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Muley TR, Herth FJ, Schnabel PA, et al. From tissue to molecular phenotyping: pre-analytical requirements heidelberg experience. Transl Lung Cancer Res. 2012;1(2):111-21doi: 10.3978/j.issn.2218-6751.2011.12.07.
Muley, T. R., Herth, F. J., Schnabel, P. A., Dienemann, H., & Meister, M. (2012). From tissue to molecular phenotyping: pre-analytical requirements heidelberg experience. Translational lung cancer research, 1(2), 111-21. https://doi.org/10.3978/j.issn.2218-6751.2011.12.07
Muley, Thomas R, et al. "From tissue to molecular phenotyping: pre-analytical requirements heidelberg experience." Translational lung cancer research vol. 1,2 (2012): 111-21. doi: https://doi.org/10.3978/j.issn.2218-6751.2011.12.07
Muley TR, Herth FJ, Schnabel PA, Dienemann H, Meister M. From tissue to molecular phenotyping: pre-analytical requirements heidelberg experience. Transl Lung Cancer Res. 2012 Jun;1(2):111-21. doi: 10.3978/j.issn.2218-6751.2011.12.07. PMID: 25806167; PMCID: PMC4367579.
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Transl Lung Cancer Res. 2012 Jun;1(2):111-21. doi: 10.3978/j.issn.2218-6751.2011.12.07.

From tissue to molecular phenotyping: pre-analytical requirements heidelberg experience.

Translational lung cancer research

Thomas R Muley, Felix Jf Herth, Philipp A Schnabel, Hendrik Dienemann, Michael Meister

Affiliations

  1. Translational Research Unit;
  2. Department of Pneumology and Respiratory Medicine, Thoraxklinik-Heidelberg gGmbH, University of Heidelberg, Germany ;
  3. Institute of Pathology, University of Heidelberg, Germany ;
  4. Department of Surgery, Thoraxklinik-Heidelberg gGmbH, University of Heidelberg, Germany.

PMID: 25806167 PMCID: PMC4367579 DOI: 10.3978/j.issn.2218-6751.2011.12.07

Abstract

Lung cancer is a leading cause of tumor-related death worldwide through years. Efforts to individualize lung cancer therapy to improve prognosis nowadays employ molecular analyses besides routine histopathological examination of tissue samples. In general, tissues are provided by bronchoscopy, CT-guided procedures or surgery. The sequence of tissue removal, storage, and processing has a considerable impact on the success and reliability of subsequent molecular biological analyses and will supposedly also influence therapeutic decisions. There is still an ongoing need for updated statements about the minimal requirements of tissue sampling for molecular diagnosis at international level and for certified/accredited quality control programs of the sampling procedures. Several of these issues may have to be adjusted to the individual local conditions. We will present several aspects of experiences gained in Thoraxklinik at the University Hospital of Heidelberg (TK-HD) with pre-analytical tissue requirements.

Keywords: Lung cancer; molecular phenotyping; pre-analytical tissue

References

  1. Eur J Cancer. 2009 May;45(8):1389-96 - PubMed
  2. J Cancer Res Ther. 2010 Apr-Jun;6(2):134-41 - PubMed
  3. Am Rev Respir Dis. 1982 May;125(5):521-3 - PubMed
  4. Am J Clin Pathol. 2011 Oct;136(4):527-39 - PubMed
  5. Dtsch Arztebl Int. 2011 Aug;108(31-32):525-31 - PubMed
  6. Lung. 2009 Jan-Feb;187(1):55-9 - PubMed
  7. Lung Cancer. 2003 Sep;41(3):245-58 - PubMed
  8. Chest. 2000 Apr;117(4):1049-54 - PubMed
  9. J Clin Oncol. 2012 May 1;30(13):1438-46 - PubMed
  10. Cancer Res. 2009 Mar 15;69(6):2234-43 - PubMed
  11. Respir Res. 2003;4:12 - PubMed
  12. N Engl J Med. 2008 Sep 25;359(13):1367-80 - PubMed
  13. Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):601-7 - PubMed
  14. AJR Am J Roentgenol. 2010 Jan;194(1):266-9 - PubMed
  15. Cytopathology. 2011 Oct;22(5):306-12 - PubMed
  16. CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 - PubMed
  17. Chest. 2007 Jun;131(6):1800-5 - PubMed
  18. Chest. 2010 Oct;138(4):790-4 - PubMed
  19. Clin Cancer Res. 2010 Oct 15;16(20):4938-45 - PubMed
  20. Clin Cancer Res. 2010 Apr 1;16(7):2198-204 - PubMed
  21. Eur Respir J. 2012 Mar;39(3):685-90 - PubMed
  22. Pathologe. 2008 Nov;29 Suppl 2:204-9 - PubMed
  23. J Thorac Oncol. 2010 Jul;5(7):956-63 - PubMed
  24. Eur Respir J. 2001 Mar;17(3):507-28 - PubMed
  25. Lung Cancer. 2007 Jun;56(3):295-302 - PubMed
  26. BMC Mol Biol. 2006 Jan 31;7:3 - PubMed
  27. Cancer Cell. 2010 Dec 14;18(6):548-51 - PubMed
  28. N Engl J Med. 2004 May 20;350(21):2129-39 - PubMed
  29. Chest. 2004 Feb;125(2):532-40 - PubMed
  30. N Engl J Med. 2007 Jan 4;356(1):76-8 - PubMed
  31. Lung Cancer. 2010 Feb;67(2):166-9 - PubMed
  32. Pathol Res Pract. 2005;201(8-9):599-602 - PubMed
  33. Biotechniques. 1999 May;26(5):884-6, 888-92 - PubMed
  34. J Thorac Oncol. 2011 Jan;6(1):203-6 - PubMed
  35. J Thorac Oncol. 2011 Nov;6(11 Suppl 4):S1758-85 - PubMed
  36. Chest. 2007 Feb;131(2):539-48 - PubMed
  37. Cardiovasc Intervent Radiol. 2000 Jul-Aug;23 (4):266-72 - PubMed
  38. Pathol Res Pract. 2001;197(12):823-6 - PubMed
  39. J Thorac Oncol. 2011 Feb;6(2):244-85 - PubMed
  40. Virchows Arch. 2010 Dec;457(6):741-7 - PubMed
  41. Lung Cancer. 2009 Jan;63(1):32-8 - PubMed
  42. Chest. 1999 May;115(5):1237-41 - PubMed
  43. J Thorac Oncol. 2010 Apr;5(4):448-52 - PubMed
  44. Thorax. 1982 Sep;37(9):684-7 - PubMed
  45. Chest. 1988 Jun;93(6):1152-5 - PubMed
  46. JAMA. 2010 Nov 24;304(20):2245-52 - PubMed

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