Display options
Cite
Petrushkin H, Hasan MS, Stanford MR, et al. Behçet's Disease: Do Natural Killer Cells Play a Significant Role?. Front Immunol. 2015;6:134doi: 10.3389/fimmu.2015.00134.
Petrushkin, H., Hasan, M. S., Stanford, M. R., Fortune, F., & Wallace, G. R. (2015). Behçet's Disease: Do Natural Killer Cells Play a Significant Role?. Frontiers in immunology, 6134. https://doi.org/10.3389/fimmu.2015.00134
Petrushkin, Harry, et al. "Behçet's Disease: Do Natural Killer Cells Play a Significant Role?." Frontiers in immunology vol. 6 (2015): 134. doi: https://doi.org/10.3389/fimmu.2015.00134
Petrushkin H, Hasan MS, Stanford MR, Fortune F, Wallace GR. Behçet's Disease: Do Natural Killer Cells Play a Significant Role?. Front Immunol. 2015 Mar 24;6:134. doi: 10.3389/fimmu.2015.00134. eCollection 2015. PMID: 25852697; PMCID: PMC4371743.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2015 Mar 24;6:134. doi: 10.3389/fimmu.2015.00134. eCollection 2015.

Behçet's Disease: Do Natural Killer Cells Play a Significant Role?.

Frontiers in immunology

Harry Petrushkin, Md Samiul Hasan, Miles R Stanford, Farida Fortune, Graham R Wallace

Affiliations

  1. Clinical and Diagnostic Oral Sciences, Queen Mary University of London , London , UK.
  2. Academic Unit of Ophthalmology, St Thomas's Hospital , London , UK.
  3. Centre for Translational Inflammation Research, University of Birmingham , Birmingham , UK.

PMID: 25852697 PMCID: PMC4371743 DOI: 10.3389/fimmu.2015.00134

Abstract

Behçet's disease (BD) is a complex inflammatory disease, of unknown etiology. While disease pathogenesis remains unclear, a strong relationship between BD and HLA-B*51 has been established over the last 30 years. A number of theories exist regarding the cause of BD; however, few are able to account for the increased rates of HLA-B*51 positive individuals, particularly around the Mediterranean basin and Middle-East where the prevalence is highest. This review outlines current immunogenetic data on BD and the immunoregulatory role natural killer cells may play. It also describes the interaction of the killer immunoglobulin-like receptor - KIR3DL1 with its ligand Bw4, which is found on HLA-B51. Finally, CD94/NKG2D, MICA, and ERAP are outlined with regard to their potential roles in BD.

Keywords: Behçet’s; Behçet’s disease; Behçet’s syndrome; HLA-B antigens; HLA-B*51; KIR; KIR3DL1; NK cells

References

  1. J Rheumatol. 2000 Sep;27(9):2193-7 - PubMed
  2. Genes Immun. 2014 Jan;15(1):8-15 - PubMed
  3. Eur J Immunogenet. 1997 Dec;24(6):455-68 - PubMed
  4. J Exp Med. 1998 Mar 2;187(5):813-8 - PubMed
  5. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8867-72 - PubMed
  6. Immunobiology. 2013 Sep;218(9):1119-30 - PubMed
  7. Nature. 1991 Jan 24;349(6307):329-31 - PubMed
  8. J Korean Med Sci. 2002 Jun;17(3):366-70 - PubMed
  9. Arch Ophthalmol. 1982 Sep;100(9):1455-8 - PubMed
  10. J Exp Med. 1997 Oct 6;186(7):1129-36 - PubMed
  11. Scand J Immunol. 2006 Dec;64(6):655-60 - PubMed
  12. Blood. 2001 May 15;97(10):3146-51 - PubMed
  13. Arthritis Res Ther. 2009;11(3):R66 - PubMed
  14. Arthritis Res Ther. 2010;12(3):R80 - PubMed
  15. Nat Genet. 2010 Aug;42(8):703-6 - PubMed
  16. J Immunol. 2002 Jun 15;168(12):6208-14 - PubMed
  17. Tissue Antigens. 1999 Sep;54(3):213-20 - PubMed
  18. Hum Immunol. 2009 Jul;70(7):513-7 - PubMed
  19. Scand J Immunol. 2006 Jul;64(1):77-82 - PubMed
  20. Immunity. 2006 Mar;24(3):249-57 - PubMed
  21. Genes Immun. 2002 Sep;3(6):368-72 - PubMed
  22. J Immunol. 2011 Jul 1;187(1):11-9 - PubMed
  23. Nature. 2011 Oct 23;479(7373):401-5 - PubMed
  24. Blood. 2005 Oct 1;106(7):2252-8 - PubMed
  25. Immunogenetics. 2001 May-Jun;53(4):279-87 - PubMed
  26. Tissue Antigens. 2007 Feb;69(2):139-44 - PubMed
  27. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5199-204 - PubMed
  28. Blood. 2008 Aug 1;112(3):461-9 - PubMed
  29. Semin Immunol. 2006 Jun;18(3):145-50 - PubMed
  30. Int J Dermatol. 2003 Oct;42(10):803-6 - PubMed
  31. Hum Immunol. 2006 Nov;67(11):894-906 - PubMed
  32. J Exp Med. 1995 Mar 1;181(3):1133-44 - PubMed
  33. Rheumatology (Oxford). 2004 Apr;43(4):423-7 - PubMed
  34. Sci Transl Med. 2011 Dec 14;3(113):113ra124 - PubMed
  35. Nature. 2005 Aug 4;436(7051):709-13 - PubMed
  36. N Engl J Med. 1999 Oct 21;341(17):1284-91 - PubMed
  37. Rheumatol Int. 2004 Jul;24(4):212-6 - PubMed
  38. Nat Genet. 2013 Mar;45(3):319-24 - PubMed
  39. J Immunol. 2001 Jun 15;166(12):7260-7 - PubMed
  40. Tissue Antigens. 2011 Aug;78(2):81-8 - PubMed
  41. Hum Immunol. 2001 Jun;62(6):632-8 - PubMed
  42. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3053-8 - PubMed
  43. J Immunol. 1996 Oct 15;157(8):3350-6 - PubMed
  44. Nat Genet. 2013 Feb;45(2):202-7 - PubMed
  45. Tissue Antigens. 2005 Sep;66(3):195-9 - PubMed
  46. Cancer Res. 2006 Jan 1;66(1):563-70 - PubMed
  47. Hum Immunol. 2005 Oct;66(10):1057-61 - PubMed
  48. Hum Immunol. 2006 Mar;67(3):152-8 - PubMed
  49. Immunol Lett. 2008 Nov 16;121(1):7-12 - PubMed
  50. Hum Immunol. 1999 Jan;60(1):32-40 - PubMed
  51. Arthritis Res Ther. 2013 Oct 04;15(5):R145 - PubMed
  52. Nature. 2000 Jun 1;405(6786):537-43 - PubMed
  53. J Exp Med. 1996 Oct 1;184(4):1585-90 - PubMed
  54. Nature. 1986 Feb 20-26;319(6055):675-8 - PubMed
  55. Nat Genet. 2010 Aug;42(8):698-702 - PubMed
  56. Annu Rev Immunol. 1998;16:359-93 - PubMed
  57. Am J Ophthalmol. 2006 Sep;142(3):429-34 - PubMed
  58. Immunogenetics. 2001 Dec;53(9):724-8 - PubMed
  59. Clin Exp Rheumatol. 2011 Jul-Aug;29(4 Suppl 67):S3-5 - PubMed
  60. Tissue Antigens. 2007 Nov;70(5):435-8 - PubMed
  61. Rheumatology (Oxford). 2004 Oct;43(10 ):1275-82 - PubMed
  62. Arthritis Rheum. 2005 Jun;52(6):1836-42 - PubMed
  63. Ocul Immunol Inflamm. 2013 Apr;21(2):135-43 - PubMed
  64. J Immunol. 2001 Aug 15;167(4):1877-81 - PubMed
  65. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1298-303 - PubMed
  66. Nat Immunol. 2004 Oct;5(10):996-1002 - PubMed
  67. Multidiscip Respir Med. 2013 Apr 04;8(1):29 - PubMed
  68. Jpn J Ophthalmol. 2007 Nov-Dec;51(6):431-6 - PubMed
  69. Invest Ophthalmol Vis Sci. 1999 Aug;40(9):1921-6 - PubMed
  70. Tissue Antigens. 2007 Oct;70(4):307-13 - PubMed
  71. J Immunol. 1998 Jul 15;161(2):571-7 - PubMed
  72. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):728-32 - PubMed

Publication Types