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Jung HS, Moon SJ, Kim YM, et al. False Positive Radioiodinated Metaiodobenzylguanidine ((123)I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor. Case Rep Oncol Med. 2015;2015:164280doi: 10.1155/2015/164280.
Jung, H. S., Moon, S. J., Kim, Y. M., Kang, H. R., Lee, S. M., Jung, S. J., Choi, S. J., Kim, T. K., Kwon, M. J., Park, J. H., & Lee, S. H. (2015). False Positive Radioiodinated Metaiodobenzylguanidine ((123)I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor. Case reports in oncological medicine, 2015164280. https://doi.org/10.1155/2015/164280
Jung, Hee Soo, et al. "False Positive Radioiodinated Metaiodobenzylguanidine ((123)I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor." Case reports in oncological medicine vol. 2015 (2015): 164280. doi: https://doi.org/10.1155/2015/164280
Jung HS, Moon SJ, Kim YM, Kang HR, Lee SM, Jung SJ, Choi SJ, Kim TK, Kwon MJ, Park JH, Lee SH. False Positive Radioiodinated Metaiodobenzylguanidine ((123)I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor. Case Rep Oncol Med. 2015;2015:164280. doi: 10.1155/2015/164280. Epub 2015 Mar 30. PMID: 25918656; PMCID: PMC4396541.
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Case Rep Oncol Med. 2015;2015:164280. doi: 10.1155/2015/164280. Epub 2015 Mar 30.

False Positive Radioiodinated Metaiodobenzylguanidine ((123)I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor.

Case reports in oncological medicine

Hee Soo Jung, Seok Jun Moon, Yun Mi Kim, Hye Rim Kang, Seok Mo Lee, Soo Jin Jung, Seok Jin Choi, Tae Kyoon Kim, Min Jeong Kwon, Jeong Hyun Park, Soon Hee Lee

Affiliations

  1. Department of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
  2. Department of Nuclear Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
  3. Department of Pathology, Busan Paik Hospital, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
  4. Department of Radiology, Busan Paik Hospital, College of Medicine, Inje University, Busan 614-735, Republic of Korea.
  5. Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea.

PMID: 25918656 PMCID: PMC4396541 DOI: 10.1155/2015/164280

Abstract

(123)I-Metaiodobenzylguanidine ((123)I-MIBG) scintigraphy is a widely used functional imaging tool with a high degree of sensitivity and specificity in diagnosis of pheochromocytoma. However, rare cases of false positive reactions have been reported. A 67-year-old male patient was admitted with epigastric pain. Abdominal computed tomography (CT) revealed a heterogeneous left adrenal mass 6 cm in diameter; following hormone testing, (123)I-MIBG scintigraphy was performed to determine the presence of pheochromocytoma, which confirmed eccentric uptake by a large left adrenal gland mass. Chest CT and PET-CT confirmed metastatic lymphadenopathy; therefore, endobronchial ultrasound transbronchial needle aspiration was performed. Metastatic carcinoma of unknown origin was suspected from a lymph node biopsy, and surgical resection was performed for definitive diagnosis and correction of excess hormonal secretion. A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of (123)I-MIBG demonstrated by scintigraphy.

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