicine, Bronx, New York USA.
  4. Haskins Laboratory and the Biology Department, Pace University, New York, New York USA.

PMID: 25850327 DOI: 10.1016/s1054-8807(96)00094-4

Abstract

Chagas' disease caused by Trypanosoma cruzi, is an important cause of myocarditis and cardiomyopathy. Acute and chronic infection is associated with myocardial dysfunction, including dysrhythmias, conduction disturbances, and congestive heart failure. Nitric oxide (NO) has been implicated in the myocardial dysfunction associated with diseases of the myocardium. The inducible form of nitric oxide synthase (iNOS) mediates the synthesis of NO and L-citrulline from L-arginine. An abundance of iNOS mRNA by Northern blot and a marked expression of iNOS protein by Western blot was demonstrated in the myocardium of mice 30 days postinfection with the Brazil strain of T. cruzi. Immunocytochemical staining of the myocardial sections from infected mice also revealed the expression of iNOS. Consistent with these observations, the myocardial L-citrulline content was higher in infected mice, confirming NO expression in vivo. In addition, Northern blot analysis revealed that interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) mRNA were induced during infection. These data suggest that the myocardial cytokine-iNOS pathway may be an important factor in the pathogenesis of chagasic heart disease. In addition, this pathway may be a potential target of future pharmacologic intervention.

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