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Sunwoo YY, Lee JH, Jung HY, et al. Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evid Based Complement Alternat Med. 2015;2015:501508doi: 10.1155/2015/501508.
Sunwoo, Y. Y., Lee, J. H., Jung, H. Y., Jung, Y. J., Park, M. S., Chung, Y. A., Maeng, L. S., Han, Y. M., Shin, H. S., Lee, J., & Park, S. I. (2015). Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evidence-based complementary and alternative medicine : eCAM, 2015501508. https://doi.org/10.1155/2015/501508
Sunwoo, Yun-Young, et al. "Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 501508. doi: https://doi.org/10.1155/2015/501508
Sunwoo YY, Lee JH, Jung HY, Jung YJ, Park MS, Chung YA, Maeng LS, Han YM, Shin HS, Lee J, Park SI. Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Evid Based Complement Alternat Med. 2015;2015:501508. doi: 10.1155/2015/501508. Epub 2015 Mar 10. PMID: 25852766; PMCID: PMC4379430.
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Evid Based Complement Alternat Med. 2015;2015:501508. doi: 10.1155/2015/501508. Epub 2015 Mar 10.

Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis.

Evidence-based complementary and alternative medicine : eCAM

Yun-Young Sunwoo, Jin-Hee Lee, Ho Yong Jung, Yu Jin Jung, Moon-Seo Park, Yong-An Chung, Lee-So Maeng, Young-Min Han, Hak Soo Shin, Jisoo Lee, Sang In Park

Affiliations

  1. Comprehensive Hospital for Advanced Cancer, International St. Mary's Hospital, College of Medicine, The Catholic Kwandong University of Korea, Incheon 404-834, Republic of Korea.
  2. Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
  3. Institute of Catholic Integrative Medicine (ICIM), Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon 403-720, Republic of Korea.
  4. EIT/LOFUS Research Center, International St. Mary's Hospital, College of Medicine, The Catholic Kwandong University of Korea, Incheon 404-834, Republic of Korea.
  5. Institute of Catholic Integrative Medicine (ICIM), Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon 403-720, Republic of Korea ; Department of Radiology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon 403-720, Republic of Korea.
  6. Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.

PMID: 25852766 PMCID: PMC4379430 DOI: 10.1155/2015/501508

Abstract

Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease. Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). Here, we show that the therapeutic effect of OD, which was investigated both in vitro and chemically, induced HCC model. OD significantly enhanced apoptosis and antiproliferative activity and reduced migration ability of HCC cells. In vivo, OD was treated twice a day for 28 days after confirmed HCC model through 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) imaging. The survival in OD treated groups was shown to have a greater therapeutic effect than the control group. 28 days after OD treatment, OD treated groups resulted in a significant reduction in tumor number, size, (18)F-FDG uptake, and serum levels such as alanine transaminase, aspartate transaminase, and alkaline phosphate compared to the control group. Also, proliferated cells in tumor sites by OD were reduced compared to the control group. Furthermore, several rats in OD treated group survived over 60 days and liver morphology of these rats showed the difference between tumor mass and normal tissue. These results suggest that OD may have antiproliferative activity, inhibition of metastasis, and apoptotic effects in chemically induced HCC model and can have the potential use for clinical application as anticancer drug of the herbal extract.

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