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Das P, Omollo AO, Sitole LJ, et al. Synthesis and Investigation of Novel Spiro-isoxazolines as Anti-Cancer Agents. Tetrahedron Lett. 2015;56(14):1794-1797doi: 10.1016/j.tetlet.2015.02.059.
Das, P., Omollo, A. O., Sitole, L. J., McClendon, E., Valente, E. J., Raucher, D., Walker, L. R., & Hamme, A. T. (2015). Synthesis and Investigation of Novel Spiro-isoxazolines as Anti-Cancer Agents. Tetrahedron letters, 56(14), 1794-1797. https://doi.org/10.1016/j.tetlet.2015.02.059
Das, Prasanta, et al. "Synthesis and Investigation of Novel Spiro-isoxazolines as Anti-Cancer Agents." Tetrahedron letters vol. 56,14 (2015): 1794-1797. doi: https://doi.org/10.1016/j.tetlet.2015.02.059
Das P, Omollo AO, Sitole LJ, McClendon E, Valente EJ, Raucher D, Walker LR, Hamme AT. Synthesis and Investigation of Novel Spiro-isoxazolines as Anti-Cancer Agents. Tetrahedron Lett. 2015 Apr 01;56(14):1794-1797. doi: 10.1016/j.tetlet.2015.02.059. PMID: 25821250; PMCID: PMC4371604.
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Tetrahedron Lett. 2015 Apr 01;56(14):1794-1797. doi: 10.1016/j.tetlet.2015.02.059.

Synthesis and Investigation of Novel Spiro-isoxazolines as Anti-Cancer Agents.

Tetrahedron letters

Prasanta Das, Ann O Omollo, Lungile J Sitole, Eric McClendon, Edward J Valente, Drazen Raucher, Leslie R Walker, Ashton T Hamme

Affiliations

  1. Department of Chemistry & Biochemistry, Jackson State University 1400 J. R. Lynch St, PO Box 17910, Jackson, Ms 39217, USA.
  2. Department of Chemistry, University of Portland, Portland, OR 97203, USA.
  3. Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, 39216, USA.

PMID: 25821250 PMCID: PMC4371604 DOI: 10.1016/j.tetlet.2015.02.059

Abstract

A series of structurally diverse 4-bromo spiro-isoxazolines possessing a variety of aromatic and aliphatic substituents at the 3 position, were synthesized through a 1,3-dipolar cycloaddition followed by intramolecular cyclization of a pendant hydroxyl or carboxylic acid group. The biochemical antiproliferative activity was evaluated

Keywords: 1,3-dipolar Cycloaddition; Bioevaluation; Regioselectivity; Spiro-isoxazolines; Stereoselective Intramolecular Cyclization

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