Display options
Cite
Ben M'Barek K, Regent F, Monville C. Use of human pluripotent stem cells to study and treat retinopathies. World J Stem Cells. 2015;7(3):596-604doi: 10.4252/wjsc.v7.i3.596.
Ben M'Barek, K., Regent, F., & Monville, C. (2015). Use of human pluripotent stem cells to study and treat retinopathies. World journal of stem cells, 7(3), 596-604. https://doi.org/10.4252/wjsc.v7.i3.596
Ben M'Barek, Karim, et al. "Use of human pluripotent stem cells to study and treat retinopathies." World journal of stem cells vol. 7,3 (2015): 596-604. doi: https://doi.org/10.4252/wjsc.v7.i3.596
Ben M'Barek K, Regent F, Monville C. Use of human pluripotent stem cells to study and treat retinopathies. World J Stem Cells. 2015 Apr 26;7(3):596-604. doi: 10.4252/wjsc.v7.i3.596. PMID: 25914766; PMCID: PMC4404394.
Copy Download .nbib Format: NLM
Share it on

World J Stem Cells. 2015 Apr 26;7(3):596-604. doi: 10.4252/wjsc.v7.i3.596.

Use of human pluripotent stem cells to study and treat retinopathies.

World journal of stem cells

Karim Ben M'Barek, Florian Regent, Christelle Monville

Affiliations

  1. Karim Ben M'Barek, Florian Regent, Christelle Monville, INSERM UMR861, I-Stem, AFM, Genopole Campus 1, 91030 Evry, France.

PMID: 25914766 PMCID: PMC4404394 DOI: 10.4252/wjsc.v7.i3.596

Abstract

Human cell types affected by retinal diseases (such as age-related macular degeneration or retinitis pimentosa) are limited in cell number and of reduced accessibility. As a consequence, their isolation for in vitro studies of disease mechanisms or for drug screening efforts is fastidious. Human pluripotent stem cells (hPSCs), either of embryonic origin or through reprogramming of adult somatic cells, represent a new promising way to generate models of human retinopathies, explore the physiopathological mechanisms and develop novel therapeutic strategies. Disease-specific human embryonic stem cells were the first source of material to be used to study certain disease states. The recent demonstration that human somatic cells, such as fibroblasts or blood cells, can be genetically converted to induce pluripotent stem cells together with the continuous improvement of methods to differentiate these cells into disease-affected cellular subtypes opens new perspectives to model and understand a large number of human pathologies, including retinopathies. This review focuses on the added value of hPSCs for the disease modeling of human retinopathies and the study of their molecular pathological mechanisms. We also discuss the recent use of these cells for establishing the validation studies for therapeutic intervention and for the screening of large compound libraries to identify candidate drugs.

Keywords: Disease modeling; Drug screening; Human pluripotent stem cells; Retinitis pigmentosa

References

  1. Stem Cells. 2011 Aug;29(8):1206-18 - PubMed
  2. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 2:1101-13 - PubMed
  3. Methods Mol Biol. 2010;636:191-205 - PubMed
  4. Exp Neurol. 2007 May;205(1):20-5 - PubMed
  5. Arch Ophthalmol. 2004 Apr;122(4):598-614 - PubMed
  6. J Biol Chem. 2014 Mar 7;289(10):6362-71 - PubMed
  7. Genet Mol Biol. 2012 Jul;35(3):693-700 - PubMed
  8. Stem Cells. 2012 Aug;30(8):1696-702 - PubMed
  9. BMJ. 2007 Jan 27;334(7586):197 - PubMed
  10. Cell Res. 2008 May;18(5):600-3 - PubMed
  11. Ophthalmic Genet. 1994 Jun;15(2):61-7 - PubMed
  12. Nat Biotechnol. 2009 May;27(5):459-61 - PubMed
  13. PLoS One. 2012;7(4):e35318 - PubMed
  14. Nature. 2012 May 3;485(7396):99-103 - PubMed
  15. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5901-8 - PubMed
  16. Stem Cells. 2013 Feb;31(2):408-14 - PubMed
  17. Nat Biotechnol. 2014 Mar;32(3):279-84 - PubMed
  18. Nat Biotechnol. 2011 Jul 07;29(8):731-4 - PubMed
  19. Cell Stem Cell. 2012 Jun 14;10(6):771-85 - PubMed
  20. Nat Biotechnol. 2013 Mar;31(3):230-2 - PubMed
  21. N Engl J Med. 2008 Jun 12;358(24):2606-17 - PubMed
  22. Bioessays. 2012 Jan;34(1):61-71 - PubMed
  23. Nature. 2006 Nov 9;444(7116):203-7 - PubMed
  24. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12769-74 - PubMed
  25. Nat Med. 2011 Dec;17(12):1570-6 - PubMed
  26. Invest Ophthalmol Vis Sci. 2013 Oct 17;54(10):6767-78 - PubMed
  27. Stem Cells Transl Med. 2013 Apr;2(4):255-64 - PubMed
  28. PLoS One. 2010 Jan 20;5(1):e8763 - PubMed
  29. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E569-76 - PubMed
  30. Tissue Eng Part B Rev. 2011 Apr;17(2):115-24 - PubMed
  31. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23 ):8518-23 - PubMed
  32. Clin Pharmacol Ther. 2011 May;89(5):655-61 - PubMed
  33. PLoS One. 2011 Mar 11;6(3):e17610 - PubMed
  34. Mamm Genome. 2007 Jul;18(6-7):444-51 - PubMed
  35. Nat Rev Genet. 2005 Jun;6(6):507-12 - PubMed
  36. Development. 2012 Nov;139(22):4111-21 - PubMed
  37. Mol Vis. 2009;15:283-95 - PubMed
  38. Science. 1998 Nov 6;282(5391):1145-7 - PubMed
  39. Blood. 2013 Apr 11;121(15):2882-90 - PubMed
  40. Nat Genet. 1997 Oct;17(2):139-41 - PubMed
  41. PLoS One. 2011 Feb 10;6(2):e17084 - PubMed
  42. Stem Cells. 2013 Mar;31(3):458-66 - PubMed
  43. Hum Mol Genet. 2010 Nov 1;19(21):4229-38 - PubMed
  44. Stem Cells Dev. 2013 Aug 15;22(16):2268-77 - PubMed
  45. Nat Commun. 2012;3:1085 - PubMed
  46. Nat Biotechnol. 2008 Feb;26(2):215-24 - PubMed
  47. J Comp Neurol. 1979 Nov 15;188(2):263-72 - PubMed
  48. Cell Stem Cell. 2012 Aug 3;11(2):153-61 - PubMed
  49. Stem Cells. 2013 Sep;31(9):1816-28 - PubMed
  50. Prog Brain Res. 2012;201:171-81 - PubMed
  51. J Cell Physiol. 2012 Feb;227(2):457-66 - PubMed
  52. Hum Mol Genet. 2013 Feb 1;22(3):558-67 - PubMed
  53. Hum Gene Ther Clin Dev. 2013 Mar;24(1):23-8 - PubMed
  54. Mol Ther. 2011 Apr;19(4):642-9 - PubMed
  55. Nat Rev Genet. 2010 Sep;11(9):636-46 - PubMed
  56. Tissue Eng Part A. 2014 May;20(9-10):1465-75 - PubMed
  57. Nat Protoc. 2009;4(6):811-24 - PubMed
  58. Vision Res. 2008 Feb;48(3):433-41 - PubMed
  59. Am J Ophthalmol. 2013 Sep;156(3):433-7.e3 - PubMed
  60. Hum Gene Ther. 2009 Apr;20(4):291-2 - PubMed
  61. Mol Plant. 2014 May;7(5):923-6 - PubMed
  62. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4335-40 - PubMed
  63. Science. 2007 Dec 21;318(5858):1917-20 - PubMed
  64. Stem Cells. 2014 Jun;32(6):1480-92 - PubMed
  65. Cell Reprogram. 2013 Jun;15(3):233-46 - PubMed
  66. Nat Rev Mol Cell Biol. 2013 Jan;14(1):49-55 - PubMed
  67. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E517-25 - PubMed
  68. Curr Opin Cell Biol. 2012 Dec;24(6):744-56 - PubMed
  69. Adv Exp Med Biol. 2012;723:199-205 - PubMed
  70. Stem Cell Reports. 2014 May 22;2(6):853-65 - PubMed
  71. Neurosci Lett. 2009 Jul 24;458(3):126-31 - PubMed
  72. Invest Ophthalmol Vis Sci. 2013 Sep 11;54(9):6118-32 - PubMed
  73. Nat Methods. 2013 Oct;10(10):977-9 - PubMed
  74. Cell Stem Cell. 2013 Feb 7;12(2):238-51 - PubMed
  75. Cell Stem Cell. 2014 Aug 7;15(2):215-26 - PubMed
  76. Stem Cells Transl Med. 2013 Jan;2(1):16-24 - PubMed
  77. Exp Eye Res. 2009 Sep;89(3):301-10 - PubMed
  78. Scand J Med Sci Sports. 2014 Apr;24(2):336-44 - PubMed
  79. Stem Cells. 2012 Apr;30(4):673-86 - PubMed
  80. J Biosci. 2013 Mar;38(1):123-34 - PubMed
  81. Stem Cells Dev. 2014 May 1;23(9):941-54 - PubMed
  82. Adv Exp Med Biol. 2014;801:711-8 - PubMed
  83. N Engl J Med. 2006 Oct 5;355(14):1474-85 - PubMed
  84. Nat Biotechnol. 2008 Nov;26(11):1276-84 - PubMed
  85. Acta Neurobiol Exp (Wars). 2011;71(1):86-93 - PubMed
  86. Science. 2013 Feb 15;339(6121):819-23 - PubMed
  87. Cell. 1986 Feb 14;44(3):419-28 - PubMed
  88. Nat Biotechnol. 2013 Jun;31(6):530-2 - PubMed
  89. Hum Mol Genet. 1997 Jun;6(6):851-8 - PubMed
  90. Cell. 2007 Nov 30;131(5):861-72 - PubMed
  91. Science. 2013 Feb 15;339(6121):823-6 - PubMed
  92. Mol Brain. 2014 Jun 16;7:45 - PubMed
  93. Exp Eye Res. 2008 Apr;86(4):691-700 - PubMed
  94. BMC Cell Biol. 2012 Mar 26;13:9 - PubMed
  95. Int J Mol Sci. 2014 Aug 20;15(8):14456-74 - PubMed
  96. Stem Cells Transl Med. 2014 Aug;3(8):911-22 - PubMed
  97. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3612-24 - PubMed
  98. Methods Mol Biol. 2014;1114:245-67 - PubMed
  99. Invest Ophthalmol Vis Sci. 2012 Apr 18;53(4):2007-19 - PubMed
  100. J Mol Cell Biol. 2011 Apr;3(2):91-8 - PubMed
  101. Cold Spring Harb Symp Quant Biol. 2010;75:201-9 - PubMed
  102. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16698-703 - PubMed
  103. Curr Mol Med. 2010 Dec;10(9):802-23 - PubMed

Publication Types