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Schalla S, Jaarsma C, Bekkers SC, et al. Right ventricular function in dilated cardiomyopathy and ischemic heart disease: assessment with non-invasive imaging. Neth Heart J. 2015;23(4):232-40doi: 10.1007/s12471-015-0673-x.
Schalla, S., Jaarsma, C., Bekkers, S. C., Waltenberger, J., Dennert, R., Crijns, H. J., Wildberger, J., Heymans, S., & Brunner-La Rocca, H. P. (2015). Right ventricular function in dilated cardiomyopathy and ischemic heart disease: assessment with non-invasive imaging. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 23(4), 232-40. https://doi.org/10.1007/s12471-015-0673-x
Schalla, S, et al. "Right ventricular function in dilated cardiomyopathy and ischemic heart disease: assessment with non-invasive imaging." Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation vol. 23,4 (2015): 232-40. doi: https://doi.org/10.1007/s12471-015-0673-x
Schalla S, Jaarsma C, Bekkers SC, Waltenberger J, Dennert R, Crijns HJ, Wildberger J, Heymans S, Brunner-La Rocca HP. Right ventricular function in dilated cardiomyopathy and ischemic heart disease: assessment with non-invasive imaging. Neth Heart J. 2015 Apr;23(4):232-40. doi: 10.1007/s12471-015-0673-x. PMID: 25884096; PMCID: PMC4368531.
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Neth Heart J. 2015 Apr;23(4):232-40. doi: 10.1007/s12471-015-0673-x.

Right ventricular function in dilated cardiomyopathy and ischemic heart disease: assessment with non-invasive imaging.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

S Schalla, C Jaarsma, S C Bekkers, J Waltenberger, R Dennert, H J Crijns, J Wildberger, S Heymans, H-P Brunner-La Rocca

Affiliations

  1. Department of Cardiology, Maastricht University Medical Center, P. Debyelaan 25, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands, [email protected].

PMID: 25884096 PMCID: PMC4368531 DOI: 10.1007/s12471-015-0673-x

Abstract

BACKGROUND: Dilated cardiomyopathy and ischaemic heart disease can both lead to right ventricular (RV) dysfunction. Direct comparisons of the two entities regarding RV size and function using state-of-the-art imaging techniques have not yet been performed. We aimed to determine RV function and volume in dilated cardiomyopathy and ischaemic heart disease in relation to left ventricular (LV) systolic and diastolic function and systolic pulmonary artery pressure.

METHODS AND RESULTS: A well-characterised group (cardiac magnetic resonance imaging, echocardiography, coronary angiography and endomyocardial biopsy) of 46 patients with dilated cardiomyopathy was compared with LV ejection fraction (EF)-matched patients (n = 23) with ischaemic heart disease. Volumes and EF were determined with magnetic resonance imaging, diastolic LV function and pulmonary artery pressure with echocardiography. After multivariable linear regression, four factors independently influenced RVEF (R(2) = 0.51, p < 0.001): LVEF (r = 0.54, p < 0.001), ratio of peak early and peak atrial transmitral Doppler flow velocity as measure of LV filling pressure (r = - 0.52, p < 0.001) and tricuspid regurgitation flow velocity as measure of pulmonary artery pressure (r = - 0.38, p = 0.001). RVEF was significantly worse in patients with dilated cardiomyopathy compared with ischaemic heart disease: median 48 % (interquartile range (IQR) 37-55 %) versus 56 % (IQR 48-63 %), p < 0.05.

CONCLUSIONS: In patients with dilated cardiomyopathy and ischaemic heart disease, RV function is determined by LV systolic and diastolic function, the underlying cause of LV dysfunction, and pulmonary artery pressure. It was demonstrated that RV function is more impaired in dilated cardiomyopathy.

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