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Di Maso V, Carraro M, Bevilacqua E, et al. Warfarin-related nephropathy: possible role for the warfarin pharmacogenetic profile. Clin Kidney J. 2014;7(6):605-8doi: 10.1093/ckj/sfu112.
Di Maso, V., Carraro, M., Bevilacqua, E., Bucconi, S., Artero, M. L., & Boscutti, G. (2014). Warfarin-related nephropathy: possible role for the warfarin pharmacogenetic profile. Clinical kidney journal, 7(6), 605-8. https://doi.org/10.1093/ckj/sfu112
Di Maso, Vittorio, et al. "Warfarin-related nephropathy: possible role for the warfarin pharmacogenetic profile." Clinical kidney journal vol. 7,6 (2014): 605-8. doi: https://doi.org/10.1093/ckj/sfu112
Di Maso V, Carraro M, Bevilacqua E, Bucconi S, Artero ML, Boscutti G. Warfarin-related nephropathy: possible role for the warfarin pharmacogenetic profile. Clin Kidney J. 2014 Dec;7(6):605-8. doi: 10.1093/ckj/sfu112. Epub 2014 Oct 28. PMID: 25859382; PMCID: PMC4389147.
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Clin Kidney J. 2014 Dec;7(6):605-8. doi: 10.1093/ckj/sfu112. Epub 2014 Oct 28.

Warfarin-related nephropathy: possible role for the warfarin pharmacogenetic profile.

Clinical kidney journal

Vittorio Di Maso, Michele Carraro, Elena Bevilacqua, Sergio Bucconi, Mary Louise Artero, Giuliano Boscutti

Affiliations

  1. Nephrology and Dialysis Department , AOTS Trieste Hospital , Trieste , Italy.
  2. Nephrology and Dialysis Department , AOTS Trieste Hospital , Trieste , Italy ; Department of Medical Sciences , University of Trieste , Trieste , Italy.
  3. Transfusion Medicine Department Tissue Typing Laboratory , AOTS Trieste Hospital , Trieste , Italy.
  4. Anatomical Pathology Department , AOTS Trieste Hospital , Trieste , Italy.

PMID: 25859382 PMCID: PMC4389147 DOI: 10.1093/ckj/sfu112

Abstract

Warfarin-related nephropathy (WRN) is a renal complication of warfarin treatment associated with over-anticoagulation. We describe a case of a 73-year-old man affected by chronic kidney disease, essential hypertension and atrial fibrillation treated with warfarin. The patient presented a rapid course of kidney failure after many episodes of over-anticoagulation, and renal biopsy demonstrated WRN. Interestingly, the patient's warfarin pharmacogenetic profile showed that he was warfarin sensitive. This is the first report describing the presence of gene polymorphisms affecting warfarin metabolism in a subject with a biopsy-proven WRN. The patient was treated with corticosteroids obtaining a partial clinical response.

Keywords: acute kidney injury; chronic kidney disease; corticosteroids; warfarin pharmacogenetics; warfarin-related nephropathy

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