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Kishi T, Hirooka Y, Sunagawa K. Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats. Int J Hypertens. 2015;2015:759629doi: 10.1155/2015/759629.
Kishi, T., Hirooka, Y., & Sunagawa, K. (2015). Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats. International journal of hypertension, 2015759629. https://doi.org/10.1155/2015/759629
Kishi, Takuya, et al. "Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats." International journal of hypertension vol. 2015 (2015): 759629. doi: https://doi.org/10.1155/2015/759629
Kishi T, Hirooka Y, Sunagawa K. Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats. Int J Hypertens. 2015;2015:759629. doi: 10.1155/2015/759629. Epub 2015 Mar 30. PMID: 25918643; PMCID: PMC4396736.
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Int J Hypertens. 2015;2015:759629. doi: 10.1155/2015/759629. Epub 2015 Mar 30.

Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats.

International journal of hypertension

Takuya Kishi, Yoshitaka Hirooka, Kenji Sunagawa

Affiliations

  1. Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
  2. Department of Advanced Cardiovascular Regulation and Therapeutics, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
  3. Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

PMID: 25918643 PMCID: PMC4396736 DOI: 10.1155/2015/759629

Abstract

Abnormal blood pressure (BP) elevation in early morning is known to cause cardiovascular events. Previous studies have suggested that one of the reasons in abnormal dairy BP variability is sympathoexcitation. We have demonstrated that brain angiotensin II type 1 receptor (AT1R) causes sympathoexcitation. The aim of the present study was to investigate whether central AT1R blockade attenuates the excess BP elevation in rest-to-active phase in hypertensive rats or not. Stroke-prone spontaneously hypertensive rats (SHRSP) were treated with intracerebroventricular infusion (ICV) of AT1R receptor blocker (ARB), oral administration of hydralazine (HYD), or ICV of vehicle (VEH). Telemetric averaged mean BP (MBP) was measured at early morning (EM), after morning (AM), and night (NT). At EM, MBP was significantly lower in ARB to a greater extent than in HYD compared to VEH, though MBP at AM was the same in ARB and HYD. At NT, MBP was also significantly lower in ARB than in HYD. These results in MBP were compatible to those in sympathoexcitation and suggest that central AT1R blockade attenuates excess BP elevation in early active phase and continuous BP elevation during rest phase independent of depressor response in hypertensive rats.

References

  1. J Hypertens. 2003 Jun;21(6):1107-15 - PubMed
  2. Circulation. 2004 May 18;109(19):2357-62 - PubMed
  3. Hypertens Res. 2009 Dec;32(12):1047-8 - PubMed
  4. Lancet. 2001 Oct 20;358(9290):1305-15 - PubMed
  5. Hypertension. 2009 Oct;54(4):690-7 - PubMed
  6. Nat Rev Neurosci. 2006 May;7(5):335-46 - PubMed
  7. Hypertension. 2002 Dec;40(6):827-33 - PubMed
  8. Hypertens Res. 2010 Oct;33(10):1060-5 - PubMed
  9. Am J Physiol. 1991 Oct;261(4 Pt 2):H1292-9 - PubMed
  10. Clin Exp Hypertens. 2008 Jan;30(1):3-11 - PubMed
  11. J Hypertens. 2010 Jul;28(7):1438-48 - PubMed
  12. Hypertension. 2010 Apr;55(4):835-7 - PubMed
  13. Acta Pharmacol Sin. 2007 Apr;28(4):484-92 - PubMed
  14. Curr Hypertens Rep. 2006 Jun;8(3):232-41 - PubMed
  15. Hypertension. 2010 Nov;56(5):765-73 - PubMed
  16. J Hypertens. 2007 Jun;25(6):1105-87 - PubMed
  17. Circulation. 2003 Mar 18;107(10):1401-6 - PubMed
  18. Hypertens Res. 2009 Jan;32(1):3-107 - PubMed
  19. Hypertension. 2010 Feb;55(2):291-7 - PubMed
  20. Clin Exp Hypertens. 2009 Nov;31(8):625-38 - PubMed
  21. J Mol Cell Cardiol. 2007 Oct;43(4):479-86 - PubMed
  22. Neurosci Lett. 2004 Apr 1;358(3):165-8 - PubMed
  23. J Am Soc Hypertens. 2008 Nov-Dec;2(6):397-402 - PubMed
  24. Physiol Rev. 1994 Apr;74(2):323-64 - PubMed
  25. Free Radic Biol Med. 2005 Feb 15;38(4):450-62 - PubMed
  26. Int Heart J. 2012;53(3):193-8 - PubMed
  27. Hypertens Res. 2012 Sep;35(9):940-6 - PubMed
  28. Hypertens Res. 2006 Aug;29(8):581-7 - PubMed

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