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Catacuzzeno L, Caramia M, Sforna L, et al. Reconciling the discrepancies on the involvement of large-conductance Ca(2+)-activated K channels in glioblastoma cell migration. Front Cell Neurosci. 2015;9:152doi: 10.3389/fncel.2015.00152.
Catacuzzeno, L., Caramia, M., Sforna, L., Belia, S., Guglielmi, L., D'Adamo, M. C., Pessia, M., & Franciolini, F. (2015). Reconciling the discrepancies on the involvement of large-conductance Ca(2+)-activated K channels in glioblastoma cell migration. Frontiers in cellular neuroscience, 9152. https://doi.org/10.3389/fncel.2015.00152
Catacuzzeno, Luigi, et al. "Reconciling the discrepancies on the involvement of large-conductance Ca(2+)-activated K channels in glioblastoma cell migration." Frontiers in cellular neuroscience vol. 9 (2015): 152. doi: https://doi.org/10.3389/fncel.2015.00152
Catacuzzeno L, Caramia M, Sforna L, Belia S, Guglielmi L, D'Adamo MC, Pessia M, Franciolini F. Reconciling the discrepancies on the involvement of large-conductance Ca(2+)-activated K channels in glioblastoma cell migration. Front Cell Neurosci. 2015 Apr 20;9:152. doi: 10.3389/fncel.2015.00152. eCollection 2015. PMID: 25941475; PMCID: PMC4403502.
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Front Cell Neurosci. 2015 Apr 20;9:152. doi: 10.3389/fncel.2015.00152. eCollection 2015.

Reconciling the discrepancies on the involvement of large-conductance Ca(2+)-activated K channels in glioblastoma cell migration.

Frontiers in cellular neuroscience

Luigi Catacuzzeno, Martino Caramia, Luigi Sforna, Silvia Belia, Luca Guglielmi, Maria Cristina D'Adamo, Mauro Pessia, Fabio Franciolini

Affiliations

  1. Dipartimento di Chimica, Biologia e Biotecnologie, Universita' di Perugia Perugia, Italy.
  2. Dipartimento di Medicina Sperimentale, Scuola di Medicina e Chirurgia, Universita' di Perugia Perugia, Italy.

PMID: 25941475 PMCID: PMC4403502 DOI: 10.3389/fncel.2015.00152

Abstract

Glioblastoma (GBM) is the most common and aggressive primary brain tumor, and is notable for spreading so effectively through the brain parenchyma to make complete surgical resection virtually impossible, and prospect of life dismal. Several ion channels have been involved in GBM migration and invasion, due to their critical role in supporting volume changes and Ca(2+) influx occuring during the process. The large-conductance, Ca(2+)-activated K (BK) channels, markedly overexpressed in biopsies of patients with GBMs and in GBM cell lines, have attracted much interest and have been suggested to play a central role in cell migration and invasion as candidate channels for providing the ion efflux and consequent water extrusion that allow cell shrinkage during migration. Available experimental data on the role of BK channel in migration and invasion are not consistent though. While BK channels block typically resulted in inhibition of cell migration or in no effect, their activation would either enhance or inhibit the process. This short review reexamines the relevant available data on the topic, and presents a unifying paradigm capable of reconciling present discrepancies. According to this paradigm, BK channels would not contribute to migration under conditions where the [Ca(2+)] i is too low for their activation. They will instead positively contribute to migration for intermediate [Ca(2+)] i , insufficient as such to activate BK channels, but capable of predisposing them to cyclic activation following oscillatory [Ca(2+)] i increases. Finally, steadily active BK channels because of prolonged high [Ca(2+)] i would inhibit migration as their steady activity would be unsuitable to match the cyclic cell volume changes needed for proper cell migration.

Keywords: BK channels; KCa1.1; glioblastoma multiforme (GBM); invasion; migration

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