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Litvinov IV, Netchiporouk E, Cordeiro B, et al. Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma. Oncoimmunology. 2014;3(11):e970025doi: 10.4161/21624011.2014.970025.
Litvinov, I. V., Netchiporouk, E., Cordeiro, B., Zargham, H., Pehr, K., Gilbert, M., Zhou, Y., Moreau, L., Woetmann, A., Ødum, N., Kupper, T. S., & Sasseville, D. (2014). Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma. Oncoimmunology, 3(11), e970025. https://doi.org/10.4161/21624011.2014.970025
Litvinov, Ivan V, et al. "Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma." Oncoimmunology vol. 3,11 (2014): e970025. doi: https://doi.org/10.4161/21624011.2014.970025
Litvinov IV, Netchiporouk E, Cordeiro B, Zargham H, Pehr K, Gilbert M, Zhou Y, Moreau L, Woetmann A, Ødum N, Kupper TS, Sasseville D. Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma. Oncoimmunology. 2014 Dec 21;3(11):e970025. doi: 10.4161/21624011.2014.970025. eCollection 2014 Nov. PMID: 25941598; PMCID: PMC4368148.
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Oncoimmunology. 2014 Dec 21;3(11):e970025. doi: 10.4161/21624011.2014.970025. eCollection 2014 Nov.

Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma.

Oncoimmunology

Ivan V Litvinov, Elena Netchiporouk, Brendan Cordeiro, Hanieh Zargham, Kevin Pehr, Martin Gilbert, Youwen Zhou, Linda Moreau, Anders Woetmann, Niels Ødum, Thomas S Kupper, Denis Sasseville

Affiliations

  1. Division of Dermatology; McGill University Health Centre ; Montréal, QC Canada.
  2. Division of Dermatology; Université Laval ; Québec City, QC Canada.
  3. Department of Dermatology and Skin Science; University of British Columbia ; Vancouver, BC Canada.
  4. Department of International Health, Immunology, and Microbiology; University of Copenhagen ; Copenhagen, Denmark.
  5. Department of Dermatology; Harvard Skin Disease Research Center; Brigham and Women's Hospital; Harvard University ; Boston, MA USA.

PMID: 25941598 PMCID: PMC4368148 DOI: 10.4161/21624011.2014.970025

Abstract

Cutaneous T-cell lymphoma (CTCL) is a potentially devastating malignancy. The pathogenesis of this cancer remains poorly elucidated. Previous studies focused on analysis of expression and function of known oncogenes and tumor suppressor genes. However, emerging reports highlight that it is also important to analyze the expression of genes that are ectopically expressed in CTCL (e.g., embryonic stem cell genes (ESC), cancer testis (CT) genes, etc.). Currently, it is not known whether ESC genes are expressed in CTCL. In the current work, we analyze by RT-PCR the expression of 26 ESC genes, many of which are known to regulate pluripotency and promote cancer stem cell-like phenotype, in a historic cohort of 60 patients from Boston and in a panel of 11 patient-derived CTCL cell lines and compare such expression to benign inflammatory dermatoses that often clinically mimic CTCL. Our findings document that many critical ESC genes including

Keywords: ALCL, Anaplastic Large Cell Lymphoma; BLK, B-lymphoid kinase; C-ALCL, Cutaneous Anaplastic Large Cell Lymphoma; CSC, Cancer Stem Cell; CTCL, Cutaneous T-Cell Lymphoma; DMC1, Disrupted Meiotic cDNA 1; ESC, Embryonic Stem Cell; EVA1, Epithelial C-like antigen 1; MF, Mycosis Fungoides; PBMC, Peripheral Blood Mononucleated Cells; PLS3, Plastin-3; PRC1, Polycomb Repressive Complex 1; PRC2, Polycomb Repressive Complex 2; SS, Sézary Syndrome; SYCP1, Synaptonemal Complex Protein 1; TOX, Thymocyte selection–associated high mobility group box; ZFX, Zinc finger protein X-linked; cancer testis genes; cutaneous T cell lymphoma (CTCL); embryonic stem cell genes; mycosis fungoides (MF); polycomb repressive complex 2 (PRC2); sézary syndrome (SS); thymocyte development genes

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