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Ramsay G, Cantrell D. Environmental and metabolic sensors that control T cell biology. Front Immunol. 2015;6:99doi: 10.3389/fimmu.2015.00099.
Ramsay, G., & Cantrell, D. (2015). Environmental and metabolic sensors that control T cell biology. Frontiers in immunology, 699. https://doi.org/10.3389/fimmu.2015.00099
Ramsay, George, and Cantrell, Doreen. "Environmental and metabolic sensors that control T cell biology." Frontiers in immunology vol. 6 (2015): 99. doi: https://doi.org/10.3389/fimmu.2015.00099
Ramsay G, Cantrell D. Environmental and metabolic sensors that control T cell biology. Front Immunol. 2015 Mar 17;6:99. doi: 10.3389/fimmu.2015.00099. eCollection 2015. PMID: 25852681; PMCID: PMC4362047.
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Front Immunol. 2015 Mar 17;6:99. doi: 10.3389/fimmu.2015.00099. eCollection 2015.

Environmental and metabolic sensors that control T cell biology.

Frontiers in immunology

George Ramsay, Doreen Cantrell

Affiliations

  1. Division of Cell Signalling and Immunology, University of Dundee , Dundee , UK.

PMID: 25852681 PMCID: PMC4362047 DOI: 10.3389/fimmu.2015.00099

Abstract

The T lymphocyte response to pathogens is shaped by the microenvironment. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1. Other environmental sensors are transcription factors such as hypoxia-inducible factor-1 and the aryl hydrocarbon receptor. The present review explores the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.

Keywords: T cell metabolism; amino acid uptake; aryl hydrocarbon; glucose uptake; hypoxia; leucine and mTOR; microbiome

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