Display options
Cite
Kuzu UB, Ödemiş B, Turhan N, et al. The diagnostic value of brush cytology alone and in combination with tumor markers in pancreaticobiliary strictures. Gastroenterol Res Pract. 2015;2015:580254doi: 10.1155/2015/580254.
Kuzu, U. B., Ödemiş, B., Turhan, N., Parlak, E., Dişibeyaz, S., Suna, N., Öztaş, E., Akpınar, M. Y., Aksoy, A., Torun, S., Yıldız, H., & Kayaçetin, E. (2015). The diagnostic value of brush cytology alone and in combination with tumor markers in pancreaticobiliary strictures. Gastroenterology research and practice, 2015580254. https://doi.org/10.1155/2015/580254
Kuzu, Ufuk Barış, et al. "The diagnostic value of brush cytology alone and in combination with tumor markers in pancreaticobiliary strictures." Gastroenterology research and practice vol. 2015 (2015): 580254. doi: https://doi.org/10.1155/2015/580254
Kuzu UB, Ödemiş B, Turhan N, Parlak E, Dişibeyaz S, Suna N, Öztaş E, Akpınar MY, Aksoy A, Torun S, Yıldız H, Kayaçetin E. The diagnostic value of brush cytology alone and in combination with tumor markers in pancreaticobiliary strictures. Gastroenterol Res Pract. 2015;2015:580254. doi: 10.1155/2015/580254. Epub 2015 Mar 26. PMID: 25883643; PMCID: PMC4391493.
Copy Download .nbib Format: NLM
Share it on

Gastroenterol Res Pract. 2015;2015:580254. doi: 10.1155/2015/580254. Epub 2015 Mar 26.

The diagnostic value of brush cytology alone and in combination with tumor markers in pancreaticobiliary strictures.

Gastroenterology research and practice

Ufuk Barış Kuzu, Bülent Ödemiş, Nesrin Turhan, Erkan Parlak, Selçuk Dişibeyaz, Nuretdin Suna, Erkin Öztaş, Muhammet Yener Akpınar, Adem Aksoy, Serkan Torun, Hakan Yıldız, Ertuğrul Kayaçetin

Affiliations

  1. Department of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, Turkey.
  2. Department of Pathology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, Turkey.

PMID: 25883643 PMCID: PMC4391493 DOI: 10.1155/2015/580254

Abstract

Aim. Differentiation of malignant and benign strictures constitutes a problem despite the increasing experience of the endoscopists, radiologists, and pathologists. The aim of our study is to determine the factors that affect the efficacy of the ERCP guided brush cytology in PBS and to evaluate its diagnostic success when used alone and together with tumor markers. Method. The data from brush cytologies of 301 PBS patients were collected retrospectively and analyzed. The final diagnosis was approved based on the histological examination of the tissue taken surgically or by other methods. In the absence of a histological diagnosis, the final diagnosis was based on radiological studies or the results of a 12-month clinical follow up. Results. A total of 28 patients were excluded from the study. From the remaining 273 patients 299 samples were analyzed. The sensitivity and the specificity of brush cytology in diagnosing malignancy are 62.4% and 97.7, respectively. The sensitivity of brush cytology increased to 94.1% when combined with CA-19.9 and CA-125. Conclusion. Brush cytology is a useful method in diagnosing pancreaticobiliary strictures. Advanced age, stricture dilatation before sampling, the presence of a mass identified by radiological studies, high levels of CA-19.9, ALT, and total bilirubin increase the sensitivity of brush cytology.

References

  1. Gastrointest Endosc. 2006 May;63(6):741-5 - PubMed
  2. Am J Surg. 1991 Jan;161(1):26-9; discussion 29-30 - PubMed
  3. Gastrointest Endosc. 1998 Sep;48(3):288-90 - PubMed
  4. Br J Surg. 1993 Apr;80(4):414-21 - PubMed
  5. Gastrointest Endosc. 2001 Nov;54(5):587-94 - PubMed
  6. Hepatogastroenterology. 2002 May-Jun;49(45):616-20 - PubMed
  7. Acta Gastroenterol Belg. 2000 Jul-Sep;63(3):254-9 - PubMed
  8. Gastrointest Endosc. 1994 Mar-Apr;40(2 Pt 1):249-52 - PubMed
  9. Clin Cancer Res. 1999 Mar;5(3):629-35 - PubMed
  10. Dan Med J. 2013 Jul;60(7):A4656 - PubMed
  11. Diagn Cytopathol. 2000 Nov;23(5):308-13 - PubMed
  12. Pancreas. 2011 Jan;40(1):52-4 - PubMed
  13. Rev Esp Enferm Dig. 2009 Jun;101(6):385-9, 390-4 - PubMed
  14. Arch Surg. 2006 Oct;141(10):968-73; discussion 974 - PubMed
  15. Int J Gynecol Pathol. 1983;2(3):275-85 - PubMed
  16. Gastrointest Endosc. 1984 Jun;30(3):163-6 - PubMed
  17. Eur J Intern Med. 2002 Mar;13(2):132-135 - PubMed
  18. Dig Dis Sci. 2005 Sep;50(9):1734-40 - PubMed
  19. J Surg Oncol. 2007 Feb 1;95(2):142-7 - PubMed
  20. Acta Cytol. 2000 Jul-Aug;44(4):533-8 - PubMed
  21. Gastrointest Endosc. 2002 Nov;56(5):720-30 - PubMed
  22. Scand J Gastroenterol. 1975;10(8):829-31 - PubMed
  23. Gastrointest Endosc. 1994 Mar-Apr;40(2 Pt 1):150-4 - PubMed
  24. Acta Cytol. 1990 Mar-Apr;34(2):221-6 - PubMed
  25. Diagn Cytopathol. 1997 Apr;16(4):358-63 - PubMed
  26. Gut. 1991 Oct;32(10):1188-91 - PubMed
  27. Gastroenterologist. 1997 Dec;5(4):306-15 - PubMed
  28. J Gastroenterol Hepatol. 2011 Aug;26(8):1247-51 - PubMed
  29. J Clin Gastroenterol. 1995 Jul;21(1):48-60 - PubMed
  30. Am J Gastroenterol. 1995 May;90(5):722-6 - PubMed
  31. Hepatobiliary Pancreat Dis Int. 2009 Dec;8(6):620-6 - PubMed
  32. World J Gastroenterol. 2008 Jan 28;14(4):569-73 - PubMed
  33. Gastrointest Endosc. 2002 Oct;56(4):552-61 - PubMed
  34. Endoscopy. 1999 Nov;31(9):712-7 - PubMed
  35. Gastrointest Endosc. 2003 Aug;58(2):176-82 - PubMed
  36. Am J Clin Pathol. 1998 May;109(5):540-8 - PubMed
  37. J Clin Pathol. 2001 Jun;54(6):449-55 - PubMed
  38. Cancer. 2006 Aug 25;108(4):231-8 - PubMed
  39. Gut. 1992 Dec;33(12):1675-7 - PubMed
  40. Rev Esp Enferm Dig. 2008 Aug;100(8):462-5 - PubMed
  41. Dig Liver Dis. 2009 Aug;41(8):605-8 - PubMed
  42. Endoscopy. 2002 Nov;34(11):909-16 - PubMed
  43. Br J Cancer. 1986 Dec;54(6):897-901 - PubMed
  44. Gastrointest Endosc. 1996 Sep;44(3):300-4 - PubMed
  45. Gastrointest Endosc. 1995 Dec;42(6):565-72 - PubMed
  46. Acta Cytol. 1995 Jan-Feb;39(1):11-8 - PubMed
  47. Arch Pathol Lab Med. 2000 Mar;124(3):387-92 - PubMed
  48. Hepatogastroenterology. 1997 Jul-Aug;44(16):1117-21 - PubMed

Publication Types