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Kura AU, Saifullah B, Cheah PS, et al. Acute oral toxicity and biodistribution study of zinc-aluminium-levodopa nanocomposite. Nanoscale Res Lett. 2015;10:105doi: 10.1186/s11671-015-0742-5.
Kura, A. U., Saifullah, B., Cheah, P. S., Hussein, M. Z., Azmi, N., & Fakurazi, S. (2015). Acute oral toxicity and biodistribution study of zinc-aluminium-levodopa nanocomposite. Nanoscale research letters, 10105. https://doi.org/10.1186/s11671-015-0742-5
Kura, Aminu Umar, et al. "Acute oral toxicity and biodistribution study of zinc-aluminium-levodopa nanocomposite." Nanoscale research letters vol. 10 (2015): 105. doi: https://doi.org/10.1186/s11671-015-0742-5
Kura AU, Saifullah B, Cheah PS, Hussein MZ, Azmi N, Fakurazi S. Acute oral toxicity and biodistribution study of zinc-aluminium-levodopa nanocomposite. Nanoscale Res Lett. 2015 Mar 01;10:105. doi: 10.1186/s11671-015-0742-5. eCollection 2015. PMID: 25852400; PMCID: PMC4385219.
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Nanoscale Res Lett. 2015 Mar 01;10:105. doi: 10.1186/s11671-015-0742-5. eCollection 2015.

Acute oral toxicity and biodistribution study of zinc-aluminium-levodopa nanocomposite.

Nanoscale research letters

Aminu Umar Kura, Bullo Saifullah, Pike-See Cheah, Mohd Zobir Hussein, Norazrina Azmi, Sharida Fakurazi

Affiliations

  1. Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Selangor, Malaysia.
  2. Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
  3. Neurobiology and Genetic Group, Genetic Medicine Research Centre, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia ; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  4. Faculty of Pharmacy, Universiti Kebangsan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lampur, Malaysia.
  5. Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Selangor, Malaysia ; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

PMID: 25852400 PMCID: PMC4385219 DOI: 10.1186/s11671-015-0742-5

Abstract

Layered double hydroxide (LDH) is an inorganic-organic nano-layered material that harbours drug between its two-layered sheets, forming a sandwich-like structure. It is attracting a great deal of attention as an alternative drug delivery (nanodelivery) system in the field of pharmacology due to their relative low toxic potential. The production of these nanodelivery systems, aimed at improving human health through decrease toxicity, targeted delivery of the active compound to areas of interest with sustained release ability. In this study, we administered zinc-aluminium-LDH-levodopa nanocomposite (ZAL) and zinc-aluminium nanocomposite (ZA) to Sprague Dawley rats to evaluate for acute oral toxicity following OECD guidelines. The oral administration of ZAL and ZA at a limit dose of 2,000 mg/kg produced neither mortality nor acute toxic signs throughout 14 days of the observation. The percentage of body weight gain of the animals showed no significant difference between control and treatment groups. Animal from the two treated groups gained weight continuously over the study period, which was shown to be significantly higher than the weight at the beginning of the study (P < 0.05). Biochemical analysis of animal serum showed no significant difference between rats treated with ZAL, ZA and controls. There was no gross lesion or histopathological changes observed in vital organs of the rats. The results suggested that ZAL and ZA at 2,000 mg/kg body weight in rats do not induce acute toxicity in the animals. Elemental analysis of tissues of treated animals demonstrated the wider distribution of the nanocomposite including the brain. In summary, findings of acute toxicity tests in this study suggest that zinc-aluminium nanocomposite intercalated with and the un-intercalated were safe when administered orally in animal models for short periods of time. It also highlighted the potential distribution ability of Tween-80 coated nanocomposite after oral administration.

Keywords: Acute toxicity; Layered hydroxide; Levodopa; Nanocomposite

References

  1. Part Fibre Toxicol. 2009 Apr 30;6:14 - PubMed
  2. Rheumatol Int. 2011 Jan;31(1):79-84 - PubMed
  3. J Nutr. 2000 May;130(5S Suppl):1360S-6S - PubMed
  4. Toxicol Lett. 2009 Sep 28;189(3):177-83 - PubMed
  5. Toxicol Lett. 2006 Feb 20;161(2):115-23 - PubMed
  6. J Control Release. 2012 Jul 20;161(2):264-73 - PubMed
  7. Drug Des Devel Ther. 2013 Nov 13;7:1365-75 - PubMed
  8. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2073-89 - PubMed
  9. Nanotechnol Sci Appl. 2012 Aug 15;5:61-71 - PubMed
  10. J Diabetes Sci Technol. 2009 May 01;3(3):562-7 - PubMed
  11. Chem Cent J. 2014 Aug 10;8(1):47 - PubMed
  12. Eur J Pharm Sci. 2014 Oct 15;63:63-70 - PubMed
  13. Nanoscale Res Lett. 2014 May 24;9(1):261 - PubMed
  14. J Nanosci Nanotechnol. 2008 Oct;8(10):5297-301 - PubMed
  15. Int J Nanomedicine. 2013;8:1103-10 - PubMed
  16. Curr Pharm Des. 2004;10(12):1355-63 - PubMed
  17. ScientificWorldJournal. 2014 Mar 23;2014:104246 - PubMed
  18. J Nanosci Nanotechnol. 2010 Apr;10(4):2913-6 - PubMed
  19. Am J Gastroenterol. 1999 Apr;94(4):1018-22 - PubMed
  20. Drugs Aging. 1999 Jun;14(6):399-408 - PubMed
  21. Toxicol Lett. 2007 Jan 30;168(2):176-85 - PubMed
  22. Clin Pharmacokinet. 2002;41(9):661-80 - PubMed
  23. Mol Pharm. 2008 Jul-Aug;5(4):496-504 - PubMed
  24. Am J Clin Nutr. 2000 Aug;72(2 Suppl):564S-72S - PubMed
  25. Toxicol Sci. 2008 Feb;101(2):183-5 - PubMed
  26. J Cereb Blood Flow Metab. 2012 Nov;32(11):1959-72 - PubMed
  27. J Biomater Sci Polym Ed. 2007;18(3):241-68 - PubMed
  28. Biomaterials. 2004 Jul;25(15):3065-71 - PubMed
  29. Nat Clin Pract Nephrol. 2006 Feb;2(2):80-91 - PubMed
  30. Am Fam Physician. 2005 Mar 15;71(6):1105-10 - PubMed

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